Results 91 to 100 of about 46,134 (291)
Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation [PDF]
, 2014 NKG2D plays a major role in controlling immune responses through the regulation of natural killer (NK) cells, αβ and γδ T-cell function. This activating receptor recognizes eight distinct ligands (the MHC Class I polypeptide-related sequences (MIC) A ...
A Dolan +98 more
core +17 more sources
Differential regulation of translational stress responses by herpesvirus ubiquitin deconjugases
The FEBS Journal, EarlyView.Translating viral mRNAs is challenging due to structural features that may slow translation or induce ribosome stalling. The viral ubiquitin deconjugases encoded by human pathogenic herpesviruses regulate the cellular response to ribosomal stress by inhibiting various branches of the Ribosomal Quality Control (RQC) and activating Ribosomal Stress ...
Jiangnan Liu +3 more
wiley +1 more source
Human Cytomegalovirus (HCMV)-infected Astrocytoma Cells Impair the Function of HCMV-specific Cytotoxic T Cells [PDF]
Journal of Korean Medical Science, 2020 Human cytomegalovirus (HCMV) infection in glioblastoma multiforme (GBM) is associated with a poor prognosis and may affect the pathogenesis of GBM. In this study, we investigated the role of HCMV-infected astrocytoma cells in impairing the activity of cytotoxic T lymphocytes (CTLs) specific to the HCMV protein.CTLs specific to HCMV immediate early (IE)-
Jiyeon Kim, Won-Woo Lee, Eung Soo Hwang
openaire +2 more sources
HCMV-Encoded NK Modulators: Lessons From in vitro and in vivo Genetic Variation
Frontiers in Immunology, 2018 Human cytomegalovirus (HCMV) is under constant selective pressure from the immune system in vivo. Study of HCMV genes that have been lost in the absence of, or genetically altered by, such selection can focus research toward findings of in vivo ...
Mihil Patel +5 more
semanticscholar +1 more source
Journal of Internal Medicine, EarlyView.Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Annelise E. Barron +3 more
wiley +1 more source
Infectious Agents and Cancer, 2020 Background The cause of epithelial ovarian cancer (EOC) is not elucidated. Viral infection may induce chronic inflammatory infection and play a role in the pathogenesis of cancers.
Min Yin +5 more
doaj +1 more source
A novel ultrasensitive electrochemical genosensor based on PtNPs/EEGO-AGs/AuNPs nanoassembly for rapid detection of HCMV miRNA. [PDF]
BMC ChemNahid-Samiei R +8 more
europepmc +2 more sources
Single-cell profiling identifies impaired adaptive NK cells expanded after HCMV reactivation in haploidentical HSCT [PDF]
, 2021 Elisa Zaghi +21 more
openalex +1 more source
Scientific Reports, 2018 Increasing evidence indicates that human cytomegalovirus (HCMV) populations under the influence of host environment, can either be stable or rapidly differentiating, leading to tissue compartment colonization.
Fatima Moussawi +6 more
semanticscholar +1 more source
Journal of Periodontal Research, EarlyView.HSV‐1 infects oral mesenchymal stem cells both in vitro and in vivo to dysregulate their lineage commitment. An inflamed gingival environment increases susceptibility to HSV‐1 infection, which further elevates proinflammatory cytokine levels and exacerbates alveolar bone loss.
Araceli Valverde +9 more
wiley +1 more source