Results 201 to 210 of about 236,151 (302)

Identification and credentialing of patient-derived xenograft models of invasive lobular carcinoma

Disease Models & Mechanisms
Jagmohan Hooda, Jennifer M. Atkinson, Osama Shiraz Shah, Megan Yates, Daniel D. Brown, Morgan DeBerry, Stefano Cairo, Paolo Schiavini, Hsiu-Wen Tsai, Marianna Zipeto, Rohit Bhargava, Steffi Oesterreich, Adrian V. Lee   +12 more
doaj   +1 more source

Gut Microbiota in Hepatocellular Carcinoma: Etiology-Specific Evidence, Mechanisms, and Translational Challenges. [PDF]

J Hepatocell Carcinoma
Guan X.
europepmc   +1 more source

Unraveling the Multimodal Oncogenic Network of KITENIN: From Metabolic Reprogramming and Microenvironment Remodeling to Targeted Interventions

Cancer Nexus, EarlyView.
ABSTRACT KAI1 C‐terminal interacting tetraspanin (KITENIN) is an emerging oncogenic regulator associated with tumorigenesis, metastasis, therapeutic resistance, and poor clinical outcomes. Mechanistically, KITENIN promotes tumor cell proliferation, migration, invasion, and epithelial–mesenchymal transition (EMT) by activating oncogenic pathways ...
Niaz Mahmood Tanoy, Zarin Tasnim, Md Shiblee Sadik Sabuj, Tanvir Ahmed, Md Abdul Momin, Md Sadekuzzaman, Sumaia Islam Mow, Md Aktaruzzaman, Md Rashedunnabi Akanda   +8 more
wiley   +1 more source

Model‐based clinical pharmacology profiling of subcutaneous nivolumab in renal cell carcinoma: Bridging to alternative dosing regimens and indications

Clinical Pharmacology &Therapeutics, EarlyView.
A novel model‐informed drug development (MIDD) approach was employed to derive the coprimary endpoints (time‐averaged serum concentration over 28 days [Cavgd28] and minimum serum concentration at steady state [Cminss]) of the phase III CheckMate 67T study (NCT04810078).
Yue Zhao, Zheyi Hu, Elizabeth Gibson, Li Zhu, Heather Vezina, Anna G. Kondic   +5 more
wiley   +1 more source

Structural Effects of Vertical Non‐Skeletal Elements (NSEs) With Rocking Mechanisms

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT This paper introduces the structural effects provided by vertical non‐skeletal elements (NSEs), such as claddings and partitions, with vertical slotted holes at their supports to enable rocking as the frame undergoes significant lateral deformation.
Zheng Luo, Gregory A. MacRae, Chin‐Long Lee   +2 more
wiley   +1 more source

A Numerical Investigation of the Effects of Piston Bowl Geometry and Spray Angle on Combustion, Performance and Emission of a Diesel Engine

Energy Science &Engineering, EarlyView.
A piston bowl's design and spray angle improve air‐fuel mixing, resulting in more complete combustion and higher efficiency. Ansys Forte 2023 R1 a CFD software was used to analyze the effects of five combustion chamber geometries of cylinder, modified re‐entrant, re‐entrant, double‐stepped, and stepped on engine performance, combustion, and emission ...
Md. Nazmul Haque, Abdullah Al Rifat, Tafsirul Hassan, Md. Ifthaker Alam, Mohammad Mehedi Hasan Kazol, Md. Ashraful Islam, Abidur Rahman Adib, Mizanur Rahman   +7 more
wiley   +1 more source

Gut Microbiome and Hepatic Transcriptomic Determinants of HCC Development in Mice with Metabolic Dysfunction-Associated Steatohepatitis [PDF]

Lillian I Dolapchiev,1,* Kristyn A Gonzales,1,* Lorenzo R Cruz Graham,1 Mihai Gagea,2 Heather L Stevenson,3 Suet-Ying Kwan,1 Laura Beretta1 1Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston,
Kwan SY, Gonzales KA, Cruz Graham LR, Stevenson HL, Beretta L, Dolapchiev LI, Gagea M   +6 more
core  

ER‐Localized Deadenylase PNLDC1 Suppresses Colorectal Cancer Progression by Targeting the mRNA Decay of TUBB4B

Exploration, EarlyView.
The deficiency of PNLDC1 exacerbates the advancement of CRC. PNLDC1 interacts with TUBB4B mRNA to regulate the p53–p21–CDK2–cyclin E2 pathway, thereby influencing the G2/M phase of the cell cycle. ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer‐related mortality, highlighting the urgent need for novel therapeutic strategies.
Lexin Liu, Yuelin Guan, Yuzhou Qin, Guiping Chen, Guozhen Wang, Xiang Yan, Xue Li, Lei Sun, Wei Yu, Shi Ouyang, Zhichao Ma, Zihao Xu, Zhongkai Cao, Fan Yu, Tong Zhou, Ziyou Luo, Xiangjun Chen, Yongbin Yan, Lidan Hu   +18 more
wiley   +1 more source

Correspondence to letter to the editor 1 on “Conventional and machine learning-based risk scores for patients with early-stage hepatocellular carcinoma” [PDF]

Clinical and Molecular Hepatology
Chun-Ting Ho, Elise Chia-Hui Tan, Chien-Wei Su   +2 more
doaj   +1 more source

A PD‐L1 Nanobody‐Engineered Synthetic RNA Virus Enhances Hepatocellular Carcinoma Immunotherapy by Interfering PCSK9 and Upregulating MHC‐I

Exploration, EarlyView.
A PD‐L1 nanobody‐engineered synthetic RNA virus (αPDL1‐VLPs/shPCSK9) is fabricated to inhibit PCSK9 and upregulate MHC‐I to facilitate T cells recognition of hepatocellular carcinoma (HCC). Moreover, αPDL1‐VLPs/shPCSK9 can recognize PD‐L1 and block the PD‐1/PD‐L1 pathway to prevent immune evasion, while promoting M2‐to‐M1 macrophages polarization ...
Chuyu Huang, Yun Ye, Yi Guo, Guozheng Liao, Linyi Luo, Lingwen Ding, Yingling Miao, Linping Zhao, Yongchang Ouyang, Shiying Li   +9 more
wiley   +1 more source