Results 61 to 70 of about 69,966 (266)

A descriptive case series of hepatotoxicity associated with CFTR modulators and possible relevance of pharmacogenetic polymorphisms in cystic fibrosis patients

British Journal of Clinical Pharmacology, EarlyView.
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators are widely used in patients with cystic fibrosis and significantly improve respiratory function and quality of life. However, their effectiveness may be limited by liver damage, which sometimes leads to treatment discontinuation, and the mechanisms underlying this remain poorly ...
Clara Laffitte Redondo, Venceslas Bourdin, Abd El Kader Ait Tayeb, Sihem Benaboud, Inès Martins, Caroline Joyau, Myriam Benhamida, Isabelle Sermet‐Gaudelus, Clémence Martin, Pierre Régis Burgel, Céline Verstuyft, Laurent Chouchana, Estelle Ayme‐Dietrich   +12 more
wiley   +1 more source

Population Genomics Insights into Pharmacogenomic Differentiation Between East Asians and Europeans

Clinical Pharmacology &Therapeutics, EarlyView.
Genetic variation contributes substantially to interindividual and interpopulation differences in drug response, yet most pharmacogenomic studies remain biased toward European populations. Here, we systematically assessed pharmacogenomic variation across East Asians (EAS) and Europeans (EUR) using public genomic datasets and investigated the potential ...
Sihan Chen, Hongpu Chen, Shuhua Xu
wiley   +1 more source

EVALUATION OF HBV DNA LEVELS IN SALIVA IN SUBJECTS WITH DIFFERENT VIREMIA AS WELL AS DURING PEGINTERFERON α-2a THERAPY. [PDF]

Journal of IMAB, 2013
Hepatitis B virus is the most important infectious hazard in dental profession. Vectors of HBV infection are not only blood, but also saliva, nasopharyngeal secretions, crevicular fluid.The aim of the study was to evaluate serum and salivary HBV DNA ...
Assya Krasteva, Vladimir E. Panov, Dejan Jelev, Krasimir Antonov, Aneta Ivanova, Zahariy Krastev   +5 more
doaj   +1 more source

Development of Pentaplex Reverse Transcription Droplet Digital PCR Assay for Simultaneous Detection and Absolute Quantification of HIV‐1, HIV‐2, HCV, and HBV With Internal Control

ELECTROPHORESIS, EarlyView.
Development of Pentaplex reverse transcription droplet digital PCR assay for simultaneous detection and absolute quantification of HIV‐1, HIV‐2, HCV, and HBV with internal control. The channel‐resolved multiplex strategy enables high sensitivity, robust quantification, and scalable digital PCR workflows across platforms.
Soo Yeon Lim, Un Na Koh, Ah Leum Kim, Yebin Kim, Ga Eun Kim, Si‐Keun Lim   +5 more
wiley   +1 more source

The relationship between serum hepatitis B virus DNA level and liver histology in patients with chronic HBV infection. [PDF]

PLoS ONE, 2018
BACKGROUND:There is no consensus regarding the relationship between HBV DNA and liver fibrosis, and the relationship between HBV DNA and the degree of liver cirrhosis has not been reported in patients with chronic HBV infection. METHODS:From January 2011
Changjiang Liu, Li Wang, Huizhong Xie, Liyuan Zhang, Bingshu Wang, Chun Luo, Suiqun Wang, Mingliang Tang, Zhongbiao Fu, Hailan Ruan, Zhengjin Liu, Ling Wei, Wenyi Yi, Yunqian Xie   +13 more
doaj   +1 more source

In situ analysis of hepatitis B virus (HBV) antigen and DNA in HBV-induced hepatocellular carcinoma [PDF]

, 2022
Aims: Hepatitis B Virus (HBV) infection is the major risk factor for hepatocellular carcinoma (HCC) in East Asia. Here we aimed to further investigate the abundance of viral antigen and DNA within HBV-related HCC and surrounding tissues at histological ...
Zeng, Dong, Tong, Haitao, Zheng, Ye, Xu, Mingzhu, Shi, Yuhan, Feng, Yanling, Zhang, Xiaonan; id_orcid   +6 more
core   +1 more source

Natural history of decompensated cirrhosis with serum hepatitis B DNA < 2000 IU/mL: a retrospective study

BMC Gastroenterology, 2022
Background and aims Patients with low HBV DNA levels (
Xu Huang, Meimei Yan, Zerun Deng, Lei Yao, Dan Han, Lihua Sun   +5 more
doaj   +1 more source

The risky body mass index ranges for significant hepatitis B viral load: A campus-based study

, 2014
Significant hepatitis B viral load (>= 10,000 copies/mL) was established to increase risk of advanced liver diseases. The aim of this study was to explore the metabolic risk factors for significant hepatitis B viral load.
Chiang, Chien-Hsieh;Lai, Jin-Shin;Sheu, Jin-Chuan;Yen, Lee-Lan;Liu, Chun-Jen;Huang, Kuo-Chin, 賴金鑫 ;江建勰 ;劉俊人 ;李蘭 ;黃國晉 ;許金川   +1 more
core   +1 more source

Occult Hepatitis B Virus Infection in Chacma Baboons, South Africa

Emerging Infectious Diseases, 2013
During previous studies of susceptibility to hepatitis B virus (HBV) infection, HBV DNA was detected in 2/6 wild-caught baboons. In the present study, HBV DNA was amplified from 15/69 wild-caught baboons. All animals were negative for HBV surface antigen
Caroline Dickens, Michael C. Kew, Robert H. Purcell, Anna Kramvis   +3 more
doaj   +1 more source

Soroprevalência de marcadores da infecção pelo HBV e dos títulos de anti-HBs em indivíduos soropositivos para o HIV [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências de Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2014.As infecções pelo HIV e pelo HBV são preocupantes problemas de saúde pública, sendo que, a infecção ...
Martins, Saulo
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