Results 91 to 100 of about 44,631 (298)

Artificial Intelligence‐Driven Proteomics Identifies Plasma Protein Signatures for Diagnosis and Stratification of Behçet's Disease

Advanced Science, EarlyView.
Molecular and functional landscape of BD progression and severity based on in‐depth proteomics. Tree boosting machine learning models with favorable performance in BD diagnosis and stratification. Efficient biomarker panels for BD diagnosis and stratification. .
Linlin Cheng, Mansheng Li, Zhou Bai, Xiaobo Yu, Wenjie Zheng, Yongzhe Li, Yudong Liu   +6 more
wiley   +1 more source

Development of novel vaccines against human cytomegalovirus

Human Vaccines & Immunotherapeutics, 2019
Congenital human cytomegalovirus (HCMV) infection and HCMV infection of the immunosuppressed patients cause significant morbidity and mortality, and vaccine development against HCMV is a major public health priority. Efforts to develop HCMV vaccines have
Xinle Cui, Clifford M. Snapper
doaj   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Single Chain Antibodies Against gp55 of Human Cytomegalovirus (HCMV) for Prophylaxis and Treatment of HCMV Infections [PDF]

Jundishapur Journal of Microbiology, 2016
Immunotherapy is a promising prospective new treatment for cytomegalovirus (CMV) infections. Neutralizing effects have been reported using monoclonal antibodies. Recombinant single chain antibodies (scFvs) due to their advantages over monoclonal antibodies are potential alternatives and provide valuable clinical agents.The aim of this study was to ...
Foroogh Nejatollahi, Bahareh Moazen, Elahe Ebrahimi   +2 more
openaire   +3 more sources

High-Risk Oncogenic Human Cytomegalovirus

Viruses, 2022
Human cytomegalovirus (HCMV) is a herpesvirus that infects between 40% and 95% of the population worldwide, usually without symptoms. The host immune response keeps the virus in a latent stage, although HCMV can reactivate in an inflammatory context ...
Georges Herbein
doaj   +1 more source

Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex [PDF]

, 2017
Human cytomegalovirus (HCMV) is the leading cause of congenital viral infection, and developing a prophylactic vaccine is of high priority to public health.
Adler, Stuart P., An, Zhiqiang, DePhillips, Pete A., Freed, Daniel C., Fu, Tong-Ming, Ha, Sha, Hamm, Melissa, Li, Fengsheng, Loughney, John W., McLellan, Jason S., McVoy, Michael A., Nickle, David C., Rustandi, Richard R., Tang, Aimin, Troutman, Matthew C., Vlasak, Josef, Wang, Dai, Wang, I-Ming, Zhang, Ningyan, Zhu, Hua   +19 more
core   +3 more sources

Primary Human Cytomegalovirus (HCMV) Infection in Pregnancy.

Deutsches Ärzteblatt International, 2017
BACKGROUND In 0.5-4% of pregnancies, the prospective mother sustains a primary infection with human cytomegalovirus (HCMV). An HCMV infection of the fetus in the first or second trimester can cause complex post-encephalitic impairment of the infant brain,
H. Buxmann, K. Hamprecht, M. Meyer-Wittkopf, K. Friese   +3 more
semanticscholar   +1 more source

Dominant‐Negative Effects of p53 R337 Variants in Li–Fraumeni Syndrome: Impact on Tetramer Formation and Transcriptional Activity

ChemBioChem, EarlyView.
Hetero‐tetramer dysfunction: Li–Fraumeni syndrome (LFS) is a hereditary cancer predisposition caused by mutations in the TP53 gene encoding the tumor suppressor p53. It is shown that p53 variants R337C and R337H, found in LFS, impair wild‐type (WT) p53 function by forming heterotetramers with reduced transcriptional activity.
Rui Kamada, Shuya Sakaguchi, Madoka Kanno, Takaaki Ozawa, Natsumi Nakagawa, James G. Omichinski, Kazuyasu Sakaguchi   +6 more
wiley   +1 more source

Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development. [PDF]

, 2019
Cytomegalovirus (CMV) infection causes birth defects and life-threatening complications in immunosuppressed patients. Lack of vaccine and need for more effective drugs have driven widespread ongoing therapeutic development efforts against human CMV (HCMV)
Balogun, Rilwan, Chan, Karen, Dai, Xinghong, Jih, Jonathan, Liu, Fenyong, Liu, Wei, Mei, Ye, Trang, Phong, Yu, Xuekui, Zhou, Z Hong   +9 more
core   +2 more sources

Current Progress in Targeting Human Cytomegalovirus Infection

iLABMED, EarlyView.
This review highlights recent advances in the mechanisms by which human cytomegalovirus (HCMV) maintains its genome in infected cells, as well as the cellular factors and viral antigens that modulate viral reactivation, which reveal potential targets for addressing HCMV infection.
Yonggang Pei, Jun Chen
wiley   +1 more source