Results 141 to 150 of about 21,803 (222)

Unusual flow patterns in a left ventricular aneurysm in hypertrophic cardiomyopathy: a case report. [PDF]

Eur Heart J Case Rep
Salahuddin S, Karunakaran B.
europepmc   +1 more source

Transcriptional and functional effects of mavacamten in multiple porcine and human models with hypertrophic cardiomyopathy

British Journal of Pharmacology, Volume 183, Issue 5, Page 1122-1139, March 2026.
Abstract Background and Purpose Mavacamten (MAVA) is a novel small molecule inhibitor of cardiac myosin, mitigating cardiomyocyte hypercontractility in patients with hypertrophic obstructive cardiomyopathy (HOCM). Despite its recent approval for clinical use, the transcriptional and functional impacts of MAVA remain not well understood.
Elisa Kiselev, Wilson Agyapong, Bjarne Jürgens, Elisa Mohr, Shambhabi Chatterjee, Hannah J. Hunkler, Jawad Salman, Giuseppe Cipriano, Marco Bentele, Junqing Liu, Jonas Specht, Kaja S. Menge, Florian J. G. Waleczek, Jonas A. Haas, Anselm A. Derda, Kristina Sonnenschein, Anika Gietz, Susanne Neumüller, Angelika Pfanne, Oliver Beetz, Michael Pflaum, Bettina Wiegmann, Yiangos Psaras, Christopher Toepfer, Robert Zweigerdt, Ante Radocaj, Theresia Kraft, Andre Zeug, Evgeni Ponimaskin, Wilhelm Korte, Alexander Horke, Arjang Ruhparwar, Maximilian Fuchs, Ke Xiao, Christian Bär, Natalie Weber, Thomas Thum   +36 more
wiley   +1 more source

Epidemiology of Hypertrophic Cardiomyopathy in the United States From 2016 to 2023. [PDF]

JACC Adv
Butzner M, ElHabr AK, Farajkhah K, Chhatwal J, Ayer T, Gebrehiwet P, Shreay S, Riello RJ, Desai NR, Owens AT, Abraham T, Masri A.   +11 more
europepmc   +1 more source

Mind the Gap! Sleep Problems in Children With ADHD—A Qualitative Analysis of Clinician Training Needs

Child: Care, Health and Development, Volume 52, Issue 2, March 2026.
ABSTRACT Background This study aims to explore for the first time the knowledge, understanding and management of sleep problems in children with ADHD among clinicians who specialise in sleep and ADHD. The aim was to inform the development of digital sleep awareness training for clinicians.
Lucy Smith, David Daley, Samuele Cortese, Catherine M. Hill, on behalf of the DISCA team   +4 more
wiley   +1 more source

Targeting the Sarcomere: Myosin Inhibitors as the Revolutionary Game Changer in Hypertrophic Cardiomyopathy. [PDF]

Rev Cardiovasc Med
Sedaghat-Hamedani F, Kayvanpour E, Meder B.   +2 more
europepmc   +1 more source

Clinical Evaluation of Drug–Drug Interactions With Aficamten

Clinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT Aficamten is a next‐in‐class small molecule cardiac myosin inhibitor that was recently approved by the United States Food and Drug Administration (FDA) for the treatment of symptomatic obstructive hypertrophic cardiomyopathy (oHCM). A comprehensive drug–drug interaction (DDI) evaluation of aficamten was achieved through two phase 1 studies in ...
Neha Maharao, Donghong Xu, Punag Divanji, Tyrell J. Simkins, Jianlin Li, Camelia Dumitrescu, Priyanka Solanki, Adrienne Griffith, Stephen B. Heitner, Stuart Kupfer, Polina German, Justin D. Lutz   +11 more
wiley   +1 more source

Characterising the phenotype and ‍outcomes of cascade-tested relatives of probands with ‍hypertrophic cardiomyopathy. [PDF]

Open Heart
Chaudhry WR, McWilliam C, Berg J, Choy AM.   +3 more
europepmc   +1 more source

Editorial Comments on PTHrP‐Producing Renal Cell Carcinoma Presenting as Rapidly Progressive Cognitive Impairment: A Case Report

IJU Case Reports, Volume 9, Issue 2, March 2026.
Kento Morozumi
wiley   +1 more source

Work productivity, associated risk factors and costs on presenteeism and absenteeism in Chinese patients with young‐onset type‐2 diabetes in Hong Kong

Diabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 1730-1740, March 2026.
Abstract Aims Those with young‐onset type‐2 diabetes (YOD), diagnosed before age of 40 years, experience heightened risk of complications. The economic burden extends beyond medical costs, impacting work productivity. Materials and Methods Chinese patients with YOD were recruited between June 2023 and April 2024 in the Precision Medicine to redefine ...
Juliana N. M. Lui, Kelly T. C. Wong, Eric S. H. Lau, Sunny C. S. Chan, Nga Sze Wong, Jenny Y. Z. Zhang, Kit Ming Wai, Chun Kwan O, Baoqi Fan, Hongjiang Wu, Ronald C. W. Ma, Alice P. S. Kong, Andrea O. Y. Luk, Elaine Y. K. Chow, Juliana C. N. Chan   +14 more
wiley   +1 more source

Hypertrophic cardiomyopathy: comprehensive insights into pathogenic genes and genotype-phenotype associations. [PDF]

Front Cell Dev Biol
Hao L, Chen X, Qin B.
europepmc   +1 more source