Results 111 to 120 of about 44,949 (257)

Monoubiquitination of syntaxin 3 leads to retrieval from the basolateral plasma membrane and facilitates cargo recruitment to exosomes [PDF]

, 2017
Syntaxin 3 (Stx3), a SNARE protein located and functioning at the apical plasma membrane of epithelial cells, is required for epithelial polarity.
Adrian J. Giovannone, Alberto Fraile-Ramos, Alenquer M, Barbieri MA, Bezprozvanny I, Bilodeau PS, Breuza L, Britt WJ, Calistri A, Campeau E, Castle AM, Cepeda V, Cepeda V, Chin LS, Clague MJ, Danielsen JM, Delgrossi MH, Dragovic RA, Elena Reales, Fowler KB, Fraile-Ramos A, Fraile-Ramos A, Fujita H, Geng L, Gong Q, Gonzales PA, Guo X, Guo Z, Hackam DJ, Henne WM, Hibi T, Hicke L, Hislop JN, Hong W, Huang F, Huang S, Hurley JH, Jahn R, Kamsteeg EJ, Keith E. Mostov, Kim W, Kwon SH, Kyuuma M, Lakkaraju A, Leung YM, Li X, Liu ST, Low SH, Marchese A, McCullough J, McSharry BP, Meckes DG, Moffat J, Mori Y, Na CH, Naldini L, Naren AP, Olkkonen VM, Ostrowski M, Pallavi Bhattaram, Pawliczek T, Raiborg C, Raiborg C, Ren J, Riento K, Rodriguez-Boulan E, Rothman JE, Sharma N, Shields SB, Shih SC, Simons M, Singer-Lahat D, Somsel Rodman J, Stringer DK, Sudhof TC, Tandon R, ter Beest MB, Thery C, Thomas Weimbs, van Niel G, Weimbs T, Weimbs T, Weimbs T, Wickner W, Wojcikiewicz RJ, Yatsu A, Zerial M   +86 more
core   +3 more sources

The Bioengineering of Microspheric Skin Organoids and Their Application in Drug Screening

Advanced Science, Volume 12, Issue 22, June 12, 2025.
A novel method for the preparation of uniform microspheric skin organoids via spinning bioreactors is developed. The organoid consists of a core‐shell structure to mimic the bilayered skin structure with the epidermis on the surface. For efficient drug screening, the organoid is equipped with a luciferase reporter to detect canonical Wnt signaling, and
Jundong Xie, Qingyang Yang, Yanan Zhang, Ke Zheng, Hongya Geng, Yaojiong Wu   +5 more
wiley   +1 more source

Human Cytomegalovirus Infection Upregulates the Mitochondrial Transcription and Translation Machineries

mBio, 2016
Infection with human cytomegalovirus (HCMV) profoundly affects cellular metabolism. Like in tumor cells, HCMV infection increases glycolysis, and glucose carbon is shifted from the mitochondrial tricarboxylic acid cycle to the biosynthesis of fatty acids.
S. Karniely, M. P. Weekes, R. Antrobus, J. Rorbach, L. van Haute, Y. Umrania, D. L. Smith, R. J. Stanton, M. Minczuk, P. J. Lehner, J. H. Sinclair   +10 more
doaj   +1 more source

Memory NK cell features exploitable in anticancer immunotherapy [PDF]

, 2019
Besides their innate ability to rapidly produce effector cytokines and kill virus-infected or transformed cells, natural killer (NK) cells display a strong capability to adapt to environmental modifications and to differentiate into long-lived ...
Battella, Simone, Capuano, Cristina, Galandrini, Ricciarda, Palmieri, Gabriella, Pighi, Chiara, Santoni, Angela   +5 more
core   +2 more sources

Kinome Profiling Identifies Druggable Targets for Novel Human Cytomegalovirus (HCMV) Antivirals*

Molecular & Cellular Proteomics, 2017
Human cytomegalovirus (HCMV) is a significant cause of disease in immune-compromised adults and immune naïve newborns. No vaccine exists to prevent HCMV infection, and current antiviral therapies have toxic side effects that limit the duration and ...
Kyle C. Arend, Erik M. Lenarcic, Heather A. Vincent, N. Rashid, E. Lazear, Ian M. McDonald, T. S. Gilbert, Michael P. East, Laura E. Herring, G. Johnson, L. Graves, Nathaniel J. Moorman   +11 more
semanticscholar   +1 more source

The Complex Role of CD8+ T Cells in Placental HIV Infection

European Journal of Immunology, Volume 55, Issue 6, June 2025.
CD8+ T cells exhibit dual roles at the maternal‐fetal interface supporting tolerance via IL‐10 and TGF‐β and aiding implantation and vascular remodeling through TNF‐α and IFN‐γ. In HIV infection, CD8+ T cells expand, driving inflammation, PD‐L1 upregulation on trophoblasts, and cytotoxic dysfunction via reduced Granzyme B and Perforin, compromising ...
Kimberly Peta, Mushi Matjila, Nadia Ikumi   +2 more
wiley   +1 more source

Immune reconstitution of human cytomegalovirus-specific T lymphocytes after allogeneic hematopoietic stem cell transplantation and their predictive role in reactivation

Frontiers in Immunology
Human cytomegalovirus (HCMV) is the most common virus to affect the recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT). HCMV reactivation increases the risk of secondary fungal and bacterial infections, as well as that of non ...
Yuanqi Zhao, Yuanqi Zhao, Yuanqi Zhao, Sisi Zhen, Sisi Zhen, Jiali Wang, Jiali Wang, Jieru Wang, Jieru Wang, Runzhi Ma, Runzhi Ma, Li Liu, Li Liu, Aiming Pang, Aiming Pang, Rongli Zhang, Rongli Zhang, Xin Chen, Xin Chen, Weihua Zhai, Weihua Zhai, Donglin Yang, Donglin Yang, Yi He, Yi He, Mingzhe Han, Mingzhe Han, Erlie Jiang, Erlie Jiang, Sizhou Feng, Sizhou Feng   +30 more
doaj   +1 more source

Structure of HCMV glycoprotein B in the postfusion conformation bound to a neutralizing human antibody

Nature Communications, 2015
Human cytomegalovirus (HCMV) poses a significant threat to immunocompromised individuals and neonates infected in utero. Glycoprotein B (gB), the herpesvirus fusion protein, is a target for neutralizing antibodies and a vaccine candidate due to its ...
S. Chandramouli, C. Ciferri, P. Nikitin, Stefano Caló, Rachel Gerrein, Kara Balabanis, J. Monroe, C. Hebner, A. Lilja, E. Settembre, A. Carfi   +10 more
semanticscholar   +1 more source

The Story of Human Cytomegalovirus and Cancer: Increasing Evidence and Open Questions

Neoplasia: An International Journal for Oncology Research, 2009
Although human cytomegalovirus (HCMV) is generally not regarded to be an oncogenic virus, HCMV infection has been implicated in malignant diseases from different cancer entities.
Martin Michaelis, Hans W. Doerr, Jindrich Cinatl, Jr   +2 more
doaj   +1 more source

A long and complex enhancer activates transcription of the gene coding for the highly abundant immediate early mRNA in murine cytomegalovirus [PDF]

, 1985
Using the simian virus 40 "enhancer trap" approach, we have identified a transcription enhancer located just upstream of the major immediate early gene of murine cytomegalovirus. This enhancer has several striking properties.
Dorsch-Häsler, Karoline, Jasin, Maria, Keil, Günther M., Koszinowski, Ulrich H., Schaffner, Walter, Weber, Frank   +5 more
core   +1 more source