Results 51 to 60 of about 5,787 (90)

Side effects of retinoid therapy on the quality of vision

open access: yesActa Pharmaceutica, 2016
Retinoids are compounds chemically related to vitamin A, which are frequently used in dermatological practice (1). They are characterized by numerous mechanisms of action leading to normalization of keratinocyte proliferation and maturation.
Bergler-Czop Beata   +3 more
doaj   +1 more source

Charge transfer interaction of organic p-acceptors with the anti-hyperuricemic drug allopurinol: Insights from IR, Raman, 1H NMR and 13C NMR spectroscopies

open access: yesActa Pharmaceutica, 2016
The topic of charge-transfer (CT) complexation of vital drugs has attracted considerable attention in recent years owing to their significant physical and chemical properties.
Refat Moamen S.   +4 more
doaj   +1 more source

Pharmacoeconomic comparison of aripiprazole once-monthly and paliperidone palmitate from a head-to-head clinical trial in schizophrenia: a US analysis

open access: yesDrugs in Context, 2016
Schizophrenia presents a substantial clinical and economic burden to the health-care system. In QUAlity of LIfe with AbiliFY Maintena (QUALIFY), a randomized head-to-head study of aripiprazole once-monthly 400 mg (AOM 400) compared with paliperidone ...
C. Sapin   +5 more
semanticscholar   +1 more source

A study on blocking store-operated Ca2+ entry in pulmonary arterial smooth muscle cells with xyloketals from marine fungi

open access: yesActa Pharmaceutica, 2017
In this study, the effect of four xyloketals 1-4 on store-operated calcium entry (SOCE) was investigated in primary distal pulmonary arterial smooth muscle cells (PASMCs) isolated from mice.
Zhou Jie-Bin   +5 more
doaj   +1 more source

Comparative chemical investigation and evaluation of antioxidant and tyrosinase inhibitory effects of Withania somnifera (L.) Dunal and Solanum nigrum (L.) berries

open access: yesActa Pharmaceutica, 2018
In the present study, berries of two different species of Solanaceae family, Withania somnifera (WS) and Solanum nigrum (SN), were extracted in methanol and then fractionated with solvents, ranging from non-polar to polar, for their phytochemical ...
Hameed Abdul, Akhtar Naveed
doaj   +1 more source

Highly conserved regions in Ebola virus RNA dependent RNA polymerase may be act as a universal novel peptide vaccine target: a computational approach

open access: yesIn Silico Pharmacology, 2015
Ebola virus (EBOV) is such kind of virus which is responsible for 23,825 cases and 9675 deaths worldwide only in 2014 and with an average diseases fatality rate between 25 % and 90 %.
A. R. Oany   +4 more
semanticscholar   +1 more source

Comparison of high-performance thin layer chromatography/UV-densitometry and UV-derivative spectrophotometry for the determination of trimetazidine in pharmaceutical formulations

open access: yesActa Pharmaceutica, 2019
New methods for assaying trimetazidine dihydrochloride on the basis of thin layer chromatography and spectrophotometry are proposed and compared in the paper.
Gackowski Marcin   +3 more
doaj   +1 more source

Miniaturized shake-flask HPLC method for determination of distribution coefficient of drugs used in inflammatory bowel diseases

open access: yesActa Pharmaceutica, 2019
A new method for determination of distribution coefficient of drugs azathioprine, 6-mercaptopurine and 6-thioguanine and nutrient folic acid used in the treatment of inflammatory bowel disease based on a miniaturized shake-flask and HPLC/DAD was ...
Brusač Edvin   +3 more
doaj   +1 more source

Low Fidelity Mutants in the O-Helix of Thermus aquaticus DNA Polymerase I*

open access: yesJournal of Biological Chemistry, 1997
We screened 67 mutants in the O-helix of Thermus aquaticus (Taq) DNA polymerase I (pol I) for altered fidelity of DNA synthesis. These mutants were obtained (Suzuki, M., Baskin, D., Hood, L., and Loeb, L. A. (1996) Proc. Natl. Acad. Sci. U. S. A.
Motoshi Suzuki   +3 more
semanticscholar   +1 more source

Development of Novel Formulations to Enhance in Vivo Transdermal Permeation of Tocopherol

open access: yesActa Pharmaceutica, 2014
Tocopherol represents a big challenge for transdermal permeation owing to its extreme hydrophobicity and large molecular mass. The aim of the present study was to develop alpha-tocopherol (T) topical formulations and evaluate their ex vivo and in vivo ...
Nada Aly H.   +3 more
doaj   +1 more source

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