Results 41 to 50 of about 682,721 (387)

HDL cholesterol efflux capacity and incident cardiovascular events.

New England Journal of Medicine, 2014
BACKGROUND It is unclear whether high-density lipoprotein (HDL) cholesterol concentration plays a causal role in atherosclerosis. A more important factor may be HDL cholesterol efflux capacity, the ability of HDL to accept cholesterol from macrophages ...
Anand Rohatgi, A. Khera, J. Berry, Edward G. Givens, C. Ayers, K. Wedin, I. Neeland, I. Yuhanna, Daniel Rader, J. D. de Lemos, P. Shaul   +10 more
semanticscholar   +1 more source

The triglyceride to high-density lipoprotein ratio identifies children who may be at risk of developing cardiometabolic disease [PDF]

, 2014
Aim: It is important to develop simple, reliable methods to identify high-risk individuals who may benefit from intervention. This study investigated the association between the triglyceride to high-density lipoprotein cholesterol (TG/HDL) ratio and ...
Baker, Berenson, Boddy, Bonito, Chen, Chu, Cole, Department for Communities and Local Government, Ekelund, Giannini, Hannon, Li, Mattocks, McCarthy, McLaughlin, Millan, National Cholesterol Education Panel, National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents, Nguyen, Olson, Parikh, Riddoch, Rowlands, Ruiz, Twisk, Urbina, Weiss, Yunke, Zimmet   +28 more
core   +1 more source

HDL endocytosis and resecretion

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2013
HDL removes excess cholesterol from peripheral tissues and delivers it to the liver and steroidogenic tissues via selective lipid uptake without catabolism of the HDL particle itself. In addition, endocytosis of HDL holo-particles has been debated for nearly 40years.
Herbert Stangl, Clemens Röhrl
openaire   +3 more sources

Anti-inflammatory and antioxidant properties of HDLs are impaired in type 2 diabetes. [PDF]

, 2011
ObjectiveIn mice, 4F, an apolipoprotein A-I mimetic peptide that restores HDL function, prevents diabetes-induced atherosclerosis. We sought to determine whether HDL function is impaired in type 2 diabetic (T2D) patients and whether 4F treatment improves
Boldrini, Beatrice, Ferrannini, Ele, Fogelman, Alan M, Imaizumi, Satoshi, Morgantini, Cecilia, Natali, Andrea, Navab, Mohamad, Reddy, Srinivasa T   +7 more
core   +1 more source

Effects of flavonoids on cholesterol efflux capability

International Journal of Medical Biochemistry, 2022
Reverse cholesterol transport (RCT), which plays a critical role in the export of cholesterol from peripheral cells, is one of the processes employed in the management and treatment of atherosclerosis.
Maha Abdulmajeed Ayoub
doaj   +1 more source

GALNT2 mRNA levels are associated with serum triglycerides in humans [PDF]

, 2016
Atherogenic dyslipidemia, characterized by high triglycerides (TG) and low high density lipoprotein (HDL)-cholesterol levels, is a feature of patients with insulin resistance, obesity, and type 2 diabetes (T2D) [1] and plays a major role in shaping the ...
Di Paola, Rosa, Mangiacotti, Davide, Marucci, Antonella, TRISCHITTA, VINCENZO   +3 more
core   +1 more source

Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques.

Arteriosclerosis, Thrombosis and Vascular Biology, 2019
OBJECTIVE HDL (high-density lipoprotein) infusion reduces atherosclerosis in animal models and is being evaluated as a treatment in humans. Studies have shown either anti- or proinflammatory effects of HDL in macrophages, and there is no consensus on the
Panagiotis Fotakis, V. Kothari, D. G. Thomas, M. Westerterp, M. Molusky, E. Altin, Sandra Abramowicz, Nan Wang, Yi He, J. Heinecke, K. Bornfeldt, A. Tall   +11 more
semanticscholar   +1 more source

Causal relevance of blood lipid fractions in the development of carotid atherosclerosis: Mendelian randomization analysis. [PDF]

, 2013
BACKGROUND: Carotid intima-media thickness (CIMT), a subclinical measure of atherosclerosis, is associated with risk of coronary heart disease events. Statins reduce progression of CIMT and coronary heart disease risk in proportion to the reduction in ...
Baldassarre, Damiano, Casas, Juan-Pablo, de Faire, Ulf, Deanfield, John, Drenos, Fotios, Gertow, Karl, Gigante, Bruna, Hamsten, Anders, Hingorani, Aroon D, Holmes, Michael V, Humphries, Steve E, Kivimaki, Mika, Kumari, Meena, Langenberg, Claudia, Sennblad, Bengt, Shah, Sonia, Strawbridge, Rona J, Swerdlow, Daniel I, Talmud, Philippa J, Tremoli, Elena, Veglia, Fabrizio, Wareham, Nick, Whittaker, John   +22 more
core   +1 more source

Extract from Silybum marianum as a nutraceutical: a double-blind placebo-controlled study in healthy young men

Czech Journal of Food Sciences, 2001
In a randomized, double-blind, placebo-controlled study, the effect of an extract from Silybum marianum seeds (ESM, milk thistle extract) on lipid and liver parameters and the antioxidant capacity of serum was investigated in 29 healthy men aged 18-32 ...
V. Šimánek, N. Škottová, J. Bartek, J. Psotová, P. Kosina, L. Balejová, J. Ulrichová   +6 more
doaj   +1 more source

THE EFFECTIVENESS OF ETHANOL EXTRACT OF JAMBLANG LEAVES (Syzygium cumini L.) IN INCREASING HDL LEVELS IN WISTAR RATS MODELS OF METABOLIC SYNDROME

Jurnal Riset Kesehatan, 2023
One of the characteristics of metabolic syndrome (MetS) is the low high-density lipoprotein (HDL) levels. Jamblang leaves (Syzygium cumini L.) contain various phytochemicals, which have antihyperglycemic, antihyperlipidemic, and antioxidant properties ...
Muthmainah Muthmainah, Ida Nurwati, Selfi Handayani, Dyonisa Nasirochmi Pakha   +3 more
doaj   +1 more source