Results 91 to 100 of about 28,017 (205)

Monoubiquitination of syntaxin 3 leads to retrieval from the basolateral plasma membrane and facilitates cargo recruitment to exosomes [PDF]

, 2017
Syntaxin 3 (Stx3), a SNARE protein located and functioning at the apical plasma membrane of epithelial cells, is required for epithelial polarity.
Adrian J. Giovannone, Alberto Fraile-Ramos, Alenquer M, Barbieri MA, Bezprozvanny I, Bilodeau PS, Breuza L, Britt WJ, Calistri A, Campeau E, Castle AM, Cepeda V, Cepeda V, Chin LS, Clague MJ, Danielsen JM, Delgrossi MH, Dragovic RA, Elena Reales, Fowler KB, Fraile-Ramos A, Fraile-Ramos A, Fujita H, Geng L, Gong Q, Gonzales PA, Guo X, Guo Z, Hackam DJ, Henne WM, Hibi T, Hicke L, Hislop JN, Hong W, Huang F, Huang S, Hurley JH, Jahn R, Kamsteeg EJ, Keith E. Mostov, Kim W, Kwon SH, Kyuuma M, Lakkaraju A, Leung YM, Li X, Liu ST, Low SH, Marchese A, McCullough J, McSharry BP, Meckes DG, Moffat J, Mori Y, Na CH, Naldini L, Naren AP, Olkkonen VM, Ostrowski M, Pallavi Bhattaram, Pawliczek T, Raiborg C, Raiborg C, Ren J, Riento K, Rodriguez-Boulan E, Rothman JE, Sharma N, Shields SB, Shih SC, Simons M, Singer-Lahat D, Somsel Rodman J, Stringer DK, Sudhof TC, Tandon R, ter Beest MB, Thery C, Thomas Weimbs, van Niel G, Weimbs T, Weimbs T, Weimbs T, Wickner W, Wojcikiewicz RJ, Yatsu A, Zerial M   +86 more
core   +3 more sources

Inflammatory and vascular biomarkers as predictors of all‐cause death and cardiovascular outcomes in an Australian community‐based cohort

Physiological Reports, Volume 13, Issue 11, June 2025.
Abstract Biomarkers that identify individuals who are at higher risk of cardiovascular outcomes will allow for early intervention, lowering the incidence of adverse outcomes. This study investigated whether circulating levels of GDF‐15, E‐selectin, CD14, and ST2 are predictors of death and cardiovascular outcomes in 981 individuals who did not have a ...
Silvia Lee, Alison Castley, Matthew Knuiman, David Nolan, Frank Sanfilippo, Girish Dwivedi   +5 more
wiley   +1 more source

Distinct expression profile of HCMV encoded miRNAs in plasma from oral lichen planus patients

Journal of Translational Medicine, 2017
BackgroundOral lichen planus (OLP) is a T cell-mediated autoimmune disease. The aetiology and molecular mechanisms of OLP remain unclear. Human cytomegalovirus (HCMV) infection is a causal factor in the development of various diseases, but the clinical ...
Meng Ding, Xiang Wang, Cheng Wang, Xiaoshuang Liu, Ke Zen, Wenmei Wang, Chen-Yu Zhang, Chunni Zhang   +7 more
semanticscholar   +1 more source

Identification of the Micro‐Ribonucleic Acid Profiles of Plant‐Derived Extracellular Vesicles and their Potential Crosskingdom Regulation

Advanced NanoBiomed Research, Volume 5, Issue 5, May 2025.
The present study employs small RNA sequencing to identify the types and content of microRNAs (miRNAs) in four widely utilized plant‐derived extracellular vesicles (pEVs). The functional annotation reveals that the pEV miRNAs are involved in regulating the progression of human cancer and viral infection, thereby demonstrating the crosskingdom ...
Fei Wang, Junyao Deng, Shushan Mo, Jiacong Ai, Yingxian Xiao, Xiaohan Zhou, Zhenhua Li, Lanya Li   +7 more
wiley   +1 more source

Short communication: NKG2C+ NK cells contribute to increases in CD16+CD56- cells in HIV type 1+ individuals with high plasma viral load. [PDF]

, 2012
Chronic HIV-1 infection results in the expansion of both NKG2C+ and CD16+CD56- human natural killer cells. NKG2C+ cells proliferate in response to human cytomegalovirus (HCMV) and expansion of the dysfunctional CD56-CD16+ natural killer (NK) cells is ...
Bower, Mark, Gazzard, Brian G, Goodier, Martin R, Gregson, John NS, Kuri-Cervantes, Leticia, Mela, Christopher M   +5 more
core   +1 more source

Nano‐Flow Cytometry‐Guided Discrimination and Separation of Human Cytomegalovirus Virions and Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 14, Issue 5, May 2025.
Graphical illustration of the nano‐flow cytometry‐based method for the discrimination of HCMV virions, dense bodies, and extracellular vesicles. Extracellular particles found in the conditioned medium of HCMV‐infected cells are stained with a nucleic acid dye (such as SYBR Green I), and forced into a single‐particle stream. Single particles are excited
Vladimir Bokun, Blair L. Strang, Paschalia Pantazi, Yan Liu, Beth Holder   +4 more
wiley   +1 more source

Kinome Profiling Identifies Druggable Targets for Novel Human Cytomegalovirus (HCMV) Antivirals*

Molecular & Cellular Proteomics, 2017
Human cytomegalovirus (HCMV) is a significant cause of disease in immune-compromised adults and immune naïve newborns. No vaccine exists to prevent HCMV infection, and current antiviral therapies have toxic side effects that limit the duration and ...
Kyle C. Arend, Erik M. Lenarcic, Heather A. Vincent, N. Rashid, E. Lazear, Ian M. McDonald, T. S. Gilbert, Michael P. East, Laura E. Herring, G. Johnson, L. Graves, Nathaniel J. Moorman   +11 more
semanticscholar   +1 more source

Human Cytomegalovirus Antigen Presentation by HLA‐G in Infected Cells

HLA, Volume 105, Issue 5, May 2025.
ABSTRACT HLA‐E and ‐G class Ib molecules were considered unrelated to viral antigen presentation. HLA‐E binds nonamers from the leader sequences of other HLA‐I molecules and the human cytomegalovirus (HCMV) UL40 protein, interacting with CD94/NKG2 NK cell receptors.
Mireia Altadill, Iñaki Álvarez, Michelle Ataya, Gemma Heredia, Elisenda Alari‐Pahissa, Aura Muntasell, Manuel Llano, Jonas Fuchs, Carlos Vilches, Hartmut Hengel, Anne Halenius, Miguel López‐Botet   +11 more
wiley   +1 more source

Structure of HCMV glycoprotein B in the postfusion conformation bound to a neutralizing human antibody

Nature Communications, 2015
Human cytomegalovirus (HCMV) poses a significant threat to immunocompromised individuals and neonates infected in utero. Glycoprotein B (gB), the herpesvirus fusion protein, is a target for neutralizing antibodies and a vaccine candidate due to its ...
S. Chandramouli, C. Ciferri, P. Nikitin, Stefano Caló, Rachel Gerrein, Kara Balabanis, J. Monroe, C. Hebner, A. Lilja, E. Settembre, A. Carfi   +10 more
semanticscholar   +1 more source

Endogenous human cytomegalovirus gB is efficiently presented by MHC class II molecules to CD4+ CTL [PDF]

, 2005
Human cytomegalovirus (HCMV) infects endothelial, epithelial, and glial cells in vivo. These cells can express MHC class II proteins, but are unlikely to play important roles in priming host immunity.
Dunn, C, Hegde, NR, Jarvis, MA, Johnson, DC, Lewinsohn, DM, Nelson, JA   +5 more
core