Results 161 to 170 of about 36,523 (308)

Continuous Purification of mRNA Produced by In Vitro Transcription Using High Performance Countercurrent Membrane Purification

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Messenger ribonucleic acid (mRNA) therapeutics produced by in vitro transcription must be purified to remove residual enzymes and free nucleotides. This study examines the use of high‐performance countercurrent membrane purification (HPCMP) for the purification of mRNA therapeutics based on differences in the rate of diffusion across ...
Ziqiao Wang, Amin Javidanbardan, Ali Behboudi, Andrew L. Zydney   +3 more
wiley   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

Fouling‐Free Inertial Microfluidic Cell Clarification for Lentivirus Manufacturing

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Lentiviral vectors (LVVs) are widely used as gene‐delivery vehicles in cell and gene therapy, enabling stable integration of transgenes into target cells. However, efficient clarification of LVV harvest remains a major bottleneck in large‐scale manufacturing, as conventional depth filtration often results in significant product loss.
Dohyun Park, Alexander Bevacqua, Mingyang Cui, Marina Nichols, Jianzhu Chen, Jongyoon Han   +5 more
wiley   +1 more source

From brush conformation to 3D Supraparticles: Programmable self‐assembly of polymer‐grafted nanoparticles in emulsion confinement

Bulletin of the Korean Chemical Society, EarlyView.
This review highlights how the conformational adaptability of polymer‐grafted nanoparticles drives their programmable self‐assembly within 3D emulsion droplets. By coupling brush thermodynamics with soft confinement, these dynamic building blocks form hierarchical supraparticles tailored for advanced plasmonics, compartmentalized catalysis, and stimuli‐
Hongseok Yun
wiley   +1 more source

KI‐Doped α‐Mo2C Stably Catalyze Near‐Equilibrium CO2 to CO Beyond 1000 Hours

Carbon Energy, EarlyView.
Through iodine doping and effective stabilization of surface oxygen content, KI‐doped α‐Mo2C achieves a sustained equilibrium yield ratio of 0.95 over 1000 h at 400°C and 4 bar in reverse water–gas shift (RWGS) reaction. Furthermore, the catalyst has been successfully scaled up to the kilogram level, indicating considerable potential for industrial ...
Haipeng Wang, Chunshan Li, Zhiguo Lv, Tao Zhuang, Jinguang Hu, Fujin Sun, Chao Zhang   +6 more
wiley   +1 more source

Synergetic Heterophase and Selective Defect Engineering of Nano Multicomponent Alloys for Rechargeable Zn–Air Batteries

Carbon Energy, EarlyView.
An fcc/bcc with defects (bcc‐d) MCA is designed by utilizing the interplay between heterophase and selective defect engineering and exhibits excellent electrocatalytic activity suitable for high‐performance zinc–air batteries. The synergistic catalysis of the fcc/bcc‐d breaks the universal linear‐scaling relationships of adsorbed multi‐intermediates ...
Xiaowen Guo, Shilin Zhang, Jinjin Ban, Guoqin Cao, Shuai Guo, Fanfan Liu, Guosheng Shao, Junhua Hu   +7 more
wiley   +1 more source

Sonochemical Synthesis of Cobalt‐Oxo‐Cubanes as Redox‐Active Platform for Proton‐Coupled Electron Transfer

Chemistry – A European Journal, EarlyView.
A facile sonochemical method for rapid and gram‐scale synthesis of ligand‐tunable cobalt‐oxo‐cubanes is reported. Electrochemical studies reveal a Co4O4‐centered one‐electron oxidation and PCET pathway, while identifying Co2+ impurities as key disruptors of true cubane redox chemistry.
Satyapriya Nath, Amjath Nihal Thiruthimmal, Tapan Ping, Sankalpa N. Panda, Loknath Patro, Jeebanjyoti Mohapatra, B. L. Bhargava, Bikash Kumar Jena, Bishnu P. Biswal   +8 more
wiley   +1 more source

Sibling Involvement and Documentation in Pediatric Eating Disorder Care

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective When a young person has an eating disorder (ED), the entire family, including siblings, is affected. Despite recommendations in clinical guidelines and treatment manuals to involve and support siblings, little is known about how this is enacted and documented in practice.
Amalie Schumann, Elizabeth Rapa, Louise Dalton   +2 more
wiley   +1 more source

Perceptions, attitudes, behaviours and barriers towards obesity among people with obesity and health care professionals in Indonesia: An exploratory online survey. [PDF]

PLoS One
Soegondo S, Nugraha GI, Kurniawan F, Jannati AA, Tahapary DL.   +4 more
europepmc   +1 more source

A Review of Grain Boundaries: Formation Mechanism, Synthesis Strategy, and Application in Electrocatalysis

EcoEnergy, EarlyView.
An overview of grain boundary engineering in the field of electrocatalysis. ABSTRACT Key electrocatalytic reactions such as HER, OER, ORR, CO2RR, and NRR offer promising routes for storing renewable energy as chemical fuels. However, their widespread application is constrained due to the lack of highly active and stable catalysts. Grain boundaries (GBs)
Jingyu Gao, Fengming Zhou, Xinying Li, Ying Deng, Zexing Wu, Siyuan Feng, Yujing Zhu, Dan Zhang, Zhenyu Xiao   +8 more
wiley   +1 more source