Results 81 to 90 of about 108,215 (261)

Clinical assessment of mocravimod as a victim of drug–drug interactions via CYP3A4 metabolism and transporters

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Mocravimod, a novel immunomodulator targeting sphingosine‐1‐phosphate receptor (S1PR), is being developed as a maintenance treatment for patients with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation. Preclinical data suggested that cytochrome (CYP) 3A4 is the primary enzyme involved in mocravimod metabolism.
Dymphy R. Huntjens, Stephan Oehen, Elisabeth Kueenburg   +2 more
wiley   +1 more source

Mechanical property variation mechanisms of granite subjected to real‐time high temperatures and subsequent cooling treatment

Deep Underground Science and Engineering, EarlyView.
This study investigates the coupled thermo‐mechanical behavior of granite during heating and cooling through a combination of laboratory tests and finite element analysis. The thermal conductivity, mineral composition, mass loss rate, micro‐crack observation, and thermal fracture characteristics of granite under various temperature conditions are ...
Rui Pang, Dehao Meng, Thomas Frühwirt, Hao Liu, Yanan Zhao, Qingyou Zhu, Wengang Dang, Mohamed Ismael, Fei Wang   +8 more
wiley   +1 more source

CRISPR-Cas9-mediated homology-directed repair for precise gene editing

Molecular Therapy: Nucleic Acids
CRISPR-Cas9-mediated homology-directed repair (HDR) is a versatile platform for creating precise site-specific DNA insertions, deletions, and substitutions. These precise edits are made possible through the use of exogenous donor templates that carry the
Hongyu Liao, Jiahao Wu, Nathan J. VanDusen, Yifei Li, Yanjiang Zheng   +4 more
doaj   +1 more source

Caving‐enhanced geothermal system overwhelms fracturing‐ and pipe‐enhanced geothermal system in heat extraction

Deep Underground Science and Engineering, EarlyView.
Our study reveals that caving‐enhanced geothermal systems (C‐EGS) with adequately fractured reservoirs achieve optimal heat extraction by minimizing preferential flow paths, while conventional fracturing (F‐EGS) and pipe‐based (P‐EGS) systems suffer accelerated thermal drawdown.
Fangchao Kang, Tianjiao Li, Yingchun Li, Jinlong Men, Chun'an Tang   +4 more
wiley   +1 more source

Community gets you through: Success factors contributing to the retention of Aboriginal and Torres Strait Islander Higher Degree by Research (HDR) students

Student Success, 2018
This paper explores success factors contributing to the retention of Aboriginal and Torres Strait Islander Higher Degree by Research (HDR) students identified through a National Teaching Fellowship.
Katelyn Barney
doaj   +1 more source

Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle

Developmental Dynamics, EarlyView.
Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell, Tracy Eng, Jeffrey D. Amack, David Pruyne   +3 more
wiley   +1 more source

Interactions entre les différents protagonistes d’un do [PDF]

Cinema & Território, 2018
La méthode du documentaire en lien avec les interactions possibles entre ses protagonistes (filmeur, filmé et spectateur) va dans un premier temps aider à définir les identités de ces participants à la construction du film documentaire. Puis, ce sont les
Natacha CYRULNIK
doaj  

Chemical conjunctivitis and diffuse lamellar keratitis after removal of eyelash extensions

American Journal of Ophthalmology Case Reports, 2018
Purpose: There have been several reports in the literature demonstrating the adverse effects of multiple ocular cosmetic procedures, such as eyelash extensions, eyeliner tattoo, and eyelash dyeing.
Majid Moshirfar, Maliha Masud, Tirth J. Shah, Michele R. Avila, Phillip C. Hoopes, Sr.   +4 more
doaj   +1 more source

HDR-DANet: Single HDR Image Reconstruction via Dual Attention

Multimedia Systems
Abstract Restoring high dynamic range images with a single low dynamic range image is a challenging task due to the limited brightness range captured by most consumer camera sensors, leading to missing details in overexposed or underexposed areas of the image. The current methods suffer from weak reconstruction ability for inconspicuous complex
Jindong Ma, Haitao Zhang
openaire   +1 more source

Seismic Design of Concrete Dams: An Integrated Risk‐Informed Performance‐Based (RIPB) Framework

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT This paper advances the integration of risk‐informed principles into the seismic design of dams—a domain long guided by standards‐based, largely deterministic approaches. While performance‐based earthquake engineering is well established for buildings and bridges, its systematic adoption in dam engineering remains limited. We first address two
M. Amin Hariri‐Ardebili, Larry K. Nuss
wiley   +1 more source