Results 91 to 100 of about 16,072,038 (292)

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

Proinflammatorikus HDL vizsgálata

, 2010
Hazánkban a kardiovaszkuláris megbetegedések sajnálatos módon előkelő helyen állnak a halálozási statisztikákban, amelyen belül is az érelmeszesedésnek kiemelt szerepe van. Az érelmeszesedés hátterében a koleszterinháztartás egyensúlyának eltolódása áll,
Lőrincz, Hajnalka
core  

Pengaruh Pemberian Ekstrak Air Tebu Hitam (saccharum officinarum l.) Terhadap Kadar High Densitylipoprotein(hdl) Serum Mencit (mus musculus) Yang Diinduksi Diet Tinggi Kolesterol [PDF]

, 2018
Hiperkolesterolemia adalah keadaan terjadinya peningkatan kadar kolesterol dalam darah. Peningkatan kadar kolesterol total dan penurunan kadar HDL merupakan faktor risiko terjadinya penyakit kardiovaskular dan metabolik.
Ana Fama, Mardhatilla
core  

Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

Lipids in Health and Disease, 2020
Background This study aims to investigate the association of lipid ratios with intracranial atherosclerotic stenosis (ICAS) in a Chinese population. Methods This cross-sectional study included 658 consecutive patients with ischemic stroke.
Wen-Song Yang, Rui Li, Yi-Qing Shen, Xing-Chen Wang, Qing-Jun Liu, Hai-Yang Wang, Qi Li, Guo-En Yao, Peng Xie   +8 more
doaj   +1 more source

Cholesterol Laundry of Cell Membrane and Fatty Liver by Detergent Liposomes to Improve Anti‐Cancer Drug Responsiveness of Patient Liver Tissues

Advanced Science, EarlyView.
Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim, Joo Kyung Noh, Sewoom Baek, Seung Eun Yu, Jueun Kim, Seongyo Lee, Youngji Oh, Dai Hoon Han, Seyong Chung, Hak‐Joon Sung   +9 more
wiley   +1 more source

Receiver operating characteristic (ROC) curves of TG/HDL-C, TG, and HDL-C for insulin resistance.

, 2016
The area under the ROC curve ± standard error (95% CI):TG/HDL-C: 0.70 ± 0.03(0.65–0.75); TG: 0.69 ± 0.03(0.64–0.74); HDL-C: 0.37 ± 0.03(0.31–0.42). Abbreviations: TG:triglyceride; HDL-C:high-density lipoprotein cholesterol; TG/HDL-C:triglyceride to high ...
Zeng.ai Chen (2626813), Yaomin Hu (2626807), Tingting Han (1437814), Yangxue Li (1678933), Xingxing Ren (2626810), Shuang Zheng (768179), Wei Liu (20030)   +6 more
core   +1 more source

Low LDL-C and High HDL-C Levels Are Associated with Elevated Serum Transaminases amongst Adults in the United States: A Cross-sectional Study [PDF]

, 2014
Background: Dyslipidemia, typically recognized as high serum triglyceride, high low-density lipoprotein cholesterol (LDL-C) or low high-density lipoprotein cholesterol (HDL-C) levels, are associated with nonalcoholic fatty liver disease (NAFLD). However,
Jiang, Zhenghui, Yusuke Tsugawa, Kenneth Mukamal (509754), Elliot Tapper (509755), Simon C Robson, Elliot Tapper, Zhenghui Gordon Jiang (509753), Simon C. Robson (301209), Kenneth Mukamal, Mukamal, Kenneth, Tsugawa, Yusuke, Robson, Simon, Jiang, Zhenghui Gordon, Tapper, Elliot, Robson, Simon C, Yusuke Tsugawa (509756), Zhenghui Gordon Jiang   +16 more
core   +1 more source

Liver and serum lipids in Wistar rats fed a novel structured lipid containing conjugated linoleic acid and conjugated linolenic acid

Grasas y Aceites, 2019
Conjugated linoleic acid (CLA) and conjugated linolenic acid (CLnA) have been known to have several health-promoting effects. The aim of this study was to introduce a novel structured lipid (SL) including both CLA and CLnA (cis9, trans11, cis13-18:3 ...
M. Shagholian, S. A.H. Goli, A. Shirvani, M. R. Agha-Ghazvini, S. Asgary   +4 more
doaj   +1 more source