Lymphoproliferative Response in Primary Human Cytomegalovirus (HCMV) Infection Is Delayed in HCMV Transmitter Mothers [PDF]
The Journal of Infectious Diseases, 2006 The T cell-mediated immune response to human cytomegalovirus (HCMV) after primary infection, as well as the determinants of intrauterine transmission, are poorly understood.Sequential peripheral blood leukocyte samples from 74 pregnant women and 29 nonpregnant individuals with primary infection were examined for HCMV-specific CD4+ T cells by cytokine ...
Giuseppe Gerna +6 more
openaire +3 more sources
Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development. [PDF]
, 2019 Cytomegalovirus (CMV) infection causes birth defects and life-threatening complications in immunosuppressed patients. Lack of vaccine and need for more effective drugs have driven widespread ongoing therapeutic development efforts against human CMV (HCMV)
Balogun, Rilwan +9 more
core +2 more sources
Interaction between HCMV pUL83 and human AIM2 disrupts the activation of the AIM2 inflammasome
Virology Journal, 2017 AIM2, a cytosolic DNA sensor, plays an important role during infection caused by pathogens with double-stranded DNA; however, its role in human cytomegalovirus (HCMV) infection remains unclear.
Yuan-Chung Huang +7 more
semanticscholar +1 more source
The Human Cytomegalovirus (HCMV) Tegument Protein UL94 Is Essential for Secondary Envelopment of HCMV Virions [PDF]
Journal of Virology, 2012 ABSTRACT Human cytomegalovirus (HCMV) virions are structurally complex, and the mechanisms by which they are assembled are poorly understood. However, several tegument proteins are known to be essential for proper particle assembly and maturation. Despite intense investigation, the function of many tegument proteins remains unknown.
Stacia L. Phillips, Wade A. Bresnahan
openaire +3 more sources
The Human Cytomegalovirus Fc Receptor gp68 Binds the Fc CH2-CH3 Interface of Immunoglobulin G [PDF]
, 2008 Recognition of immunoglobulin G (IgG) by surface receptors for the Fc domain of immunoglobulin G (Fc{gamma}), Fc{gamma}Rs, can trigger both humoral and cellular immune responses.
Bjorkman, Pamela J. +6 more
core +3 more sources
Cellular Physiology and Biochemistry, 2016 Background/Aims: Rho GTPases are crucial regulators of the actin cytoskeleton, membrane trafficking and cell signaling and their importance in cell migration and invasion is well- established.
Melpomeni Tseliou +5 more
semanticscholar +1 more source
Bayesian Nonparametric Variable Selection as an Exploratory Tool for Finding Genes that Matter [PDF]
arXiv, 2010 High-throughput scientific studies involving no clear a'priori hypothesis are common. For example, a large-scale genomic study of a disease may examine thousands of genes without hypothesizing that any specific gene is responsible for the disease. In these studies, the objective is to explore a large number of possible factors (e.g.
arxiv
Opportunities to Modulate Tumor Ecosystem Toward Successful Glioblastoma Immunotherapy
Cancer Science, Volume 116, Issue 6, Page 1482-1499, June 2025.There remain outstanding gaps between the negative results from clinical trials and the actual potential of the immune system for glioblastoma. To bridge this crucial gap, we collaborated with Dr. Mariko Takahashi, an expert in immunobiology and drug development, and Dr. James J.
Mariko Takahashi +5 more
wiley +1 more source
HHEX: A Crosstalker between HCMV Infection and Proliferation of VSMCs
Frontiers in Cellular and Infection Microbiology, 2016 Objective: The study was designed to evaluate the role of Human cytomegalovirus (HCMV) infection on homebox (HOX) gene expression and the effects of overexpression of HOX genes on proliferation and apoptosis of vascular smooth muscle cells (VSMCs ...
Lingfang Li +9 more
semanticscholar +1 more source
Increased HCMV seroprevalence in patients with hepatocellular carcinoma [PDF]
Virology Journal, 2011 Abstract Background Hepatocellular carcinoma (HCC) is the most common primary liver cancer, usually arising after years of chronic liver inflammation that could result from viral infections such as hepatitis B virus (HBV) and hepatitic C virus (HCV) infections.
Lepiller, Quentin +4 more
openaire +5 more sources