Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics
The challenges of mRNA therapy and the application of artificial intelligence and gene editing in the field of mRNA drugs. ABSTRACT Artificial intelligence (AI) and gene editing are increasingly being applied to the design and evaluation of mRNA therapeutics.
Haixing Shi +11 more
wiley +1 more source
Prostate Cancer Development, Progression, and Therapy
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin +9 more
wiley +1 more source
Patient-specific 3D-printed HDR surface brachytherapy for basal cell carcinoma in older patients: prospective feasibility and imaging response. [PDF]
Sobolewski P +7 more
europepmc +1 more source
Robust optimization of catheter positions and dwell times for HDR prostate brachytherapy
Abstract Background HDR prostate brachytherapy plans are sensitive to catheter placement uncertainty, as discrepancies between planned and delivered catheter positions can degrade target coverage and increase organ at risk dose. Current inverse planning methods optimize dwell times for a fixed implant geometry and do not account for geometric ...
Joseph B. Schulz +3 more
wiley +1 more source
High dynamic range shortwave infrared imaging of mice with an InGaAs camera. [PDF]
Patel A +4 more
europepmc +1 more source
A TETRA‐primer amplification refractory mutation system polymerase chain reaction (T‐ARMS‐PCR) method was developed for simultaneous detection of the L412F/V and G408V mutations. L412F/V mutants were created using the CRISPR/Cas tool and no fitness cost was observed.
Georgios Sofianos +3 more
wiley +1 more source
Design of a High Dynamic Range Acquisition System for Airborne VNIR Push-Broom Hyperspectral Camera. [PDF]
Feng H, Wang Y, He D, Zhang C, Li C.
europepmc +1 more source
Technologies for engineering repetitive DNA
Abstract Repetitive DNA, a fundamental architectural element of genomes, is widespread across organisms and comprises about 54% of the human genome. With advances in long‐read sequencing and bioinformatics approaches, highly repetitive sequences can now be characterized in depth.
Shuting Ma, Yali Cui, Yi Wu
wiley +1 more source
Polish Brachytherapy Society clinical recommendations and expert consensus on radical high-dose-rate brachytherapy for prostate cancer. [PDF]
Chyrek AJ +24 more
europepmc +1 more source

