Results 101 to 110 of about 346,276 (308)

Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma

Advanced Science, EarlyView.
SOX2 upregulates KAT7 in glioma stem cells, where KAT7 deposits H3K14 acetylation at the RAC2 promoter to activate RAC2 transcription. RAC2‐GTP subsequently promotes PAK1/2/3 phosphorylation, increasing tricarboxylic acid cycle flux and mitochondrial respiration to support glioblastoma malignancy.
Jilong Liu, Yanfei Sun, Yuehua Zhu, Guangjing Mu, Jiazheng Wang, Liangliang Wang, Feihu Zhao, Zhimin Zhao, Jian Wang, Ying He, Zheng Jiang, Xingang Li, Mingzhi Han, Bin Huang   +13 more
wiley   +1 more source

Oncologic outcome of marginal mandibulectomy in squamous cell carcinoma of the lower gingiva

BMC Cancer, 2019
Background There is a large amount of controversy about the best management of the mandible in oral squamous cell carcinoma (SCC), mainly owing to the inability to acquire accurate bone invasion status.
Wei Du, Qigen Fang, Yao Wu, Junfu Wu, Xu Zhang   +4 more
doaj   +1 more source

Self‐Propelled HPB@Lip@AB Nanomotors Ameliorate Dry Eye Disease

Advanced Science, EarlyView.
A self‐propelled HPB@Lip@AB nanomotor system is developed for dry eye disease (DED) therapy, facilitating rapid penetration across ocular surface barriers while integrating hydrogen therapy with multi‐enzyme‐like antioxidant activity. The nanoplatform restores mitochondrial function, suppresses oxidative stress, inflammation, and apoptosis, and ...
Jing Li, Xi Wan, Xinru Su, Zechuan Li, Yue Wang, Ying Wang, Ruofei Li, Huangzhao Wei, Jianbin Zhang, Shuai Wang   +9 more
wiley   +1 more source

Early mortality after diagnosis of cancer of the head and neck – A population-based nationwide study [PDF]

, 2019
Background Cancers of the head and neck have a high mortality rate, and roughly 10% of the patients die within six months of diagnosis. To our knowledge little has been written about this group.
Laurell, Göran,, Laurell, G., Holmberg, Erik, Lovisa Farnebo, Antti Mäkitie, Göran Laurell, Farnebo, L., Farnebo, Lovisa, Erik Holmberg, Laurell, Göran, Mäkitie, Antti,, Talani, Charbél, Talani, C., Mäkitie, Antti, Charbél Talani, Farnebo, Lovisa,, Martin Beran, Beran, Martin, Mäkitie, A., Talani, Charbél,, Beran, M., Holmberg, Erik,, Beran, Martin,, Beran, M, Farnebo, L, Talani, C, Laurell, G, Holmberg, E, Makitie, A   +28 more
core   +1 more source

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

Evaluating the manubrium sterni as a site for bone implantation: a 3D radiological feasibility study

European Radiology Experimental
Background To increase the number of patients who can speak hands-free after total laryngectomy, we aim to assess the viability of the manubrium sterni bone (MSB) for bone implantation.
Max Johannes Dullaart, Maarten Jan Antony van Alphen, Annelieke Boudina Schoen, Margje Bertine Buitenhuis, Loes Margaretha Marie Braun, Menno Krap, Michiel Wilhelmus Maria van den Brekel, Luc Hendricus Elizabeth Karssemakers, Richard Dirven   +8 more
doaj   +1 more source

5-Aza-2′-deoxycytidin (Decitabine) increases cancer-testis antigen expression in head and neck squamous cell carcinoma and modifies immune checkpoint expression, especially in CD39-positive CD8 and CD4 T cells

Neoplasia: An International Journal for Oncology Research
Failure of immunotherapy in head and neck squamous cell carcinoma (HNSCC) patients represents an unmet need to augment leverage of adaptive immunity. Immunogenic cancer-testis antigen (CTA) expression as well as lymphocyte differentiation and function ...
Adrian Fehn, Adrian von Witzleben, Ayla Grages, Tsima Abou Kors, Jasmin Ezić, Annika C. Betzler, Cornelia Brunner, Patrick J. Schuler, Marie-Nicole Theodoraki, Thomas K. Hoffmann, Simon Laban   +10 more
doaj   +1 more source

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

The endoplasmic reticulum stress-ferroptosis reciprocal signaling orchestrates anti-tumor effect of anlotinib in anaplastic thyroid cancer

Cancer Cell International
Background Ferroptosis-induced therapy is a promising approach for treating anaplastic thyroid carcinoma (ATC), a highly lethal form of cancer. However, the specific effects of two anti-angiogenic agents, lenvatinib and anlotinib, on ferroptosis in ATC ...
Yehao Guo, Juyong Liang, Lingling Ding, Jiajun Wu, Weidong Teng, Jiafeng Wang, Liehao Jiang, Zhuo Tan   +7 more
doaj   +1 more source

Harmonic scalpel in head and neck cancer: Thiroyd surgery.

, 2010
harmonic scalpel in head and neck cancer: thiroyd ...
Spinato R., Abramo A., Spinato G., RUSSOLO, MARIO, TIRELLI, GIAN CARLO   +4 more
core