Results 81 to 90 of about 2,204,237 (310)

Standardized Hepatitis B Virus RNA Quantification in Untreated and Treated Chronic Patients: a Promising Marker of Infection Follow-Up

Microbiology Spectrum, 2022
The measurement and interpretation of HBV DNA and RNA levels in HBV infected patients treated with antiviral therapy supports the objective of HBV disease management.
Maria Francesca Cortese, Mar Riveiro-Barciela, David Tabernero, Francisco Rodriguez-Algarra, Adriana Palom, Sara Sopena, Ariadna Rando-Segura, Luisa Roade, Alison Kuchta, Roser Ferrer-Costa, Josep Quer, Beatriz Pacin, Marta Vila, Rosario Casillas, Selene Garcia-Garcia, Rafael Esteban, Tomás Pumarola, Maria Buti, Francisco Rodriguez-Frias   +18 more
doaj   +1 more source

Correlation between hepatitis B G1896A precore mutations and HBeAg in chronic HBV patients [PDF]

, 2015
Background: Hepatitis B virus (HBV) infection is an important health concern worldwide, with critical outcomes. Hepatitis B e antigen (HBeAg) negative chronic hepatitis B is frequently caused by a mutation (G1896A) in the hepatitis B virus (HBV) precore (
Adli, A.H., Karami, C., Khodabakhshi, B., Moradi, A., Tabarraei, A., Zhand, S.   +5 more
core   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with Hepatitis B virus infection [PDF]

, 2005
CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell responses of patients with chronic and resolved ...
Bertoletti, A., Franzese, O., Gehring, A.J., Gotto, J., Kennedy, P.T.F., Maini, M.K., Williams, R.   +6 more
core   +2 more sources

A Deep Representation Learning Method for Quantitative Immune Defense Function Evaluation and Its Clinical Applications

Advanced Science, EarlyView.
ImmuDef, a novel algorithm to quantitatively evaluate the anti‐infection immune defense function of an individual based on RNA‐seq data via a variational autoencoder (VAE) model. It is validated on 3200+ samples across four immune states with high accuracy. It can serve as a metric for disease severity and prognosis across pathogenic cohorts.
Zhen‐Lin Tan, Tao Luo, Yu Lin, Xiao‐Jun Wu, Wen‐Kang Shen, Jie Chen, Qian Lei, An‐Yuan Guo   +7 more
wiley   +1 more source

Xenosurveillance reflects traditional sampling techniques for the identification of human pathogens: A comparative study in West Africa [PDF]

, 2018
BACKGROUND: Novel surveillance strategies are needed to detect the rapid and continuous emergence of infectious disease agents. Ideally, new sampling strategies should be simple to implement, technologically uncomplicated, and applicable to areas where ...
Bolay, Fatorma K, Bolay, Kpehe, Brackney, Doug E, Diclaro, Joseph W, II, Ebel, Gregory D, Fakoli, Lawrence S, III, Fauver, Joseph R, Foy, Brian D, Stenglein, Mark D, Weger-Lucarelli, James   +9 more
core   +6 more sources

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

The relationship between serum hepatitis B virus DNA level and liver histology in patients with chronic HBV infection. [PDF]

PLoS ONE, 2018
BACKGROUND:There is no consensus regarding the relationship between HBV DNA and liver fibrosis, and the relationship between HBV DNA and the degree of liver cirrhosis has not been reported in patients with chronic HBV infection. METHODS:From January 2011
Changjiang Liu, Li Wang, Huizhong Xie, Liyuan Zhang, Bingshu Wang, Chun Luo, Suiqun Wang, Mingliang Tang, Zhongbiao Fu, Hailan Ruan, Zhengjin Liu, Ling Wei, Wenyi Yi, Yunqian Xie   +13 more
doaj   +1 more source

Study on the hepatitis B virus infection in blood donors reactive to jointed NAT but non-reactive to primary discriminatory test

Zhongguo shuxue zazhi, 2022
Objective To analyze the status of HBV infection in blood donors reactive to jointed NAT but non-reactive to primary discriminatory tests (NRR), so as to provide suggestions and data support for subsequent studies on NRR samples.
Fengyuan LI, Tong PAN, Xia WANG, Fuhua ZHANG, Huafei GONG   +4 more
doaj   +1 more source

Clinical, epidemiological and virological features of acute hepatitis B in Italy [PDF]

, 2015
Purpose To evaluate the association of hepatitis B virus (HBV) genotypes, basal core promoter (BCP)/precore (PC) and S gene mutations with the clinical-epidemiological characteristics of acute hepatitis B (AHB) in Italy.
Alessandro Remo Zanetti, Alfonso Mele, Andrea Mariano, Claudio Galli, Enea Spada, Gloria Taliani, Luisa Romanò, Maria Elena Tosti, Massimo Clementi, null null, Ornella Zuccaro   +10 more
core   +1 more source