Results 81 to 90 of about 110,208 (302)
Advanced Science, EarlyView.Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley +1 more source
Histone deacetylase activity is decreased in peripheral blood monocytes in patients with COPD
Journal of Inflammation, 2012 Background Histone deacetylase (HDAC) is an enzyme that regulates chromatin structure and inflammatory gene expression. In patients with chronic obstructive pulmonary disease (COPD), while accumulating evidence indicates that the activity of HDAC is ...
Chen Yanwei +6 more
doaj +1 more source
Coordinated actions of microRNAs with other epigenetic factors regulate skeletal muscle development and adaptation [PDF]
, 2017 Epigenetics plays a pivotal role in regulating gene expression in development, in response to cellular stress or in disease states, in virtually all cell types.
Adamo, Sergio +3 more
core +1 more source
Advanced Science, EarlyView.Prolonged exposure to stiff extracellular matrix drives cancer‐associated fibroblasts into a persistently activated myofibroblast state. Two parallel pathways are identified: β1 integrin activation smoothens the nuclear lamina to reduce lamin–chromatin contacts, while the formin mDia2 regulates nuclear actin to alter chromatin organization.
Swathi Packirisamy +4 more
wiley +1 more source
Cancer Management and Research, 2020 Mahan Mohammadi,1 Shiva Irani,1 Iman Salahshourifar,1 Jalil Hosseini,2 Afshin Moradi,3 Farkhondeh Pouresmaeili2,4 1Department of Molecular Genetics, Faculty of Science, Science and Research Branch, Islamic Azad University, Tehran, Iran; 2Men’s ...
Mohammadi M +5 more
doaj
Pharmaceuticals, 2014 Histone deacetylases (HDACs) enzymes, which affect the acetylation status of histones and other important cellular proteins, have been recognized as potentially useful therapeutic targets for a broad range of human disorders.
Elizabeth A. Thomas
doaj +1 more source
Retinoblastoma makes its mark on imprinting in plants [PDF]
, 2008 Genomic imprinting results in the preferential expression of alleles from either the maternal or paternal chromosomes. This epigenetic process occurs in embryonic and extra-embryonic (placental) tissues of mammals, but only in the extra-embryonic ...
Liliana M Costa +29 more
core +2 more sources
Advanced Science, EarlyView.Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang +10 more
wiley +1 more source
With NuRD, HDACs Go “Nerdy” [PDF]
Developmental Cell, 2014 Reporting in a recent issue of Neuron, Yamada et al. (2014) show that the histone deacetylase (HDAC)-containing NuRD complex plays a critical role in shutting down expression of specific synaptogenesis-related genes in the cerebellum, resulting in enhanced differentiation of presynaptic structures.
Sun, Yi Eve, Cheng, Liming, Hu, Keping
openaire +2 more sources
Advanced Science, EarlyView.The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan +16 more
wiley +1 more source