Results 31 to 40 of about 933,327 (380)

Causal relevance of blood lipid fractions in the development of carotid atherosclerosis: Mendelian randomization analysis. [PDF]

open access: yes, 2013
BACKGROUND: Carotid intima-media thickness (CIMT), a subclinical measure of atherosclerosis, is associated with risk of coronary heart disease events. Statins reduce progression of CIMT and coronary heart disease risk in proportion to the reduction in ...
Baldassarre, Damiano   +22 more
core   +1 more source

Selective delipidation of plasma HDL enhances reverse cholesterol transport in vivo

open access: yesJournal of Lipid Research, 2009
Uptake of cholesterol from peripheral cells by nascent small HDL circulating in plasma is necessary to prevent atherosclerosis. This process, termed reverse cholesterol transport, produces larger cholesterol-rich HDL that transfers its cholesterol to the
Frank M. Sacks   +13 more
doaj   +1 more source

The Plasma Distribution of Non-cholesterol Sterol Precursors and Products of Cholesterol Synthesis and Phytosterols Depend on HDL Concentration

open access: yesFrontiers in Nutrition, 2022
Non-cholesterol sterols are transported in plasma lipoproteins and are consequently important in cholesterol metabolism. We investigated the distribution of non-cholesterol sterol precursors of cholesterol synthesis (NCSPCS), oxysterols, and phytosterols
Valéria Sutti Nunes   +8 more
doaj   +1 more source

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles. [PDF]

open access: yes, 2017
Treatment of dyslipidemia patients with lipid-lowering drugs leads to a significant reduction in low-density lipoproteins (LDL) level and a low to moderate level of increase in high-density lipoprotein (HDL) cholesterol in plasma.
Alderete, Benjamin   +7 more
core   +1 more source

Hepatic lipase stimulates the uptake of high density lipoprotein cholesterol by hepatoma cells.

open access: yesJournal of Lipid Research, 1983
The objective of this study was to determine whether high density lipoproteins (HDL) that have been treated with hepatic lipase have an enhanced ability to deliver cholesterol to cells.
M Bamberger, J M Glick, G H Rothblat
doaj   +1 more source

Effect of a novel nutraceutical combination on serum lipoprotein functional profile and circulating PCSK9 [PDF]

open access: yes, 2017
BACKGROUND: A beneficial effect on cardiovascular risk may be obtained by improving lipid-related serum lipoprotein functions such as high-density lipoproteins (HDLs) cholesterol efflux capacity (CEC) and serum cholesterol loading capacity (CLC) and by ...
Adorni, Maria Pia   +7 more
core   +3 more sources

National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries.

open access: yesInternational Journal of Epidemiology, 2019
BACKGROUND Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC).
C. Taddei   +360 more
semanticscholar   +1 more source

Cholesterol efflux via HDL resecretion occurs when cholesterol transport out of the lysosome is impaireds⃞

open access: yesJournal of Lipid Research, 2007
Recently, we showed that holo HDL particle uptake and resecretion occur in physiologically relevant cell lines and that HDL uptake is mediated by scavenger receptor class B type I (SR-BI).
Tamara A. Pagler   +4 more
doaj   +1 more source

Meta-regression analysis of the effects of dietary cholesterol intake on LDL and HDL cholesterol.

open access: yesAmerican Journal of Clinical Nutrition, 2018
Background Elevated low-density lipoprotein (LDL) cholesterol is a major risk factor for cardiovascular disease. Dietary guidance recommends reducing saturated fatty acid, trans fatty acid, and cholesterol intakes to reduce circulating LDL cholesterol ...
Melissa J. Vincent   +4 more
semanticscholar   +1 more source

Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease

open access: yesEuropean Journal of Preventive Cardiology, 2019
Background Low concentrations of high-density lipoprotein cholesterol (HDL-C) represent a well-established cardiovascular risk factor. Paradoxically, extremely high HDL-C levels are equally associated with elevated cardiovascular risk, resulting in the U-
Ma Feng   +24 more
semanticscholar   +1 more source

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