Results 51 to 60 of about 333,660 (389)

Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection.

Gastroenterology, 2019
BACKGROUND & AIMS NVR 3-778 is a first-in-class hepatitis B virus (HBV) capsid assembly modulator that can inhibit HBV replication. We performed a proof-of-concept study to examine the safety, pharmacokinetics, and antiviral activity of NVR 3-778 in ...
M. Yuen, E. Gane, D. J. Kim, F. Weilert, Henry Lik Yuen Chan, J. Lalezari, S. Hwang, Tuan T. Nguyen, O. Flores, G. Hartman, Sandy Liaw, O. Lenz, T. Kakuda, W. Talloen, C. Schwabe, K. Klumpp, N. Brown   +16 more
semanticscholar   +1 more source

Kinetics of acute hepatitis B virus infection in humans [PDF]

, 2001
Using patient data from a unique single source outbreak of hepatitis B virus (HBV) infection, we have characterized the kinetics of acute HBV infection by monitoring viral turnover in the serum during the late incubation and clinical phases of the ...
Brown, D., Dusheiko, G.M., Emery, V.C., Murray, J.M., Perelson, A.S., Webster, G.J.M., Whalley, S.A.   +6 more
core   +1 more source

Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load

Gut, 2019
Objective A hallmark of chronic HBV (cHBV) infection is the presence of impaired HBV-specific CD8+ T cell responses. Functional T cell exhaustion induced by persistent antigen stimulation is considered a major mechanism underlying this impairment ...
A. Schuch, E. Salimi Alizei, K. Heim, D. Wieland, M. Kiraithe, J. Kemming, S. Llewellyn-Lacey, Ö. Soğukpınar, Y. Ni, S. Urban, P. Zimmermann, M. Nassal, F. Emmerich, D. Price, B. Bengsch, Hendrik Luxenburger, C. Neumann-Haefelin, M. Hofmann, R. Thimme   +18 more
semanticscholar   +1 more source

New Perspectives on Treatment of Hepatitis B Before and After Liver Transplantation [PDF]

, 2016
open5noThe hepatitis B virus (HBV) infects more than 260 million people globally, with increasing incidence, especially in developing countries.
Bortoluzzi, Ilaria, Burra, Patrizia, Ferrarese, Alberto, Russo, Francesco Paolo, Zanetto, Alberto   +4 more
core   +1 more source

Epidemiology of Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) Related Hepatocellular Carcinoma

Open Virology Journal, 2018
Introduction: Hepatocellular carcinoma (HCC) is one of the most prevalent primary malignant tumors and accounts for about 90% of all primary liver cancers.
A. Petruzziello
semanticscholar   +1 more source

Persistence of immunity 18–19 years after vaccination against hepatitis B in 2 cohorts of vaccinees primed as infants or as adolescents in Italy

Human Vaccines & Immunotherapeutics, 2017
This study was aimed at assessing the anti-HBs persistence and immune memory 18–19 y after vaccination against hepatitis B in healthy individuals primed as infants or adolescents.
Luisa Romanò, Cristina Galli, Catia Tagliacarne, Maria Elena Tosti, Claudio Velati, Laura Fomiatti, Maria Chironna, Rosa Cristina Coppola, Mario Cuccia, Rossana Mangione, Fosca Marrone, Francesco Saverio Negrone, Antonino Parlato, Carla Maria Zotti, Alfonso Mele, Alessandro Remo Zanetti, the Study Group   +16 more
doaj   +1 more source

HBV genotypes circulation in pregnant women in Romania: a pilot study

Romanian Journal of Laboratory Medicine, 2020
Background: The risk of mother to child transmission of hepatitis B virus (HBV) is recognized worldwide, a reason for which the World Health Organization aims to reduce this public health issue of major concern in the next ten years. The aim of our study
Popovici Odette, Ursu Ramona Gabriela, Azoicai Doina, Iancu Luminita Smaranda   +3 more
doaj   +1 more source

HDV can constrain HBV genetic evolution in hbsag: Implications for the identification of innovative pharmacological targets [PDF]

, 2018
Chronic HBV + HDV infection is associated with greater risk of liver fibrosis, earlier hepatic decompensation, and liver cirrhosis hepatocellular carcinoma compared to HBV mono-infection.
Andreoni, Massimo, Angelico, Mario, Barlattani, Angelo, Battisti, Arianna, Bertoli, Ada, Cappiello, Giuseppina, Carioti, Luca, Ceccherini-Silberstein, Francesca, Colagrossi, Luna, Coppola, Nicola, De Cristofaro, Maria, DE SANCTIS, Giuseppe Maria, Fabeni, Lavinia, Fleury, Hervé, Iapadre, Nerio, Lanza, Alfonso Galeota, Lenci, Ilaria, Lichtner, Miriam, Malagnino, Vincenzo, Mari, Terenzio, Marignani, Massimo, Mastroianni, Claudio, Minichini, Carmine, Nebuloso, Elena, Pasquazzi, Caterina, Perno, Carlo-Federico, Piermatteo, Lorenzo, Salpini, Romina, Sarmati, Loredana, Scutari, Rossana, Spanò, Alberto, Stanzione, Maria, Stornaiuolo, Gianfranca, Svicher, Valentina, Trimoulet, Pascale   +34 more
core   +2 more sources

HBV DNA Integration: Molecular Mechanisms and Clinical Implications

Viruses, 2017
Chronic infection with the Hepatitis B Virus (HBV) is a major cause of liver-related morbidity and mortality. One peculiar observation in cells infected with HBV (or with closely‑related animal hepadnaviruses) is the presence of viral DNA integration in ...
T. Tu, M. Budzinska, N. Shackel, S. Urban   +3 more
semanticscholar   +1 more source

Seroprevalence and Associated Factors of Hepatitis B and Hepatitis C Viral Infections Among Prisoners in Tigrai, Northern Ethiopia

Infection and Drug Resistance, 2023
Belaynesh Tsegay,1 Teklay Gebrecherkos,2 Atsebaha Gebrekidan Kahsay,2 Mahmud Abdulkader2 1Ayder Comprehensive Specialized Hospital Laboratory Department, Mekelle University, Mekelle, Tigrai, Northern Ethiopia; 2Department of Medical Microbiology and ...
Tsegay B, Gebrecherkos T, Kahsay AG, Abdulkader M   +3 more
doaj