Results 61 to 70 of about 86,009 (325)

Pathological complete response with immunotherapy and brachytherapy to 15 metastatic liver lesions in a single patient

Hepatic Oncology, 2022
Materials & methods: High dose rate interstitial brachytherapy (HDR-IBT) treatment plan for 15 metastatic liver lesions in a patient with pancreatic cancer was retrieved and analyzed for liver dose parameters and diaphragm dose.
Gokula Kumar Appalanaido, Muhamad Zabidi Ahmad, Syadwa Abdul Shukor, Alex Khoo Cheen Hoe, Manisekar K Subramaniam, Ang Soo Fan, Mohd Zahri Abdul Aziz   +6 more
doaj   +1 more source

RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA

Molecules and Cells, 2022
SUMMARY Alternative lengthening of telomeres (ALT) is a homology-directed repair (HDR) mechanism of telomere elongation that controls proliferation in subsets of aggressive cancer.
N. Kaminski, Anne R. Wondisford, Y. Kwon, M. L. Lynskey, Ragini Bhargava, J. Barroso-González, L. García-Expósito, Boxue He, Meng Xu, Dattatreya Mellacheruvu, Simon C Watkins, M. Modesti, K. M. Miller, A. Nesvizhskii, Huai-Ying Zhang, Patrick M. Sung, Roderick J. O’Sullivan   +16 more
semanticscholar   +1 more source

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Advanced Science, EarlyView.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li, Jiao Qiao, Qiuyuan Zhang, Peipei Liu, Chenjun Zheng, Qi Zhou, Mengqi Ji, Zhihui Zhu, Xiaoxue Li, Hongyu Zhang   +9 more
wiley   +1 more source

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source

Stable Cells with NF-κB-ZsGreen Fused Genes Created by TALEN Editing and Homology Directed Repair for Screening Anti-inflammation Drugs

Journal of Inflammation Research, 2021
Shuyan Zhang, Tao Luo, Jinke Wang State Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096, People’s Republic of ChinaCorrespondence: Jinke WangState Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096 ...
Zhang S, Luo T, Wang J
doaj  

Enhancing homology-directed repair efficiency with HDR-boosting modular ssDNA donor

Nature Communications
Despite the potential of small molecules and recombinant proteins to enhance the efficiency of homology-directed repair (HDR), single-stranded DNA (ssDNA) donors, as currently designed and chemically modified, remain suboptimal for precise gene editing ...
Ying-Ying Jin, Peng Zhang, Lele Liu, Xiang Zhao, Xiaoqing Hu, Si Liu, Zekun Li, Qian Liu, Jianqiao Wang, Delong Hao, Zhu-Qin Zhang, Hou-Zao Chen, Depei Liu   +12 more
semanticscholar   +1 more source

All-In-One Dendrimer-Based Lipid Nanoparticles Enable Precise HDR-Mediated Gene Editing In Vivo

Advances in Materials, 2021
Clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR‐associated (Cas) protein gene editing is poised to transform the treatment of genetic diseases.
L. Farbiak, Qiang Cheng, Tuo Wei, Ester Álvarez-Benedicto, Lindsay T. Johnson, Sang M. Lee, D. Siegwart   +6 more
semanticscholar   +1 more source

Premium Hdr: The Impact of a Singleword on the Quality of Experience of Hdr Video [PDF]

2018 IEEE International Conference on Multimedia & Expo Workshops (ICMEW), 2018
High Dynamic Range (HDR) visualization is converging towards a point where it becomes the de facto standard for multimedia services. Current and future variations in color bit depth, peak brightness, black level and all other characteristics of display and content ultimately lead to a fine-grained market of end-user products with a multitude of ...
Péter A. Kara, Maria G. Martini, Aron Cserkaszky   +2 more
openaire   +2 more sources

RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites

Advanced Science, EarlyView.
At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Yungyeong Heo, Yonghyeon Kim, Nangyeong Hwang, Gwanho Sung, Sujin Jo, Yeonhu Lee, Ho‐Chul Kang, Jae‐Ho Lee, Yong Won Choi, Hyeseong Cho, Sunwoo Min   +10 more
wiley   +1 more source

Tone rendering vs tone mapping : the history and practice of HDR imaging

, 2013
An invited critical survey about the history and the practice of HDR ...
A. Rizzi
core   +2 more sources