Results 131 to 140 of about 116,207 (325)

NEDD8 and HDACs: promising cotargets in AML [PDF]

, 2016
Kapil N. Bhalla, Warren Fiskus
openalex   +1 more source

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, EarlyView.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer

iMetaMed, EarlyView.
The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang, Ke Zhang, Lijie Xia, Jinyao Li   +3 more
wiley   +1 more source

Identification of histone deacetylase inhibitors as neutrophil recruitment modulators in zebrafish using a chemical library screen

Disease Models & Mechanisms, 2023
Sijia Fan, Jinlong Jiang, Huan Zhang, Cuihong Wang, Shang Kong, Tingting Zhao, Ling Meng, Yang Liu, Jingjing Qin, Xiuqin Rong, Zhenting He, Qinke He, Ke He, Ketong Chen, Ling Lei, Xinyu Hai, Hong Nie, Chunguang Ren   +17 more
doaj   +1 more source

HDAC inhibitor‐based therapies: Can we interpret the code? [PDF]

, 2012
Maria I. New, Heidi Olzscha, Nicholas B. La Thangue   +2 more
openalex   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Cisplatin-enriching cancer stem cells confer multidrug resistance in non-small cell lung cancer via enhancing TRIB1/HDAC activity [PDF]

, 2017
Lihui Wang, Xing Liu, Yong Ren, Jingyuan Zhang, Junli Chen, Wenlong Zhou, Wei Guo, Xiaoxuan Wang, Huiping Chen, Meng Li, Xiangzhong Yuan, Xun Zhang, Jingyu Yang, Chunfu Wu   +13 more
openalex   +1 more source

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source

Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents

Biologics: Targets & Therapy, 2013
Katherine Ververis,1 Alison Hiong,1 Tom C Karagiannis,1,* Paul V Licciardi2,*1Epigenomic Medicine, Alfred Medical Research and Education Precinct, 2Allergy and Immune Disorders, Murdoch Childrens Research Institute, Melbourne, VIC, Australia*These ...
Ververis K, Hiong A, Karagiannis TC, Licciardi PV   +3 more
doaj  

Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition [PDF]

, 2013
José P. López‐Atalaya, Satomi Ito, Luis M. Valor, Eva Benito, Ángel Barco   +4 more
openalex   +1 more source