Results 41 to 50 of about 2,675,526 (303)

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

CIGB-258, a Potential Novel Approach to Treat Sepsis-like Hyperinflammation, Reduces Gastrointestinal Hemorrhage in Zebrafish Exposed to Carboxymethyllysine and Ethanol

Pharmaceuticals
Objective: CIGB-258 is a 3 KDa altered peptide ligand recognized for its anti-inflammatory activity. Herein, the effect of CIGB-258 was assessed against carboxymethyllysine (CML) and ethanol (Et-OH)-induced sepsis-like events in zebrafish (Danio rerio ...
Kyung-Hyun Cho, Yunki Lee, Sang Hyuk Lee, Ashutosh Bahuguna, María del Carmen Domínguez-Horta, Gillian Martínez-Donato   +5 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Correlation between Serum Caspase-1, IL-10, HOMA-IR, FAI, Dyslipidemia, and Oxidative Stress Status in Women with Polycystic Ovary Syndrome

Journal of Pharmacy and Bioallied Sciences
Introduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy characterized by hyperandrogenism, insulin resistance, and dyslipidemia. Inflammation and oxidative stress play critical roles in its pathogenesis.
Neelam Gusain, Ashish Anjankar, Ranjit Ambad   +2 more
doaj   +1 more source

Effects of flavonoids on cholesterol efflux capability

International Journal of Medical Biochemistry, 2022
Reverse cholesterol transport (RCT), which plays a critical role in the export of cholesterol from peripheral cells, is one of the processes employed in the management and treatment of atherosclerosis.
Maha Abdulmajeed Ayoub
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

HDL Subclass Proteomic Analysis and Functional Implication of Protein Dynamic Change During HDL Maturation [PDF]

, 2019
Recent clinical trials reported that increasing high-density lipoprotein-cholesterol (HDL-C) levels does not improve cardiovascular outcomes. We hypothesize that HDL proteome dynamics determine HDL cardioprotective functions.
Gordon, Scott M., Saredy, Jason, Yang, Xiaofeng, Paz, Merlin Abner, Remaley, Alan Thomas, Xi, Hang, Yang, William, Zhang, Yuling, Sun, Runlu, Khan, Mohsin, Choi, Seungbum, Wang, Hong, Wang, Jing-Feng   +12 more
core   +1 more source

Systemic Extracerebral Atherosclerotic Burden and Dementia Risk After Incident Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Stroke survivors are at increased risk of dementia, but clinically accessible markers of risk heterogeneity remain limited. Previous studies have largely examined atherosclerotic disease in individual vascular beds rather than the overall burden of systemic extracerebral atherosclerosis.
Zhexuan Yu, Tianxue Chen, Wei Jin, Weifeng Jin, Haitong Wan   +4 more
wiley   +1 more source

Effect of Addition of Methionine to Rice Protein on the Cholesterol and Lipoproteins Concentrations in Rats [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2012
The effect of the addition of methionine to rice protein on the levels of plasma and lipoproteins cholesterol in relation to the casein were investigated in rats.
Jaefar Dhahir, Jaber Dhahir, Qassem Al-Awwad   +2 more
doaj   +1 more source