Results 111 to 120 of about 557,930 (311)

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

mTOR inhibitor use in head and neck squamous cell carcinoma: A meta‐analysis on survival, tumor response, and toxicity

Laryngoscope Investigative Otolaryngology, 2020
Background Head and neck squamous cell carcinoma (HNSCC) has been rising in incidence primarily related to HPV‐associated oropharyngeal cancers. Novel molecular therapeutics are evolving with the mTOR pathway as a new target.
Jaimin Patel, Shaun A. Nguyen, Besim Ogretmen, Jorge S. Gutkind, Cherie‐Ann Nathan, Terry Day   +5 more
doaj   +1 more source

Evaluation of shoulder disability questionnaires used for the assessment of shoulder disability after neck dissection for head and neck cancer [PDF]

, 2014
Background Several questionnaires have been used to evaluate shoulder disability after neck dissection. The purpose of this study was to review these measures and highlight their strengths and weaknesses. Methods A literature review was performed to
Angst, Angst, Angst, Beaton, Beaton, Bot, Breckenridge, Bushnell, Chepeha, Conboy, Constant, Desai, Getahun, Gliklich, Goldstein, Heijden, Hudak, Jamnik, John, Kirkley, Kirkley, Kirkley, Kocher, Marchese, McClure, Michener, Michener, Mokkink, Novak, Padua, Richards, Roach, Roy, Solway, Taylor, Winter   +35 more
core   +1 more source

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Evaluating the manubrium sterni as a site for bone implantation: a 3D radiological feasibility study

European Radiology Experimental
Background To increase the number of patients who can speak hands-free after total laryngectomy, we aim to assess the viability of the manubrium sterni bone (MSB) for bone implantation.
Max Johannes Dullaart, Maarten Jan Antony van Alphen, Annelieke Boudina Schoen, Margje Bertine Buitenhuis, Loes Margaretha Marie Braun, Menno Krap, Michiel Wilhelmus Maria van den Brekel, Luc Hendricus Elizabeth Karssemakers, Richard Dirven   +8 more
doaj   +1 more source

Impending carotid blowout stabilization using an LT-D tube [PDF]

, 2014
Adequate stabilization of a patient presenting with a carotid blowout is one of the most challenging issues an on-call ENT surgeon can be confronted with. Reducing the bleeding and securing the airway are essential before more definitive management.
Desuter, G., Francois, P. M., Gardiner, Q., Gregoire, A.   +3 more
core   +6 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource:head and neck 5000 [PDF]

, 2014
BACKGROUND: Head and neck cancer is an important cause of ill health. Survival appears to be improving but the reasons for this are unclear. They could include evolving aetiology, modifications in care, improvements in treatment or changes in lifestyle ...
Abdelkader, Maged, Ahmed, Imtiaz, Allmark, Christine, Anari, Shahram, Andrade, Gerard, Baldwin, Andrew, Balfour, Alistair, Barnes, Debi, Beaumont-Jewell, Dawn, Benson, Richard, Berry, Sandeep, Bisase, Brian, Brammer, Caroline, Carr, Ruth, Casasola, Richard, Christian, Judith, Coatesworth, Andrew, Cogill, Geoffrey, Cole, Naomi, Conway, David, Dallas, Nicola, Davies, Joe, Doyle, Margret, Dyker, Karen, Dyson, P, England, James, Evans, Andrew, Evans, Mererid, Fisher, Sheila, Foran, Bernie, Forster, Martin, Fresco, Lydia, Gahir, Daljit, Gollins, Simon, Goodchild, Kate, Gunasekaran, Sinnappa P, Hall, Charles, Hamid, Abdel, Hari, Churunal, Hollingworth, Will, Homer, Jarrod, Hurley, Katrina, Hwang, David, Hyde, Nicholas, Jankowska, Petra, Jeffreys, Mona, Kim, Dae, King, Emma, Lamont, Alan, Leary, Sam, Lees, Laura, Lester, Jim, Lester, Shane, Loo, H W, Lowe, Rachel, Mano, Joseph, McAllister, Ken, McCaul, James, Mehanna, Hisham, Moss, Laura, Moule, Russell, Ness, Andrew Robert, Nutting, Chris, Nutting, Christopher, O'Hara, James, Palaniappan, Nachi, Paleri, Vinidh, Penfold, Chris, Persson, Martin, Peters, Tim J, Pring, Miranda, Repanos, Costas, Richards, Stuart, Ring, Susan, Rogers, Simon, Roques, Tom, Rowell, Nick, Roy, Amy, Scrase, Christopher, Sen, Mehmet, Sheehan, Tom, Simcock, Richard, Siva, Muthu, Stewart, Simon, Tatla, Taran, Thiruchelvam, J K, Thomas, Steve, Tierney, Paul, Toms, Stu, Tyler, Jayne, Wagstaff, Lynda, Waldron, John, Waylen, Andrea, Wight, Richard, Winter, Stuart, Wood, Christine, Wood, Katie, Worthington, Helen   +97 more
core   +5 more sources

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Oncologic outcome of marginal mandibulectomy in squamous cell carcinoma of the lower gingiva

BMC Cancer, 2019
Background There is a large amount of controversy about the best management of the mandible in oral squamous cell carcinoma (SCC), mainly owing to the inability to acquire accurate bone invasion status.
Wei Du, Qigen Fang, Yao Wu, Junfu Wu, Xu Zhang   +4 more
doaj   +1 more source