Results 171 to 180 of about 116,207 (325)

Compound Library Screening Identified Cladribine as a Novel Radiosensitizer for Prostate Cancer

Cancer Science, EarlyView.
The combination of cladribine and irradiation significantly suppressed the growth of DU145‐derived tumors compared with the DMSO plus irradiation group in the mouse model. In addition, it also elevated the percentage of γH2AX‐positive cells after irradiation.
Toshiki Oka, Koji Hatano, Shohei Katsuki, Tomohiro Kanaki, Shunsuke Inoguchi, Masaru Tani, Akihiro Yoshimura, Yuki Horibe, Yutong Liu, Nesrine Sassi, Yohei Okuda, Akinaru Yamamoto, Toshihiro Uemura, Gaku Yamamichi, Yu Ishizuya, Takuji Hayashi, Yoshiyuki Yamamoto, Taigo Kato, Atsunari Kawashima, Keisuke Tamari, Bangzhong Lin, Akiyoshi Tani, Kazutake Tsujikawa, Yutaka Takahashi, Kazuhiko Ogawa, Shawn E. Lupold, Norio Nonomura   +26 more
wiley   +1 more source

Epigenome Modifying Tools In Asthma [PDF]

, 2015
Adcock,, Brook, PO, Durham, AL, Perry, M
core   +1 more source

Endocrine Resistance Score Based on Three Key Genes Predicts Prognosis and Reveals Potential Therapeutic Targets for ER+HER2− Breast Cancer

Cell Proliferation, EarlyView.
We generated endocrine‐resistant BC cell lines and identified CLEC3A, PCDH10, and ST3GAL1 as key endocrine‐resistant genes. More importantly, we validated their role in mediating resistance through PI3K‐AKT signalling and developed a predictive ERS with strong clinical relevance.
Liqin Ping, Lewei Zhu, Nian Chen, Xikun Liu, Jirui Zhong, Xiaoqing Sun, Hailin Tang, Kaiming Zhang   +7 more
wiley   +1 more source

Histone deacetylase 1 (HDAC‐1) required for the normal formation of craniofacial cartilage and pectoral fins of the zebrafish [PDF]

, 2004
Renjitha Pillai, Louise E. Coverdale, Gaytri Dubey, Christian Martin   +3 more
openalex   +1 more source

Selective targeting of cortactin tandem repeat acetylation by human lysine deacetylases

The FEBS Journal, EarlyView.
Cortactin function is regulated by acetylation at several lysine residues within its tandem repeat region. Using genetic code expansion to generate cortactin variants containing precisely defined acetylation marks, we show that HDAC6 is the primary enzyme removing these modifications, with SIRT1 and SIRT2 also acting at selected sites but with lower ...
Jan Komarek, Miroslava Vosahlikova, Zsofia Kutil, Zora Novakova, Julia Kudlacova, Ruzena Tuckova, Marat Meleshin, Barbora Havlinova, Pavlina Jaklova, Jana Ptackova, Cordelia Schiene‐Fischer, Mike Schutkowski, Cyril Barinka   +12 more
wiley   +1 more source

Plasticity of gene expression in the nervous system by exposure to environmental odorants that inhibit HDACs

, 2023
Sachiko Haga‐Yamanaka, Rogelio Nunez-Flores, Christi Ann Scott, Sarah Perry, Stephanie Turner Chen, Crystal Pontrello, Meera G. Nair, Anandasankar Ray   +7 more
openalex   +1 more source

Epigenetic Regulation in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
The aim of this narrative literature review was to identify epigenetic marks associated with periodontitis and to place them in a biological context. The literature was reviewed based on pre‐defined criteria. Cell type specific chromatin and mRNA modifications were included.
Henrik Dommisch, Arne Sönke Schäfer, Denica Kuzmanova, Dominique S. Michaud   +3 more
wiley   +1 more source

NF-κB Is a Potential Therapeutic Target for Histone Deacetylase Inhibitor-Resistant Cutaneous T-Cell Lymphoma. [PDF]

Cancer Sci
We identified a novel mechanism of resistance to histone deacetylase inhibitors (HDACi) in cutaneous T‐cell lymphoma (CTCL), mediated by NF‐κB activation. This finding highlights NF‐κB as a potential therapeutic target for overcoming HDACi resistance in CTCL.
Takahashi Y, Kitadate A, Iwama S, Kuroki W, Abe K, Yamada M, Ikeda S, Tagawa H, Wakui H, Hikida M, Takahashi N.   +10 more
europepmc   +2 more sources

Genome-wide Loss-of-Function Screen Reveals an Important Role for the Proteasome in HDAC Inhibitor-Induced Apoptosis [PDF]

, 2009
Susan Fotheringham, Mirjam T. Epping, Lindsay Stimson, Omar Khan, Victoria Wood, Francesco Pezzella, René Bernards, Nicholas B. La Thangue   +7 more
openalex   +1 more source

Supplemental Materials and Methods from Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth

, 2023
Rajneesh Pathania, Sabarish Ramachandran, G. Mariappan, Priyanka Thakur, Huidong Shi, Jeong-Hyeon Choi, Santhakumar Manicassamy, Ravindra Kolhe, Puttur D. Prasad, Suash Sharma, Bal L. Lokeshwar, Vadivel Ganapathy, Muthusamy Thangaraju   +12 more
openalex   +1 more source