Results 81 to 90 of about 110,403 (278)

Handwritten digit recognition: Comparative analysis of ML, CNN, vision transformer, and hybrid models on the MNIST dataset

Journal of Intelligent Systems
Handwritten digit recognition (HDR) remains challenging due to variations in writing styles. To address this challenge, this study comprehensively compares ML (ML) and deep learning (DL) models. We explored a variety of approaches.
Ben Noureddine Dhouha
doaj   +1 more source

Modulation of Homology-Directed Repair in T98G Glioblastoma Cells Due to Interactions between Wildtype p53, Rad51 and HCMV IE1-72

Viruses, 2014
Human cytomegalovirus (HCMV) is a ubiquitous pathogen capable of causing life threatening consequences in neonates and immune-compromised individuals. HCMV inflicts site-specific double strand breaks (DSBs) in the cellular genome.
Amit S. Kulkarni, Elizabeth A. Fortunato
doaj   +1 more source

Generation of Allogeneic CAR‐T Circumvents Functional Deficits in Patient‐Derived Autologous Product for Glioblastoma

International Journal of Cancer, EarlyView.
Clinical trials of chimeric antigen receptor T‐cell (CAR‐T) therapies in glioblastoma have shown limited clinical benefits. Whether this may be explained by the basal quality of CAR‐T products, which are currently generated using patient, autologous T‐cells, has been little explored.
Sabra K. Salim, Muhammad Vaseem Shaikh, Jeffrey Wei, William T. Maich, Alisha Anand, Oliver Y. Tang, Minomi K. Subapanditha, Zahra Alizada, Yujin Suk, Manoj Singh, Kui Zhai, Aapti Khanna, Benjamin Brakel, Vassil Dimitrov, Zoya Tabunshchyk, Katie Chan, Kevin R. Brown, Parvez Vora, Donald M. O'Rourke, Zev A. Binder, Chitra Venugopal, Jason Moffat, Sheila K. Singh   +22 more
wiley   +1 more source

Tumor Infiltrating Lymphocyte Therapy Combined With PD‐1/LAG‐3 Inhibition in Patients With Recurrent Platinum‐Resistant Ovarian Cancer

International Journal of Cancer, EarlyView.
The detection of tumor‐infiltrating lymphocytes (TILs) is a positive prognostic factor in ovarian cancer. Moreover, TILs are significantly boosted by immunotherapy, though ovarian cancer patients have seen limited benefit from immune therapies. This study investigated the safety and feasibility of TIL therapy combined with PD‐1 and LAG‐3 inhibitors in ...
Tine J. Monberg, Cathrine L. Lorentzen, Marie C. W. Westergaard, Trine Z. Iversen, Troels H. Borch, Marco Donia, Sigrid M. Mannering, Stine E. W. Banke, Özcan Met, Inge Marie Svane   +9 more
wiley   +1 more source

Do Internet‐Driven Trade Shocks Moderate the Exchange Rate Pass‐Through to Inflation?

International Journal of Finance &Economics, EarlyView.
ABSTRACT This study examines the existence of an internet globalisation intensifying impact on the size of the exchange rate pass‐through (ERPT) to inflation, which conditions the response of central banks' policy rates. Expanding on the traditional determinants of ERPT, we incorporate technology‐induced trade shocks linked to internet adoption to ...
Joanna Darwiche, Nicole Ballouz Baker
wiley   +1 more source

CRISPR-Cas9-mediated homology-directed repair for precise gene editing

Molecular Therapy: Nucleic Acids
CRISPR-Cas9-mediated homology-directed repair (HDR) is a versatile platform for creating precise site-specific DNA insertions, deletions, and substitutions. These precise edits are made possible through the use of exogenous donor templates that carry the
Hongyu Liao, Jiahao Wu, Nathan J. VanDusen, Yifei Li, Yanjiang Zheng   +4 more
doaj   +1 more source

Disrupted Brain Structure and Function in Alzheimer's Disease Patients With Behavioral and Psychological Symptoms

iNew Medicine, EarlyView.
ABSTRACT Behavioral and psychological symptoms of dementia (BPSD) are highly prevalent in Alzheimer's disease (AD), but the underlying mechanisms are unclear. This study aims to elucidate the neuropathological mechanisms underlying BPSD by investigating gray matter volume (GMV) and brain connectivity in AD patients with and without BPSD.
Xuerui Pang, Linbo Xie, Mengdan Chen, Yi Ji, Yibing Yan, Shanshan Zhou, Panpan Hu, Xingqi Wu, Kai Wang   +8 more
wiley   +1 more source

Interactions entre les différents protagonistes d’un do [PDF]

Cinema & Território, 2018
La méthode du documentaire en lien avec les interactions possibles entre ses protagonistes (filmeur, filmé et spectateur) va dans un premier temps aider à définir les identités de ces participants à la construction du film documentaire. Puis, ce sont les
Natacha CYRULNIK
doaj  

Chemical conjunctivitis and diffuse lamellar keratitis after removal of eyelash extensions

American Journal of Ophthalmology Case Reports, 2018
Purpose: There have been several reports in the literature demonstrating the adverse effects of multiple ocular cosmetic procedures, such as eyelash extensions, eyeliner tattoo, and eyelash dyeing.
Majid Moshirfar, Maliha Masud, Tirth J. Shah, Michele R. Avila, Phillip C. Hoopes, Sr.   +4 more
doaj   +1 more source

Recent Advances in Thalassemia Research: A Comprehensive Assessment From Diagnostic Technologies to Clinical Treatment

Journal of Clinical Laboratory Analysis, EarlyView.
Thalassemia, a common hereditary blood disorder causing impaired globin synthesis and related complications, has seen remarkable progress in recent years due to advancements in genomics and molecular biology. Researchers have identified various gene variants related to thalassemia and improved clinical diagnostic methods, including new genetic testing ...
Chaoqiong Zhou, Ting Chen, Ying Huang, Huali Wang, Dahai He, Feng Wu, Yan Zhang, Lirui Kong   +7 more
wiley   +1 more source