Results 191 to 200 of about 28,017 (205)

Unusual escape for HCMV

Nature Reviews Microbiology, 2011
A new paper reveals that HCMV can escape a neutralizing antibody by incorporating it into assembling virions.
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Methods in Anti-HCMV Research

2003
The study of strategies for the treatment of human cytomegalovirus (HCMV) infection starts with the discovery of compounds that are potent and selective inhibitors of HCMV replication. Selectivity means that the window between the concentrations that block viral replication on the one hand and those that affect host cell functions on the other is ...
Erik De Clercq, Johan Neyts, Astrid Meerbach, Robert Snoeck, Graciela Andrei   +4 more
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Human cytomegalovirus (HCMV) genotype populations in immunocompetent individuals during primary HCMV infection

Journal of Clinical Virology, 2010
Immunocompetent individuals can harbor multiple human cytomegalovirus (HCMV) genotypes. However, little is known about the genotype populations acquired during primary HCMV infection.The aim of this study was to assess the HCMV genotype populations present in the blood of non-immunocompromised patients experiencing primary HCMV infection.HCMV ...
Irene Görzer, Monika Redlberger-Fritz, Elisabeth Puchhammer-Stöckl, Heidrun Kerschner   +3 more
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Models of HCMV latency and reactivation

Trends in Microbiology, 2003
Human cytomegalovirus (HCMV) is a ubiquitous β-herpesvirus that causes severe disease primarily in immunosuppressed individuals. A major characteristic of HCMV, with obvious clinical importance, is its ability to establish lifelong infection within the host following the initial acute infection.
Daniel N. Streblow, Jay A. Nelson
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Tetherin lets HCMV in [PDF]

Nature Reviews Microbiology, 2011
Tetherin (also known as BST2) is known to inhibit the release of numerous enveloped viruses. Surprisingly, this study shows that, in the case of human cytomegalovirus (HCMV), tetherin has a beneficial role for the virus, enhancing its entry into the host cell. Cells induced to stably express tetherin showed higher HCMV infection levels than controls in
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Role of human cytomegalovirus (HCMV)-specific antibody in HCMV-infected pregnant women

Early Human Development, 2014
Maternal preconception immunity confers substantial protection against HCMV infection and disease to the unborn child. However, the protective role played by single components of virus-specific humoral and cellular immunity is poorly defined. Recently, it was discovered that UL128-131 gene products are essential for the virus to exert endothelial ...
Paola Zelini, Maria Grazia Revello, Alessia Arossa, Daniele Lilleri, Chiara Fornara   +4 more
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Diagnosis and prognostic markers of HCMV infection

Journal of Clinical Virology, 2001
Human cytomegalovirus (HCMV) infections are frequently observed as well in immunocompetent as in immunocompromised patients. Diagnostic techniques for HCMV detection have greatly improved during the recent years. Detection of HCMV by culture has been bettered by centrifugating samples in a shell vial and by using monoclonal antibody to the immediate ...
Denis Cointe, Liliane Grangeot-Keros
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HCMV microinfections in inflammatory diseases and cancer

Journal of Clinical Virology, 2008
Human cytomegalovirus (HCMV) is a wide-spread human virus that was mainly known to cause disease in immunocompromised patients. A new entity of infection can be diagnosed with high sensitive techniques; HCMV microinfections that often exhibit an altered pattern of IE protein expression.
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Entry route of HCMV into endothelial cells

Journal of Clinical Virology, 2008
Human cytomegalovirus (HCMV) is generally assumed to enter its target cells by direct fusion at the plasma membrane while sequestration and lysis of viral particles within endocytic vesicles has been suggested as an abortive entry pathway of fibroblast-adapted HCMV strains in endothelial cells.
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Breastfeeding and HCMV-Infection in the Preterm Infant

Das Gesundheitswesen, 2008
R. Goelz, K. Hamprecht
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