Results 111 to 120 of about 346,276 (308)

DDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2‐Mediated DNA Damage Response

Advanced Science, EarlyView.
DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Tianru Yang, Ting Shen, Yanfang Qiu, Wei Zhang, Ziran Zheng, Jiayi Sun, Yuedi Yao, Mianfeng Yao, Jiang Li   +8 more
wiley   +1 more source

Medial sural artery perforator free flap for small- to medium-sized defects in head and neck reconstruction: a suitable replacement for radial forearm free flap

Maxillofacial Plastic and Reconstructive Surgery
Background and objectives To compare clinical outcomes and donor site morbidity between medial sural artery perforator (MSAP) flap and radial forearm free (RFF) flap for soft tissue reconstruction of head and neck.
Yulian Zhang, Keran Pan, Jian Wu, Xi Tang   +3 more
doaj   +1 more source

A General High‐Throughput Mucus Microrheology Platform for Quantitative and Scalable Mucus Phenotyping

Advanced Science, EarlyView.
High‐throughput Differential Dynamic Microscopy measures frequency‐resolved mechanical fingerprints from 3 to 10 μL$\umu{\rm L}$ mucus samples using only a few minutes of operator attention per sample. This automated analysis enables scalable mucus phenotyping for translational research by distinguishing mechanical heterogeneity among donors, disease ...
Feng Ling, Ayşe Tuğçe Şahin, Bernardo Miller Naranjo, Stefano Aime, Doris Roth, Anna Pukaluk, Niels Tepho, Romina Augustin, Benedetta Zampa, Andrea S. Vendrame, Mark‐Christian Klassen, Ellen Emken, Marion Kiechle, Mircea Gabriel Stoleriu, Pontus Mertsch, Ruth Olmer, Yohannes Tesfaigzi, Oliver Lieleg, Janna C. Nawroth   +18 more
wiley   +1 more source

Correction: Pim-1 acts as an oncogene in human salivary gland adenoid cystic carcinoma

Journal of Experimental & Clinical Cancer Research, 2022
Xin Zhu, Jia-jie Xu, Si-si Hu, Jian-guo Feng, Lie-hao Jiang, Xiu-xiu Hou, Jun Cao, Jing Han, Zhi-qiang Ling, Ming-hua Ge   +9 more
doaj   +1 more source

Predictive risk-scoring model for lateral lymph node metastasis in papillary thyroid carcinoma

Scientific Reports
This study aims to evaluate candidate risk factors for lateral lymph node metastasis (LLNM) and develop a predictive model to identify high-risk groups among patients with papillary thyroid carcinoma (PTC).
Yehao Guo, Yunye Liu, Weidong Teng, Yan Pan, Lizhuo Zhang, Dongdong Feng, Jiajun Wu, Wenli Ma, Jiafeng Wang, Jiajie Xu, Chuanming Zheng, Xuhang Zhu, Zhuo Tan, Liehao Jiang   +13 more
doaj   +1 more source

Assembled Hyaluronic Acid Therapeutics for Targeting M1 Macrophages and Regulating Immune Homeostasis for Ulcerative Colitis Treatment

Advanced Science, EarlyView.
An orally administered, drug‐free hyaluronic acid nanoassembly, uhNAs‐OA, accumulates in the inflamed colon and is preferentially internalized by M1‐like macrophages via HA‐CD44 interactions. uhNAs‐OA scavenges excess ROS, suppresses NF‐κB signaling and remodels the colonic immune landscape, resulting in robust therapeutic efficacy in acute, chronic ...
Jianqin Wan, Andi Ma, Yiqiong Zhang, Minghao Zhang, Yifeng Lin, Xiaoling Zhang, Hongjun Li, Weidong Han   +7 more
wiley   +1 more source

EBV-positive small cell neuroendocrine carcinoma of the nasopharynx with cervical lymph node metastasis: a case report and literature review

Frontiers in Oncology
PurposeInvestigating the diagnosis and treatment of Epstein-Barr virus-positive small cell neuroendocrine carcinomas of the nasopharynx with cervical lymph node metastasis.MethodsThe clinical data of a patient with Epstein-Barr virus-positive small cell ...
Jincai Xue, Wenjuan Ma, Xudong Liu, Yunsheng Wang, Xingyue Wang, Zhihu Li, Youxin Tian, Qinjiang Liu, Fang Dong   +8 more
doaj   +1 more source

CT-PET guided target delineation in head and neck cancer and implications for improved outcome [PDF]

, 2010
Aim: Fifty percent of patients with squamous cell carcinoma of the Head and Neck develop loco-regional recurrence after treatment. Factors leading to this failure are most likely altered intra-tumoural glucose metabolism and increased hypoxia ...
Moule, R.N.
core  

Role of human papillomavirus in the etiology of head and neck cancer

, 2006
Head and neck cancer is the world's sixth most common cancer, but despite advances in treatment, there has been no significant decline in the mortality rate.
Tran, N, Rose, BR, O'Brien, CJ, Christopher J. O’brien, Barbara R. Rose, Nham Tran, Robert L. Ferris   +6 more
core   +1 more source

Optimizing Cancer Vaccinations Using a Physiologically‐Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Model

Advanced Science, EarlyView.
Where and when should a cancer vaccine be administered? A whole‐body PBPK model demonstrates that systemic immune transport critically determines vaccination efficacy. By simulating how organ‐specific immune interactions influence treatment response, the study provides a quantitative framework for optimizing cancer vaccination strategies.
Mohammad R. Nikmaneshi, Timothy P. Padera, Lance L. Munn   +2 more
wiley   +1 more source