Results 111 to 120 of about 20,906,376 (325)

Beyond Biomimetics: Pathology‐Informed Engineering Rescues Reconstituted HDL From Inflammatory Dysfunction for Sepsis Immunotherapy

Advanced Science, EarlyView.
A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou, Lei Zhang, Xingyu Cai, Jiajia Su, Guangyu Dai, Xue Chen, Hanming Wang, Jia Hua, Jianping Liu, Chunmeng Sun, Xiancheng Chen, Erhao Wang, Wenli Zhang   +12 more
wiley   +1 more source

Role of the SAFE pathway and the mitochondria in HDL cholesterol (and its constituent sphingosine-1-phosphate) induced cardioprotection [PDF]

, 2011
High density lipoprotein cholesterol (HDL) and its component sphingosine-1-phosphate (S1P) protect against myocardial infarction. Recently, the SAFE (survivor activating factor enhancement) pathway, involving tumour necrosis factor (TNF) and the ...
Hacking, Damian
core   +1 more source

Liver and serum lipids in Wistar rats fed a novel structured lipid containing conjugated linoleic acid and conjugated linolenic acid

Grasas y Aceites, 2019
Conjugated linoleic acid (CLA) and conjugated linolenic acid (CLnA) have been known to have several health-promoting effects. The aim of this study was to introduce a novel structured lipid (SL) including both CLA and CLnA (cis9, trans11, cis13-18:3 ...
M. Shagholian, S. A.H. Goli, A. Shirvani, M. R. Agha-Ghazvini, S. Asgary   +4 more
doaj   +1 more source

Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

Lipids in Health and Disease, 2020
Background This study aims to investigate the association of lipid ratios with intracranial atherosclerotic stenosis (ICAS) in a Chinese population. Methods This cross-sectional study included 658 consecutive patients with ischemic stroke.
Wen-Song Yang, Rui Li, Yi-Qing Shen, Xing-Chen Wang, Qing-Jun Liu, Hai-Yang Wang, Qi Li, Guo-En Yao, Peng Xie   +8 more
doaj   +1 more source

Intravenous sphingosylphosphorylcholine protects ischemic and postischemic myocardial tissue in a mouse model of myocardial ischemia/reperfusion injury [PDF]

, 2010
HDL, through sphingosine-1-phosphate (S1P), exerts direct cardioprotective effects on ischemic myocardium. It remains unclear whether other HDL-associated sphingophospholipids have similar effects.
Bodo Levkau, Levkau, Bodo, Herrgott, Ilka, Johanning, Kai, Echtermeyer, Frank, Chun, Jerold, Hildebrand, Reinhard, Ilka Herrgott, Gregor Theilmeier, Christine Herzog, Winterhalter, Michael, Frank Ulrich Müller, Schmitz, Martina, Müller, Frank Ulrich, Jan Mersmann, Michael Winterhalter, Reinhard Hildebrand, Martina Schmitz, Herzog, Christine, Frank Echtermeyer, Jerold Chun, Theilmeier, Gregor, Mersmann, Jan, Larmann, Jan, Jan Larmann, Kai Johanning   +25 more
core   +1 more source

Beyond Probiotics: Postbiotics for Healthy Aquaculture

Advanced Science, EarlyView.
This critical review assesses limitations of probiotics and proposes postbiotics, preparations of inanimate microorganisms and their metabolites, as a more stable, controlled, and biosafe formulation. Postbiotics offer significant advantages during industrial aquafeed production and storage. However, their practical implementation is currently hindered
Michael Leonidas Chikindas, Delin Xu, Igor V. Popov, Kayque Ordonho Carneiro, Nilufar Arashovna Elova, Gullola Amirovna Bekmurodova, Dildora Amindjanovna Amirsaidova, Astghik Pepoyan, Shakhlo Mirjamalovna Miralimova, Oleg V. Mitrokhin, Liubov S. Sichel, John Tagg, Svetoslav Dimitrov Todorov   +12 more
wiley   +1 more source

Receiver operating characteristic (ROC) curves of TG/HDL-C, TG, and HDL-C for insulin resistance.

, 2016
The area under the ROC curve ± standard error (95% CI):TG/HDL-C: 0.70 ± 0.03(0.65–0.75); TG: 0.69 ± 0.03(0.64–0.74); HDL-C: 0.37 ± 0.03(0.31–0.42). Abbreviations: TG:triglyceride; HDL-C:high-density lipoprotein cholesterol; TG/HDL-C:triglyceride to high ...
Zeng.ai Chen (2626813), Yaomin Hu (2626807), Tingting Han (1437814), Yangxue Li (1678933), Xingxing Ren (2626810), Shuang Zheng (768179), Wei Liu (20030)   +6 more
core   +1 more source

Developmental Environmental Chronotoxicity by Polystyrene Nanoplastics Exacerbates High‐Fat Diet‐Induced Pediatric MAFLD Through Circadian Disruption and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Polystyrene nanoplastics exacerbate high‐fat diet‐induced metabolic dysfunction in an age‐dependent manner. Juvenile mice exhibit greater susceptibility, characterized by circadian disruption, impaired mitochondrial function, reduced energy metabolism, and enhanced hepatic lipid accumulation.
Peihao Xu, Shuting Huang, Leilei Zhu, Junyi Huang, Kewei Li, Guangming Li, Jiannong Wu, Mingyuan Zhou, Fangmei Zhou, Zhishan Ding, Yingzhi Shen   +10 more
wiley   +1 more source

The mediation effect of HDL-C: Non-HDL-C on the association between inflammatory score and recurrent coronary events

Heliyon
Inflammation and lipids are both involved in the pathogenesis of coronary heart disease (CHD). However, the mediation effect of lipoproteins on the association between inflammation and recurrent coronary events in CHD patients remains unclear.This was a retrospective study including CHD patients hospitalized in the Department of Cardiovascular Medicine
Jie Zhang, Hongwei Li, Runlu Sun, Zhengyu Cao, Jingjing Huang, Yuan Jiang, Mingxing Mo, Lingyu Luo, Qi Guo, Qian Chen, Yuling Zhang   +10 more
openaire   +3 more sources

Evaluation of triglyceride: HDL-C ratio and Non-HDL-C as harbingers of increased cardiovascular risk in metabolic syndrome [PDF]

, 2016
Background: Metabolic syndrome is an aggregate of conditions that together increases the risk of developing cardiovascular disease and type 2 diabetes mellitus.
R., Dharuni, R., Harish, H. L., Vishwanath, B. V., Maruthi Prasad   +3 more
core   +1 more source