Results 71 to 80 of about 933,327 (380)

Redox‐Responsive Tellurium‐Bridged Covalent Organic Frameworks/PEG Composites for Targeted Therapy of Diabetic Cardiomyopathy

Advanced Science, EarlyView.
This study unlocks the immense potential of COF@polymer nanocomposites as a multifunctional therapeutic platform for targeted drug delivery in diabetic cardiomyopathy. Abstract Diabetic cardiomyopathy, a major complication of diabetes, is strongly associated with elevated levels of glycated hemoglobin (HbA1c) and reactive oxygen species (ROS). However,
Jing Xue, Jialu Zhuang, Taotao Fan, Songtao Tang, Junjun Wang, Xiaohui Liu, Jian Liu, Jin Shi, Jiaji Li, Wanjun Li, Danyou Hu, Xiaoqian Zhang, Hua Wang, Guiyang Zhang   +13 more
wiley   +1 more source

Triglyceride to high-density lipoprotein cholesterol and low-density lipoprotein cholestrol to high-density lipoprotein cholesterol ratios are predictors of cardiovascular risk in Iranian adults: Evidence from a population-based cross-sectional study

Caspian Journal of Internal Medicine, 2020
Background: The superiority of TG/HDL-C and LDL-C/HDL-C ratios in predicting  CVD risk is a matter of debates. Thus, the objective of this study was to compare TG/HDL-C and LDL-C to HDL-C ratios in predicting the risk of CVD events.
Karimollah Hajian-Tilaki, Behzad Heidari, Afsaneh Bakhtiari   +2 more
doaj  

Prevalence of High HDL Cholesterol and Its Associated Factors Among Tunisian Women of Childbearing Age: A Cross-Sectional Study [PDF]

, 2021
Fatma Ben Cherifa, Jalila El Ati, Radhouene Doggui, Myriam El Ati‐Hellal, Pierre Traissac   +4 more
openalex   +1 more source

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

Serum, but not monocyte macrophage foam cells derived from low HDL-C subjects, displays reduced cholesterol efflux capacity

Journal of Lipid Research, 2009
The main antiatherogenic function of HDL is to promote the efflux of cholesterol from peripheral cells and transport it to the liver for excretion in a process termed reverse cholesterol transport.
Shuhei Nakanishi, Riikka Vikstedt, Sanni Söderlund, Miriam Lee-Rueckert, Anne Hiukka, Christian Ehnholm, Mikko Muilu, Jari Metso, Jussi Naukkarinen, Leena Palotie, Petri T. Kovanen, Matti Jauhiainen, Marja-Riitta Taskinen   +12 more
doaj   +1 more source

Paradoxical mortality differential of HDL cholesterol

Asian Journal of Medical Sciences, 2023
High-density lipoprotein (HDL) cholesterol has been known for ages to be cardio-protective due to its defensive action against genesis of atherosclerosis.
Jyotishman Mukhopadhyay , Debayan Mallik , Sughandha Garg   +2 more
doaj   +1 more source

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population

Journal of Lipid Research, 2006
Zinc Finger Protein 202 (ZNF202) is a transcriptional repressor that binds elements found predominantly in genes involved in HDL metabolism. We tested the following hypotheses: 1) frequencies of single-nucleotide polymorphisms (SNPs) and haplotypes in ...
Maria C. Stene, Ruth Frikke-Schmidt, Børge G. Nordestgaard, Anne Tybjærg-Hansen   +3 more
doaj   +1 more source

Total cholesterol/HDL cholesterol ratio and monocyte/HDL cholesterol ratio are related with subclinical hypothyroidism in polycystic ovary syndrome

Türk Biyokimya Dergisi, 2021
There is an association between serum thyrotropin (TSH) and lipid profile. However, there is a little information regarding the relation between subclinical hypothyroidism (SCH), atherogenic indices and inflammation in polycystic ovary syndrome (PCOS ...
Cakir Isil, Simsek Yasin
doaj   +1 more source

Decrease of LDL Cholesterol Through The Increase of HDL Cholesterol by Administering Garcinia mangostana L. Peel Extract in White Mice

Folia Medica Indonesiana, 2021
Highlight: • Ethanol extract of Garcinia mangostana L. peel reduce malondialdehyde. • Garcinia mangostana L. peel extract can increase non-radical products which impact in decreasing LDL cholesterol and increasing HDL cholesterol.
Hasyim As'ari
doaj   +1 more source