Results 11 to 20 of about 5,787 (90)

Tryptanthrin exerts anti-breast cancer effects both in vitro and in vivo through modulating the inflammatory tumor microenvironment

open access: yesActa Pharmaceutica, 2021
Tryptanthrin is an indole quinazoline alkaloid from the indigo-bearing plants, such as Isatis indigotica Fort. Typically, this natural compound shows a variety of pharmacological activities such as antitumor, antibacterial, anti-inflammatory and ...
Zeng Qingfang   +6 more
doaj   +1 more source

Recent advancements to enhance the therapeutic efficacy of antiepileptic drugs

open access: yesActa Pharmaceutica, 2021
Epilepsy is a multifactorial neurological disorder characterized by recurrent or unprovoked seizures. Over the past two decades, many new antiepileptic drugs (AEDs) were developed and are in use for the treatment of epilepsy.
Li Fuquan, Singh Akhilesh Vikram
doaj   +1 more source

Differentiation of Pseudoprogression from True Progressionin Glioblastoma Patients after Standard Treatment: A Machine Learning Strategy Combinedwith Radiomics Features from T1-weighted Contrast-enhanced Imaging

open access: yesBMC Medical Imaging, 2021
Background Based on conventional MRI images, it is difficult to differentiatepseudoprogression from true progressionin GBM patients after standard treatment, which isa critical issue associated with survival.
Ying-Zhi Sun   +10 more
semanticscholar   +1 more source

A new RP-HPLC method as an auxiliary tool for optimization of sample preparation procedures for tracing of PPCPs of different hydrophilicities

open access: yesActa Pharmaceutica, 2021
Recently, pharmaceutical and personal care products (PPCPs) have received considerable attention because of their increasing use. Analysis of PPCPs presents a significant analytical challenge, with high-performance liquid chromatography (HPLC) in ...
Portillo-Castillo Omar J.   +6 more
doaj   +1 more source

Future prediction of existing glacial lake’s size in the Himalaya by Markov model and glacial surface topography

open access: yesAll Earth, 2023
Glacial lakes in the Himalayas are increasing in size and number at an alarming rate, with the majority of lakes concentrated in the eastern and central parts of the mountain range. This research focuses on the future prediction of regional-scale glacial
L. Mohanty   +3 more
semanticscholar   +1 more source

Qualitative and quantitative HPLC-ELSD-ESI-MS analysis of steroidal saponins in fenugreek seed

open access: yesActa Pharmaceutica, 2020
Fenugreek seeds are known as a source of various compounds, the most common of which are steroidal saponins. However, despite the growing interest in this plant material as a healing agent, spice and dietary supplement ingredient, the composition of ...
Król-Kogus Barbara   +2 more
doaj   +1 more source

Screening of six medicinal plant species for antileishmanial activity

open access: yesActa Pharmaceutica, 2021
This study is aimed to investigate the in vitro anti-leishmanial activity of ethanolic, aqueous or dichloromethane extracts of leaves, flowers, fruits or roots, of six medicinal plant species, namely, Nectandra megapotamica, Brunfelsia uniflora ...
Ferreira Fabiana Borges Padilha   +8 more
doaj   +1 more source

Sildenafil alters biogenic amines and increases oxidative damage in brain regions of insulin-hypoglycemic rats

open access: yesActa Pharmaceutica, 2020
The aim of the present study was to determine the effect of sildenafil on dopamine, 5-hydroxyindol acetic acid (5-HIAA) and selected biomarkers of oxidative stress in the brain of hypoglycemic rats.
Guzmán David Calderón   +6 more
doaj   +1 more source

Upregulation of p53 by tannic acid treatment suppresses the proliferation of human colorectal carcinoma

open access: yesActa Pharmaceutica, 2021
The present study’s objective is to clarify the molecular mechanisms of tannic acid effects on the viability of human colorectal carcinoma (CRC). Tannic acid is stable for up to 48 h and is localized in both cytoplasm and nucleus.
Karakurt Serdar   +2 more
doaj   +1 more source

Mental Health Effects on Job Retention in Indonesia

open access: yesJournal of Development Economics, 2023
This study examines the effect of mental health proxied by depression on job retention. The primary independent variable is the change in depression scores in 2007 and 2014.
M. Arizal, I. D. G. K. Wisana
semanticscholar   +1 more source

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