Results 91 to 100 of about 110,208 (302)

Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer

BMC Cancer, 2008
Background Enhanced activity of histone deacetylases (HDAC) is associated with more aggressive tumour behaviour and tumour progression in various solid tumours.
Jung Klaus, Stephan Carsten, Beckers Thomas, Gekeler Volker, Röske Annika, Weichert Wilko, Fritzsche Florian R, Scholman Katharina, Denkert Carsten, Dietel Manfred, Kristiansen Glen   +10 more
doaj   +1 more source

Epigenetics and chromatin remodeling play a role in lung disease [PDF]

, 2011
Epigenetics is defined as heritable changes that affect gene expression without altering the DNA sequence. Epigenetic regulation of gene expression is facilitated through different mechanisms such as DNA methylation, histone modifications and RNA ...
Adcock, IM, Barnes, PJ, Masjedi, MR, Mortaz, E   +3 more
core   +1 more source

Heat shock induces rapid resorption of primary cilia [PDF]

, 2012
Primary cilia are involved in important developmental and disease pathways, such as the regulation of neurogenesis and tumorigenesis. They function as sensory antennae and are essential in the regulation of key extracellular signalling systems.
Anckar, Baker, Berbari, Boyault, Breunig, Caspary, Corbit, Cotto, Davenport, Fliegauf, Gherman, Han, Haycraft, Kültz, Lange, McGlashan, Meimaridou, Nauli, Ng, Nigg, Overgaard, Pedersen, Pugacheva, Quarmby, Rohatgi, Rosenbaum, Schneider, Seeley, Singla, Taipale, Takaki, Weis, Williams   +32 more
core   +1 more source

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Advanced Science, EarlyView.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia, Ying Cui, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Bing Qin, Xintong Cai, Jie Wang, Jing Huang, Scott B. Rothbart, Zufeng Guo, Stephen B. Baylin, Xiangqian Kong   +15 more
wiley   +1 more source

Internuclear gene silencing in Phytophthora infestans is established through chromatin remodelling [PDF]

, 2008
In the plant pathogen Phytophthora infestans, nuclear integration of inf1 transgenic DNA sequences results in internuclear gene silencing of inf1. Although silencing is regulated at the transcriptional level, it also affects transcription from other ...
Appiah, A.A., Govers, F., Gow, N.A.R., Grenville-Briggs, L., Li, S., Shepherd, S.J., Walker, C.A., West, P., van   +7 more
core   +3 more sources

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Checkpoint Blockade Rescues the Repressive Effect of Histone Deacetylases Inhibitors on γδ T Cell Function

Frontiers in Immunology, 2018
Histone deacetylases (HDAC) are one of the key epigenetic modifiers that control chromatin accessibility and gene expression. Their role in tumorigenesis is well established and HDAC inhibitors have emerged as an effective treatment modality.
Sajad A. Bhat, Sajad A. Bhat, Disha Mohan Vedpathak, Disha Mohan Vedpathak, Shubhada V. Chiplunkar, Shubhada V. Chiplunkar   +5 more
doaj   +1 more source

Synthesis of hybrid anticancer agents based on kinase and histone deacetylase inhibitors [PDF]

, 2014
Fragments based on the VEGFR2i Semaxanib (SU5416, (vascular endothelial growth factor receptor-2 inhibitor) and the HDACi (histone deacetylase inhibitor) SAHA (suberanilohydroxamic acid) have been merged to form a range of low molecular weight dual ...
Bradner, James E, Chuckowree, Irina, Coxhead, Peter, Guille, Matthew, Librizzi, Mariangela, Paranal, Ronald M, Patel, Hiren, Spencer, John, Wang, Minghua, Williams, Robin S B, Zuckermann, Alexandra   +10 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

HDAC2, HDAC4, HDAC5, HDAC7, HDAC8, HDAC9 Gen İfade Seviyelerinin Çocukluk Çağı Akut Lösemilerinde Prognoz İle İlişkisi

Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi, 2018
Amaç: Histon deasetilazların değişmiş ifadesi hematolojikmaligniteler için kanser tedavisinde hedef olabilecek niteliktedir. HDACmutasyonları ve anormal ifade seviyeleri çeşitli kanser tiplerinde ve özelliklehematolojik malignitelerde sıklıkla görülmekte
Dilara Akın Balı, Ahmet Emin Kürekçi, Mehmet Nejat Akar   +2 more
doaj   +1 more source