Results 81 to 90 of about 46,134 (291)

Reduced progression of bone erosion in cytomegalovirus seropositive rheumatoid arthritis patients

Arthritis Research & Therapy, 2020
Background Human cytomegalovirus (HCMV) seropositivity has been associated with higher inflammation during rheumatoid arthritis (RA). However, no data are available on the impact of HCMV seropositivity on bone erosion progression during RA.
B. Rauwel, Y. Degboé, D. Nigon, J.-F. Boyer, F. Abravanel, J. Izopet, B. Combe, A. Ruyssen-Witrand, A. Constantin, A. Cantagrel, J.-L. Davignon   +10 more
doaj   +1 more source

The role of IFN-gamma in Humoral immune response for HCMV antigens among pregnant women

Al-Kitab Journal for Pure Sciences, 2023
Background: Human cytomegalovirus (HCMV) is a highly host-specific virus belongs to the β-herpesvirus subfamily, which is a leading cause of congenital infections.
Staar Mohammed Qader, Sanarya Kamal Tawfiq   +1 more
doaj   +1 more source

The Core Histone-binding Region of the Murine Cytomegalovirus 89K Immediate Early Protein [PDF]

, 1991
The gene regulatory immediate early protein, pp89, of murine cytomegalovirus interacts with both DNA-associated and isolated histones in vitro. We characterized the histone-binding region of pp89 and its cellular localization during cell division to ...
Bühler, Bernhard, Koszinowski, Ulrich H., Messerle, Martin, Münch, Konrad   +3 more
core   +1 more source

Memory NK cell features exploitable in anticancer immunotherapy [PDF]

, 2019
Besides their innate ability to rapidly produce effector cytokines and kill virus-infected or transformed cells, natural killer (NK) cells display a strong capability to adapt to environmental modifications and to differentiate into long-lived ...
Battella, Simone, Capuano, Cristina, Galandrini, Ricciarda, Palmieri, Gabriella, Pighi, Chiara, Santoni, Angela   +5 more
core   +2 more sources

Role of Immunogenetics in the Outcome of HCMV Infection: Implications for Ageing

International Journal of Molecular Sciences, 2019
The outcome of host-virus interactions is determined by a number of factors, some related to the virus, others to the host, such as environmental factors and genetic factors.
A. Aiello, G. Accardi, G. Candore, C. Caruso, C. Colomba, D. Di Bona, G. Duro, C. Gambino, M. E. Ligotti, J. Pandey   +9 more
semanticscholar   +1 more source

EGR Proteins Mediate Interferon‐Independent Anti‐HSV‐1 Responses Through Viral and Host Targets

Advanced Science, EarlyView.
Early antiviral responses are typically mediated by interferons. However, during HSV‐1 infection, host early growth response (Egr) genes, which are not interferon‐stimulated genes, are quickly induced by viral protein ICP0. EGR proteins, in turn, suppress viral lytic infection by activating viral latency‐associated (LAT) and host immune regulatory ...
Shuaishuai Wang, Fujun Hou, Xunuo Jin, Yuhang Xiang, Dongli Pan   +4 more
wiley   +1 more source

The Inhibition of miR-144-3p on Cell Proliferation and Metastasis by Targeting TOP2A in HCMV-Positive Glioblastoma Cells

Molecules, 2018
Glioblastoma (GBM), the most common type of primary tumor in the central nervous system, is a very aggressive brain tumor with poor prognosis and a high recurrence rate.
Jing-yi Song, Q. Ma, Ming Hu, D. Qian, Bin Wang, Ningning He   +5 more
semanticscholar   +1 more source

Artificial intelligence strategies for predicting kinase inhibitor resistance: A comprehensive review of methods, challenges, and future perspectives

Journal of Intelligent Medicine, EarlyView.
Abstract Kinase inhibitors are essential in targeted cancer therapy, yet resistance often emerges through secondary mutations, activation of compensatory signaling pathways, or drug‐efflux mechanisms. Artificial intelligence (AI) provides a workflow‐based strategy rather than a list of unrelated tools for predicting and addressing kinase‐inhibitor ...
Faris Hassan, Mohanad Ali Deifallah, Alaa Zaghloul, Rania Elgohary   +3 more
wiley   +1 more source

Human Cytomegalovirus (HCMV) UL82 Gene Product (pp71) Relieves hDaxx-Mediated Repression of HCMV Replication [PDF]

Journal of Virology, 2006
ABSTRACT This study examines the role of the cellular protein hDaxx in controlling human cytomegalovirus (HCMV) immediate-early (IE) gene expression and viral replication. Using permissive cell lines that either overexpress hDaxx or are depleted of hDaxx expression by the use of short hairpin RNA, we demonstrate that hDaxx functions as a ...
Stacy R, Cantrell, Wade A, Bresnahan
openaire   +2 more sources

Tumor-Targeting Anti-CD20 Antibodies Mediate In Vitro Expansion of Memory Natural Killer Cells: Impact of CD16 Affinity Ligation Conditions and In Vivo Priming [PDF]

, 2018
Natural Killer (NK) cells represent a pivotal player of innate anti-tumor immune responses. The impact of environmental factors in shaping the representativity of different NK cell subsets is increasingly appreciated.
Angela Santoni, Angela Santoni, Angela Santoni, Chiara Pighi, Cristina Capuano, Gabriella Palmieri, Lavinia Franchitti, Ombretta Turriziani, Ricciarda Galandrini, Simone Battella, Stefania Morrone   +10 more
core   +2 more sources