Results 61 to 70 of about 49,453 (252)

‘Free to Be Me?’: Gender Role Norms Constrain Career Interests Less for Lesbian, Gay and Bisexual People Than for Heterosexual People

open access: yesEuropean Journal of Social Psychology, EarlyView.
ABSTRACT Societal gender role norms play a crucial role in shaping men's and women's career aspirations. However, prior research documenting this key role of gendered norms has primarily focused on heterosexual women and men in the global North‐West. Previous studies documenting differences in career interests by sexual orientation suggest that gender ...
Katharina Block   +136 more
wiley   +1 more source

Handwritten digit recognition: Comparative analysis of ML, CNN, vision transformer, and hybrid models on the MNIST dataset

open access: yesJournal of Intelligent Systems
Handwritten digit recognition (HDR) remains challenging due to variations in writing styles. To address this challenge, this study comprehensively compares ML (ML) and deep learning (DL) models. We explored a variety of approaches.
Ben Noureddine Dhouha
doaj   +1 more source

Réparer la nature, est-ce bien raisonnable ? [PDF]

open access: yesSciences, Eaux & Territoires, 2017
Un problème se pose au gestionnaire qui souhaite préserver ou réhabiliter une zone humide : quel état de cette zone en perpétuelle évolution choisir ? Ce parti pris n’est pas anodin : il implique des notions de mémoire, d’héritage, de patrimoine.
DEREX, Jean-Michel
doaj  

Faire les courses, préparer les repas et prendre en charge son conjoint. Postures de femmes retraitées face à la fermeture des commerces alimentaires de proximité

open access: yesLien Social et Politiques, 2017
Les courses alimentaires occupent une place centrale dans la vie quotidienne des personnes âgées, cette activité constituant le premier motif de sortie de celles vivant en centre-ville.
Philippe Cardon
doaj   +1 more source

A first in disease trial of the safety, tolerability, and anti‐seizure effects of ES‐481 in drug‐resistant epilepsy

open access: yesEpilepsia Open, EarlyView.
Abstract Objectives ES‐481 is a novel potent and selective antagonist of TARP‐y8‐dependent AMPA receptors. We aimed to assess the potential efficacy, safety and tolerability, and pharmacokinetics of different doses of ES‐481 as an add‐on anti‐seizure medication (ASM) in adults with drug‐resistant epilepsy (DRE). Methods This was a Phase 2A double‐blind,
Emma C. Foster   +16 more
wiley   +1 more source

Structure-activity relationship study shows versatility in substrate specificity for heterodisulfide reductase in methanogenic archaea. [PDF]

open access: yesProtein Sci
Abstract Hydrogenotrophic methanogens are anaerobic archaea that convert carbon dioxide and hydrogen into methane. Central to this process is the heterodisulfide reductase (Hdr), which catalyzes the reduction of the heterodisulfide made of coenzyme M and coenzyme B. In vivo, Hdr functions in association with electron‐donating modules such as the [NiFe]‐
Maleki MF   +5 more
europepmc   +2 more sources

Generation of Allogeneic CAR‐T Circumvents Functional Deficits in Patient‐Derived Autologous Product for Glioblastoma

open access: yesInternational Journal of Cancer, EarlyView.
Clinical trials of chimeric antigen receptor T‐cell (CAR‐T) therapies in glioblastoma have shown limited clinical benefits. Whether this may be explained by the basal quality of CAR‐T products, which are currently generated using patient, autologous T‐cells, has been little explored.
Sabra K. Salim   +22 more
wiley   +1 more source

Tumor Infiltrating Lymphocyte Therapy Combined With PD‐1/LAG‐3 Inhibition in Patients With Recurrent Platinum‐Resistant Ovarian Cancer

open access: yesInternational Journal of Cancer, EarlyView.
The detection of tumor‐infiltrating lymphocytes (TILs) is a positive prognostic factor in ovarian cancer. Moreover, TILs are significantly boosted by immunotherapy, though ovarian cancer patients have seen limited benefit from immune therapies. This study investigated the safety and feasibility of TIL therapy combined with PD‐1 and LAG‐3 inhibitors in ...
Tine J. Monberg   +9 more
wiley   +1 more source

Modulation of Homology-Directed Repair in T98G Glioblastoma Cells Due to Interactions between Wildtype p53, Rad51 and HCMV IE1-72

open access: yesViruses, 2014
Human cytomegalovirus (HCMV) is a ubiquitous pathogen capable of causing life threatening consequences in neonates and immune-compromised individuals. HCMV inflicts site-specific double strand breaks (DSBs) in the cellular genome.
Amit S. Kulkarni, Elizabeth A. Fortunato
doaj   +1 more source

Constrained Spectral Uplifting for HDR Environment Maps

open access: yes
Spectral representation of assets is an important precondition for achieving physical realism in rendering. However, defining assets by their spectral distribution is complicated and tedious. Therefore, it has become general practice to create RGB assets
Tódová, L., Wilkie, A.
core   +1 more source

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