Results 101 to 110 of about 44,631 (298)
Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors
Frontiers in Pharmacology, 2015 Human herpesviruses are widespread infectious pathogens that have been associated with proliferative and inflammatory diseases. During viral evolution, human herpesviruses have pirated genes encoding viral G protein-coupled receptors (vGPCRs), which are ...
Sabrina M de Munnik +3 more
doaj +1 more source
Human cytomegalovirus Fcγ binding proteins gp34 and gp68 antagonize Fcγ receptors I, II and III. [PDF]
PLoS Pathogens, 2014 Human cytomegalovirus (HCMV) establishes lifelong infection with recurrent episodes of virus production and shedding despite the presence of adaptive immunological memory responses including HCMV immune immunoglobulin G (IgG).
Eugenia Corrales-Aguilar +11 more
doaj +1 more source
Expression of the murine cytomegalovirus glycoprotein H by recombinant vaccinia virus [PDF]
, 1994 The sequence of the gene encoding glycoprotein H (gH) of murine cytomegalovirus (MCMV) strain Smith was determined and compared with the sequence of the gH of MCMV strain K181. Transcriptional analysis showed that gH is encoded by a large mRNA of 5.0 kb,
Koszinowski, Ulrich H. +4 more
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The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts
Viruses, 2018 Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus for which there is no vaccine or cure. This viral infection, once acquired, is life-long, residing latently in hematopoietic cells.
M. Nukui, C. O’Connor, Eain A. Murphy
semanticscholar +1 more source
Mapping protein–protein interactions by mass spectrometry
Mass Spectrometry Reviews, EarlyView.Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu +4 more
wiley +1 more source
MECHANISMS OF IMMUNOLOGICAL TOLERANCE DISRUPTION
Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2016 Autoimmune diseases belong to disorders with an unclear etiology. The spectrum of autoimmune diseases is wide, the most well known of them are type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, Crohn’s disease ...
Polina Kravchenko, Evgenia Oleinik
doaj +1 more source
Viruses, 2018 Immunoglobulins are only moderately effective for the treatment of human cytomegalovirus (HCMV) infections, possibly due to ineffectiveness against cell-associated virus spread.
J. Falk +9 more
semanticscholar +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro +5 more
wiley +1 more source
CD1d expression and invariant NKT cell responses in herpesvirus infections
Frontiers in Immunology, 2015 Invariant natural killer T (iNKT) cells are a highly conserved subset of unconventional T lymphocytes that express a canonical, semi-invariant T cell receptor (TCR) and surface markers shared with the natural killer cell lineage.
Rusung eTan
doaj +1 more source
Sustained gene expression in the retina by improved episomal vectors [PDF]
, 2014 Gene and cellular therapies are nowadays part of therapeutic strategies for the treatment of diverse pathologies. The drawbacks associated with gene therapy-low levels of transgene expression, vector loss during mitosis, and gene silencing-need to be ...
Ana V. Oliveira +7 more
core +1 more source