Results 261 to 270 of about 116,207 (325)

Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition

, 2014
Stephanie M. Tortorella, Simon G. Royce, Paul V. Licciardi, Tom C. Karagiannis   +3 more
openalex   +1 more source

THOC1 complexes with SIN3A to regulate R-loops and promote glioblastoma progression. [PDF]

Neoplasia
Budhiraja S, Faisal UH, Baisiwala S, Chojak R, Koutah L, Drewes NB, Cho S, Kazi HA, Chen R, Perrault EN, Chen L, Park CH, O'Shea MC, Nandoliya K, Duffy JT, Lin P, Sonabend AM, Dmello CC, Ahmed AU.   +18 more
europepmc   +1 more source

Treatment‐Related and Immune‐Related Adverse Events Associated With Immune Checkpoint Inhibitor‐Based Combination Therapies for Breast Cancer: A Systematic Review and Meta‐Analysis

Thoracic Cancer, Volume 17, Issue 3, February 2026.
This systematic review and meta‐analysis (100 trials, 9192 patients) clarifies breast cancer ICI‐based combination toxicity hierarchies. ICI‐ADC has higher grade ≥ 3 TRAEs; ICI‐mTKI has the worst irAEs, while ICI‐PARPi/HER2‐targeted combinations present the lowest risks.
Yunwei Lu, Huan Li, Ke Li, Yiting Chen, Shu Wang   +4 more
wiley   +1 more source

Microbial short chain fatty acids: Effective histone deacetylase inhibitors in immune regulation (Review). [PDF]

Int J Mol Med
Wang J, Zhao Q, Zhang S, Liu J, Fan X, Han B, Hou Y, Ai X.   +7 more
europepmc   +1 more source

Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs

, 2013
Jennifer M. Guerra-Bubb, Albert A. Bowers, William Smith, Ronald M. Paranal, Guillermina Estiú, Olaf Wiest, James E. Bradner, Robert M. Williams   +7 more
openalex   +1 more source

Lifespan‐Extending Endogenous Metabolites

Aging Cell, Volume 25, Issue 2, February 2026.
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley   +1 more source

Histone deacetylase HDAC7 restricts CD8 + T cell tumor infiltration and limits immunotherapy sensitivity in bladder cancer: reversal by pinocembrin. [PDF]

J Exp Clin Cancer Res
Lv J, Li K, Zhou J, Yu R, Lu Q, Liu B.
europepmc   +1 more source

Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Aging

Aging Cell, Volume 25, Issue 2, February 2026.
Aging impairs cerebrovascular health by driving mitochondrial dysfunction, oxidative stress, endothelial failure, and neurovascular uncoupling, leading to BBB breakdown and cognitive decline. In contrast, time‐restricted feeding/eating counteracts these mechanisms by restoring mitochondrial function, activating adaptive nutrient‐sensing pathways ...
Madison Milan, Eva Troyano‐Rodriguez, Jennifer Ihuoma, Sharon Negri, Rakesh Rudraboina, Aleksandra Kosmider, Shantipriya Awasthi, Priya Balasubramanian, Shannon Conley, Andriy Yabluchanskiy, Anna Csiszar, Zoltan Ungvari, Rafael de Cabo, Stefano Tarantini   +13 more
wiley   +1 more source

The Diverse Effect of HDAC Inhibitors: Sodium Butyrate and Givinostat on Microglia Polarization After Hypoxia-Ischemia In Vitro. [PDF]

Int J Mol Sci
Ziabska K, Pawelec P, Stanaszek L, Ziemka-Nalecz M.   +3 more
europepmc   +1 more source

Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model

, 2011
Chiranjeevi Sandi, Ricardo Mouro Pinto, Sahar Al‐Mahdawi, Vahid Ezzatizadeh, Glenn Barnes, Steve Jones, James R. Rusche, Joel Gottesfeld, Mark A. Pook   +8 more
openalex   +1 more source