MedComm, Volume 7, Issue 4, April 2026.Pancreatic cancer stem cells (CSCs) maintain stemness and tumorigenicity through NDUFS1‐mediated complex I activity, which is transcriptionally upregulated via the CD147‐STAT3 signaling axis. Enhanced oxidative phosphorylation (OXPHOS) and NAD+ production driven by this CD147‐NDUFS1 axis subsequently trigger the SIRT1‐DNMT1 metaboloepigenetic signaling
Xin‐Yu Fan +17 more
wiley +1 more source
Defining the heterogeneous molecular landscape of lung cancer cell responses to epigenetic inhibition. [PDF]
Commun BiolLin C +7 more
europepmc +1 more source
MedComm, Volume 7, Issue 4, April 2026.E1A is an important protein for adenovirus to initiate viral replication. Previous reports have shown that E1A binds to p300 as a regulatory factor. However, our study provides a new perspective that E1A promotes oncolytic adenovirus replication by degrading p300.
Boduan Xiao +7 more
wiley +1 more source
CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the treatment of Alzheimer's disease. [PDF]
Alzheimers Res TherLu W +14 more
europepmc +1 more source
Isocitrate Dehydrogenase‐Mutant Astrocytomas: Risk Stratification and Therapeutic Advance
MedComm, Volume 7, Issue 4, April 2026.This graphical abstract synthesizes the core logic of our revised review by linking integrated diagnosis, risk stratification, and trajectory‐based management in IDH‐mutant astrocytomas across CNS WHO Grades 2–4. It highlights lineage‐defining molecular classification (IDH mutation with core co‐alterations), integrated histomolecular grading, and key ...
Shepeng Wei +3 more
wiley +1 more source
Correction: Genome-wide identification of the cytochrome P450 superfamily in Trichoplusia ni and in-silico expression of resistance against HDAC inhibitors. [PDF]
Sci RepAhmad A +10 more
europepmc +1 more source
British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang +18 more
wiley +1 more source
RETRACTION: HDAC-Inhibitor (S)-8 Disrupts HDAC6-PP1 Complex Prompting A375 Melanoma Cell Growth Arrest and Apoptosis. [PDF]
J Cell Mol Medeuropepmc +1 more source
MIG-6 Regulates HDAC1-Mediated Angiogenesis and Tumorigenesis in PTEN-Deficient Endometrioid Endometrial Cancer. [PDF]
Mol Cancer ResNahar S +9 more
europepmc +1 more source
Integration of epigenetics into ecotoxicology: insights and fundamental research needs
Biological Reviews, Volume 101, Issue 2, Page 826-847, April 2026.ABSTRACT Epigenetics refers to heritable changes in genome function that occur without direct alterations to the DNA sequence. A multitude of environmental contaminants can influence the epigenetic marks of a genome. Changes of epigenetic marks including DNA methylation, histone modifications, and non‐coding RNAs can induce alterations at the gene ...
Albano Pinto +3 more
wiley +1 more source