Results 101 to 110 of about 20,906,376 (325)

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

THE RISK FACTORS ASSOCIATED WITH DIABETIC DYSLIPIDEMIA AND ANTHROPOMETRIC PARAMETERS LINKED WITH AND WITHOUT DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS

Pakistan Armed Forces Medical Journal, 2020
Objective: To ascertain and identify risk determinants linked with and without dyslipidemia in type 2 diabetic patients. Study Design: Comparative cross-sectional study.
Zara Khalid Khan, Asifa Majeed, Amir Rashid   +2 more
doaj  

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

An Optimized Freeze‐Dry Multimodal Workflow for Sequential Micro‐CT Imaging, Histology, and Molecular Profiling: A Use Case in Human Liver Fibrosis

Advanced Science, EarlyView.
Optimized freeze‐drying and eosin staining deliver artifact‐free micro‐CT images of liver tissue at near‐histological detail, then hand the same specimen back for sectioning, staining, and sequencing. Fibrotic volume distinguishes normal liver from cirrhosis, while preserved RNA reveals inflammatory gene upregulation—one biopsy, three dimensions, and a
Kristijan Skok, Laura Činč Ćurić, Jernej Vajda, Silvia Schauer, Martin Wagner, Rudolf Stauber, Carolin Lackner, Karl Kashofer, Markus Plass, Giovanny Rodriguez Blanco, Ian R. Wanless, Uroš Maver, Katrin Panzitt, Boštjan Vihar   +13 more
wiley   +1 more source

Association of the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio and concentrations of plasma lipids with high-density lipoprotein subclass distribution in the Chinese population

Lipids in Health and Disease, 2010
Background To evaluate the relationship between the low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio and HDL subclass distribution and to further examine and discuss the potential impact of LDL-C and HDL-C ...
Long Shiyin, Qin Yang, Liu Yinghui, Tian Li, Xu Yanhua, Fu Mingde   +5 more
doaj   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Comorbidities of Obesity in a Rural African Population Residing in Limpopo Province, South Africa: A Comparison between General and Central Obesity

Obesities
Obesity is a growing epidemic that threatens to deplete healthcare resources by increasing the prevalence of diabetes, heart disease, high blood pressure, cancer, and chronic kidney disease.
Cairo B. Ntimana, Reneilwe G. Mashaba, Kagiso P. Seakamela, Eric Maimela, Matshane L. Masemola-Maphutha, Solomon S. R. Choma   +5 more
doaj   +1 more source

Saturated fat intake interacts with HDL‐c genes to influence plasma HDL‐c of Filipino women

The FASEB Journal, 2012
Low HDL‐c is highly prevalent among Asian populations. We aimed to determine whether a HDL‐c gene score interacts with dietary intake of saturated fat, non‐saturated fat, and carbohydrates to influence fasting HDL‐c levels in Filipino women participating in the 2005 Cebu Longitudinal Health and Nutrition Survey (
Niha Zubair, Linda Adair, Alan Feranil
openaire   +1 more source

Proinflammatorikus HDL vizsgálata

, 2010
Hazánkban a kardiovaszkuláris megbetegedések sajnálatos módon előkelő helyen állnak a halálozási statisztikákban, amelyen belül is az érelmeszesedésnek kiemelt szerepe van. Az érelmeszesedés hátterében a koleszterinháztartás egyensúlyának eltolódása áll,
Lőrincz, Hajnalka
core