Results 51 to 60 of about 30,786 (257)

Handwritten digit recognition: Comparative analysis of ML, CNN, vision transformer, and hybrid models on the MNIST dataset

Journal of Intelligent Systems
Handwritten digit recognition (HDR) remains challenging due to variations in writing styles. To address this challenge, this study comprehensively compares ML (ML) and deep learning (DL) models. We explored a variety of approaches.
Ben Noureddine Dhouha
doaj   +1 more source

Parentesco silenciado. Luis XIV y los Austrias mayores

Cuadernos de Historia Moderna, 2014
El objetivo de este artículo es mostrar el puesto que los Austrias mayores ocuparon en la educación y en el discurso de grandeza de Luis XIV, descendiente directo por parte de madre, Ana de Austria, y ligado a la familia habsbúrgica de Viena por su ...
Sylvène Édouard
doaj   +1 more source

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, EarlyView.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

Embedding the public voice in clinical trials: developing public-informed training for patient data research

Research Involvement and Engagement
Background The use of health systems data (HSD) such as patient records and prescriptions is expanding within clinical trials to improve efficiency, reduce participant burden, and enhance real‑world relevance. However, challenges remain around governance,
Fiona V Lugg-Widger, Caroline Brocklehurst, Sarah Chave, Linda Farey, Araya Gautam, Edward Goodall, Michelle Abhayawardena Goonasekera, Daniel Iheanacho, Rashmi Kumar, Joanne Lloyd, Isla Mackenzie, Marion Mafham, Clara Martins de Barros, Elizabeth McCall, Stephen T Moore, Kim Munnery, Macey Murray, Nicholas Pitt, Yasmin Rahman, Sarah Rawlinson, Michael Robling, Amy Rogers, Kamil Sterniczuk, Robert Trubey   +23 more
doaj   +1 more source

Réparer la nature, est-ce bien raisonnable ? [PDF]

Sciences, Eaux & Territoires, 2017
Un problème se pose au gestionnaire qui souhaite préserver ou réhabiliter une zone humide : quel état de cette zone en perpétuelle évolution choisir ? Ce parti pris n’est pas anodin : il implique des notions de mémoire, d’héritage, de patrimoine.
DEREX, Jean-Michel
doaj  

Faire les courses, préparer les repas et prendre en charge son conjoint. Postures de femmes retraitées face à la fermeture des commerces alimentaires de proximité

Lien Social et Politiques, 2017
Les courses alimentaires occupent une place centrale dans la vie quotidienne des personnes âgées, cette activité constituant le premier motif de sortie de celles vivant en centre-ville.
Philippe Cardon
doaj   +1 more source

Disrupted Brain Structure and Function in Alzheimer's Disease Patients With Behavioral and Psychological Symptoms

iNew Medicine, EarlyView.
ABSTRACT Objective Behavioral and psychological symptoms of dementia (BPSD) are highly prevalent in Alzheimer’s disease (AD), but the underlying mechanisms are unclear. This study aims to elucidate the neuropathological mechanisms underlying BPSD by investigating gray matter volume (GMV) and brain connectivity in AD patients with and without BPSD ...
Xuerui Pang, Linbo Xie, Mengdan Chen, Yi Ji, Yibing Yan, Shanshan Zhou, Panpan Hu, Xingqi Wu, Kai Wang   +8 more
wiley   +1 more source

HDR

, 2007
Synthèse de la ...
  +6 more sources

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

Modulation of Homology-Directed Repair in T98G Glioblastoma Cells Due to Interactions between Wildtype p53, Rad51 and HCMV IE1-72

Viruses, 2014
Human cytomegalovirus (HCMV) is a ubiquitous pathogen capable of causing life threatening consequences in neonates and immune-compromised individuals. HCMV inflicts site-specific double strand breaks (DSBs) in the cellular genome.
Amit S. Kulkarni, Elizabeth A. Fortunato
doaj   +1 more source