Results 141 to 150 of about 78,362 (247)

Evaluation of red blood cell distribution width in cats with hypertrophic cardiomyopathy [PDF]

, 2015
Connolly, D J, Cowlam, R, English, K, Stanzani, G   +3 more
core   +1 more source

Transcriptional and functional effects of mavacamten in multiple porcine and human models with hypertrophic cardiomyopathy

British Journal of Pharmacology, Volume 183, Issue 5, Page 1122-1139, March 2026.
Abstract Background and Purpose Mavacamten (MAVA) is a novel small molecule inhibitor of cardiac myosin, mitigating cardiomyocyte hypercontractility in patients with hypertrophic obstructive cardiomyopathy (HOCM). Despite its recent approval for clinical use, the transcriptional and functional impacts of MAVA remain not well understood.
Elisa Kiselev, Wilson Agyapong, Bjarne Jürgens, Elisa Mohr, Shambhabi Chatterjee, Hannah J. Hunkler, Jawad Salman, Giuseppe Cipriano, Marco Bentele, Junqing Liu, Jonas Specht, Kaja S. Menge, Florian J. G. Waleczek, Jonas A. Haas, Anselm A. Derda, Kristina Sonnenschein, Anika Gietz, Susanne Neumüller, Angelika Pfanne, Oliver Beetz, Michael Pflaum, Bettina Wiegmann, Yiangos Psaras, Christopher Toepfer, Robert Zweigerdt, Ante Radocaj, Theresia Kraft, Andre Zeug, Evgeni Ponimaskin, Wilhelm Korte, Alexander Horke, Arjang Ruhparwar, Maximilian Fuchs, Ke Xiao, Christian Bär, Natalie Weber, Thomas Thum   +36 more
wiley   +1 more source

Epidemiology of Hypertrophic Cardiomyopathy in the United States From 2016 to 2023. [PDF]

JACC Adv
Butzner M, ElHabr AK, Farajkhah K, Chhatwal J, Ayer T, Gebrehiwet P, Shreay S, Riello RJ, Desai NR, Owens AT, Abraham T, Masri A.   +11 more
europepmc   +1 more source

Work productivity, associated risk factors and costs on presenteeism and absenteeism in Chinese patients with young‐onset type‐2 diabetes in Hong Kong

Diabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 1730-1740, March 2026.
Abstract Aims Those with young‐onset type‐2 diabetes (YOD), diagnosed before age of 40 years, experience heightened risk of complications. The economic burden extends beyond medical costs, impacting work productivity. Materials and Methods Chinese patients with YOD were recruited between June 2023 and April 2024 in the Precision Medicine to redefine ...
Juliana N. M. Lui, Kelly T. C. Wong, Eric S. H. Lau, Sunny C. S. Chan, Nga Sze Wong, Jenny Y. Z. Zhang, Kit Ming Wai, Chun Kwan O, Baoqi Fan, Hongjiang Wu, Ronald C. W. Ma, Alice P. S. Kong, Andrea O. Y. Luk, Elaine Y. K. Chow, Juliana C. N. Chan   +14 more
wiley   +1 more source

Strain‐Release Diversification of 1‐Azabicyclobutanes via Bromide/Nickel Relay Catalyzed 1,3‐Bis‐Carbofunctionalization

Angewandte Chemie International Edition, Volume 65, Issue 7, 9 February 2026.
A four‐component synthesis of azetidines with an all‐carbon quaternary center via strain‐release 1,3‐bis‐carbofunctionalization of 1‐azabicyclobutanes (ABB) is described. Each reaction component can be modified to permit a high‐throughput‐like library preparation, producing azetidines with various appendages, including biorelevant molecules.
Yi‐Hua Lee, Che‐Ming Hsu, Shinje Miñoza, Ya‐Fang Shih, Yu‐Chun Ding, Tzu‐Yao Hsu, Song‐Ting Chen, Kuei‐Chen Chang, Wen‐Hsuan Lee, Yuya A. Lin, Hsuan‐Hung Liao   +10 more
wiley   +1 more source

Self- and Goal-Directed Valsalva Maneuver vs Exercise in Eliciting Left Ventricular Outflow Tract Obstruction. [PDF]

JACC Adv
Bavishi A, Fritzlen J, Nazif K, Soutar M, Kurnides M, Speer H, Oyarce G, Richards K, Flahive C, Martinez MW.   +9 more
europepmc   +1 more source

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, Volume 13, Issue 7, 3 February 2026.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

Surgical management of hypertrophic cardiomyopathy. [PDF]

Indian J Thorac Cardiovasc Surg
Ananthanarayanan C, Modugula SR, Chauvette V, Ragheb D, Bhagat R, Smedira N.   +5 more
europepmc   +1 more source

Variation in the Angle of the First Pedal Ray Relative to the Midline of the Foot by Sex and Parity History

American Journal of Biological Anthropology, Volume 189, Issue 2, February 2026.
ABSTRACT Objective Although pathological variations of the first pedal ray have been well‐studied, non‐pathologic variations, including those potentially linked to hormonal changes during pregnancy, have yet to be examined. Here we quantify the angle between the longitudinal axes of the first and third metatarsals and investigate variation in this ...
Paige S. Whitman, Addie E. C. Lomax, Patricia Ann Kramer, Christine M. Harper   +3 more
wiley   +1 more source

Whole‐bone shape of hominoid manual proximal phalanges

The Anatomical Record, Volume 309, Issue 2, Page 245-270, February 2026.
Abstract Functional morphologists have long noted that skeletal adaptations in primate phalanges reflect locomotor behavior. While most studies have successfully used two‐dimensional measurements to quantify general features of phalanx shape, a whole‐bone three‐dimensional analysis may better capture more subtle aspects of phalanx morphology that have ...
Deanna M. Goldstein, Christine M. Harper, Megan Solís, Caley M. Orr, Sergio Almécija, Matthew W. Tocheri, Tea Jashashvili, Biren A. Patel   +7 more
wiley   +1 more source