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Adoptive immunotherapy of HCMV infection
Cytotherapy, 2007Human cytomegalovirus (HCMV) infection or reactivation is a frequent cause of morbidity and mortality in immunocompromised individuals such as transplant recipients. Primary HCMV infection or reactivation of HCMV from latency is mostly asymptomatic in immunocompetent individuals and is controlled by the host's cell-mediated immune response.
M, Kapp +3 more
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Journal of Clinical Virology, 2010
Immunocompetent individuals can harbor multiple human cytomegalovirus (HCMV) genotypes. However, little is known about the genotype populations acquired during primary HCMV infection.The aim of this study was to assess the HCMV genotype populations present in the blood of non-immunocompromised patients experiencing primary HCMV infection.HCMV ...
Irene, Görzer +3 more
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Immunocompetent individuals can harbor multiple human cytomegalovirus (HCMV) genotypes. However, little is known about the genotype populations acquired during primary HCMV infection.The aim of this study was to assess the HCMV genotype populations present in the blood of non-immunocompromised patients experiencing primary HCMV infection.HCMV ...
Irene, Görzer +3 more
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Nature Reviews Immunology, 2018
Strain-specific recognition of different UL40 peptides determines the proliferation and activation of NKG2C+ NK cells during HCMV infection.
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Strain-specific recognition of different UL40 peptides determines the proliferation and activation of NKG2C+ NK cells during HCMV infection.
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Role of human cytomegalovirus (HCMV)-specific antibody in HCMV-infected pregnant women
Early Human Development, 2014Maternal preconception immunity confers substantial protection against HCMV infection and disease to the unborn child. However, the protective role played by single components of virus-specific humoral and cellular immunity is poorly defined. Recently, it was discovered that UL128-131 gene products are essential for the virus to exert endothelial ...
Maria Grazia, Revello +4 more
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2003
The study of strategies for the treatment of human cytomegalovirus (HCMV) infection starts with the discovery of compounds that are potent and selective inhibitors of HCMV replication. Selectivity means that the window between the concentrations that block viral replication on the one hand and those that affect host cell functions on the other is ...
J, Neyts +4 more
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The study of strategies for the treatment of human cytomegalovirus (HCMV) infection starts with the discovery of compounds that are potent and selective inhibitors of HCMV replication. Selectivity means that the window between the concentrations that block viral replication on the one hand and those that affect host cell functions on the other is ...
J, Neyts +4 more
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Models of HCMV latency and reactivation
Trends in Microbiology, 2003Human cytomegalovirus (HCMV) is a ubiquitous β-herpesvirus that causes severe disease primarily in immunosuppressed individuals. A major characteristic of HCMV, with obvious clinical importance, is its ability to establish lifelong infection within the host following the initial acute infection.
Daniel N, Streblow, Jay A, Nelson
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Journal of Clinical Virology, 2010
Cytomegalovirus (HCMV) remains an important infection following stem cell transplantation (SCT) and is managed via pre-emptive therapy. In some patients HCMV loads continue to increase after therapy and they experience multiple episodes of replication.To identify the risk factors associated with failure to immediately control HCMV replication after ...
Hubertus C E, Buyck +2 more
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Cytomegalovirus (HCMV) remains an important infection following stem cell transplantation (SCT) and is managed via pre-emptive therapy. In some patients HCMV loads continue to increase after therapy and they experience multiple episodes of replication.To identify the risk factors associated with failure to immediately control HCMV replication after ...
Hubertus C E, Buyck +2 more
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Dendritic Cells and HCMV Cross-Presentation
2003The outcome of a viral infection is the result of an endless fight between the organism whose task is to mount an antiviral response and the virus that adapts strategies to circumvent the host response. Human cytomegalovirus (HCMV), a latent herpesvirus, can be considered as a spearhead in exploiting co-existence with the host to develop numerous ...
G, Arrode, C, Davrinche
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Human cytomegalovirus (HCMV) infection/re-infection: development of a protective HCMV vaccine.
The new microbiologica, 2019In recent years, one of the main objectives in the field of medical virology has been the development of a human cytomegalovirus (HCMV) vaccine that can prevent congenital HCMV infection in the offspring of pregnant women as well as systemic and end-organ disease in immunocompromised (AIDS and transplanted) patients.
Giuseppe, Gerna, Daniele, Lilleri
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