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Polygonum cognatum Extract: Multitarget Anti-inflammatory, Antidiabetic, and Epigenetic Modulation Properties. [PDF]

ChemistryOpen
Karaman S, Budak Y, Bozdemir EA.
europepmc   +1 more source

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review). [PDF]

Oncol Rep
Suwanwong Y, Ploensil P.
europepmc   +1 more source

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Epigenetic modulation and understanding of HDAC inhibitors in cancer therapy.

Life Science, 2021
The role of genetic and epigenetic factors in tumor initiation and progression is well documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA methyl transferases.
M. J. Ramaiah, A. D. Tangutur, Rajasekhar Reddy Manyam   +2 more
semanticscholar   +1 more source

The application of PROTAC in HDAC.

European journal of medicinal chemistry, 2023
Inducing protein degradation by proteolysis targeting chimera (PROTAC) has provided great opportunities for scientific research and industrial applications. Histone deacetylase (HDAC)-PROTAC has been widely developed since the first report of its ability
Shaoting Chen, Yuxiang Zheng, Benji Liang, Yudong Yin, Jian Yao, Quande Wang, Yanghan Liu, N. Neamati   +7 more
semanticscholar   +1 more source

Thirty years of HDAC inhibitors: 2020 hindsight.

Journal of Medicinal Chemistry, 2020
It is now thirty years since the first report of a potent zinc-dependent histone deacetylase (HDAC) inhibitor appeared. Since then, five HDAC inhibitors have received regulatory approval for cancer chemotherapy, while many others are in clinical ...
Terence C. S. Ho, A. Chan, Arasu Ganesan
semanticscholar   +1 more source