Results 1 to 10 of about 6,006 (50)

MicroRNA-140-5p inhibits cellular proliferation, migration and invasion by downregulating AKT/STAT3/NF-κB pathway in breast carcinoma cells

Acta Pharmaceutica, 2022
MicroRNA-140-5p (miR-140-5p) plays a pivotal role in human cancers. However, its role and molecular mechanisms in breast carcinoma are not fully explored.
Hou Lingli, Liu Qi, Zhao Ying, Yang Hongwei, Meng Qingying, Yu Fei   +5 more
doaj   +1 more source

Direct oral anticoagulants (DOACs): From the laboratory point of view

Acta Pharmaceutica, 2022
Direct oral anticoagulants (DOACs) represent a new generation of drugs that have been increasingly used in the prevention and treatment of thromboembolic states.
Margetić Sandra, Goreta Sandra Šupraha, Ćelap Ivana, Razum Marija   +3 more
doaj   +1 more source

Poly(3-hydroxybutyrate): Promising biomaterial for bone tissue engineering

Acta Pharmaceutica, 2020
Poly(3-hydroxybutyrate) is a natural polymer, produced by different bacteria, with good biocompatibility and biodegradability. Cardiovascular patches, scaffolds in tissue engineering and drug carriers are some of the possible biomedical applications of ...
Dariš Barbara, Knez Željko
doaj   +1 more source

Modified release of furosemide from Eudragits® and poly(ethylene oxide)-based matrices and dry-coated tablets

Acta Pharmaceutica, 2020
Modified release of furosemide from tablet formulations is preferred by patients, because of physiological problems, acute diuresis being the most serious, compared to the forms designed for immediate release.
Vlachou Marilena, Geraniou Efthymia, Siamidi Angeliki   +2 more
doaj   +1 more source

Branched PLGA derivatives with tailored drug delivery properties

Acta Pharmaceutica, 2020
Despite several shortcomings such as extreme hydrophobicity, low drug capacity, characteristic triphasic drug release pattern with a high burst effect, poly(lactic-co-glycolic acid derivatives are widely used in drug delivery.
Snejdrova Eva, Podzimek Stepan, Martiska Juraj, Holas Ondrej, Dittrich Milan   +4 more
doaj   +1 more source

Neuroprotective effects of arbutin against oxygen and glucose deprivation-induced oxidative stress and neuroinflammation in rat cortical neurons

Acta Pharmaceutica, 2022
In this study, the neuroprotective potential of arbutin (100 µmol L−1) pre-treatment and post-treatment against oxygen/ glucose deprivation (OGD) and reoxygenation (R) induced ischemic injury in cultured rat cortical neurons was explored. The OGD (60 min)
Tan Jingjing, Yadav Manoj Kumar, Devi Sushma, Kumar Manish   +3 more
doaj   +1 more source

TLC-densitometric analysis of allantoin in Symphytum officinale L. roots

Acta Pharmaceutica, 2020
A TLC-densitometric method for determination of allantoin in Symphytum officinale root was developed. Densitometric quantification of allantoin was carried out on TLC Si60 plates with butanol-50 % methanol/formic acid, 66.5:33.2:0.3 (V/V/V) as developing
Kimel Katarzyna, Zienkiewicz Magdalena, Sparzak-Stefanowska Barbara, Krauze-Baranowska Mirosława   +3 more
doaj   +1 more source

A green approach to the analysis of co-administered ampicillin/sulbactam and paracetamol in human urine

Acta Pharmaceutica, 2022
The novelty of this work is the simultaneous analysis of sulbactam (SUL), ampicillin (AMP), and paracetamol (PARA) in human urine samples, using the environmentally benign RP-HPLC method.
SELIM BASMA M., ABDELSALAM RANDA A., EL-GINDY ALAA, EID BASMA G., NEAMATALLAH THIKRYAT, KHAYYAT AHDAB N., HADAD GHADA M., ELKHOUDARY MAHMOUD M.   +7 more
doaj   +1 more source

Anti-inflammatory and immunomodulatory effects of rosuvastatin in patients with low-to-moderate cardiovascular risk

Acta Pharmaceutica, 2022
Statins have shown anti-inflammatory pleiotropic effects in subjects with/at risk of cardiovascular disease. The aim of this study was to evaluate the inflammatory/immunomodulatory properties of rosuvastatin in subjects at low-to-moderate cardiovascular ...
VAVLUKIS ANA, VAVLUKIS MARIJA, DIMOVSKI ALEKSANDAR, PETRUSHEVSKA GORDANA, EFTIMOV ALEKSANDAR, DOMAZETOVSKA SASHKA, MLADENOVSKA KRISTINA   +6 more
doaj   +1 more source

An analytical “quality by design” approach in RP-HPLC method development and validation for reliable and rapid estimation of irinotecan in an injectable formulation

Acta Pharmaceutica, 2021
The objective of the present study was to develop a robust, simple, economical and sensitive HPLC-UV method using the “quality-by-design” approach for the estimation of irinotecan (IRI) in marketed formulations.
Bhaskaran Navya Ajitkumar, Kumar Lalit, Reddy M Sreenivasa, Pai Girish K   +3 more
doaj   +1 more source