Results 91 to 100 of about 315,615 (312)

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Transforming Growth Factor Alpha Stimulation of Mucosal Tissue Cultures from Head and Neck Squamous Cell Carcinoma Patients Increases Chemoresistance to Cisplatin [PDF]

, 2010
The monoclonal epidermal growth factor receptor ( EGFR) antibody cetuximab (Erbitux(TM)) was recently approved by the European Medicines Agency for the treatment of recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) in combination ...
Baumeister, Philipp, Ulrich Harréus, Schwenk-Zieger, Sabina, Maximilian Reiter, Philipp Baumeister, Reiter, Maximilian, Sabina Schwenk-Zieger, Harreus, Ulrich   +7 more
core   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

‐19 pandemic

, 2020
The COVID‐19 pandemic has had a significant impact on many aspects of head and neck cancer (HNC) care. The uncertainty and stress resulting from these changes has led many patients and caregivers to turn to HNC advocacy groups for guidance and support ...
Tsue, Terance T., Rauscher, Erika, Caputo, Mary Ann, Ready, John, Terance T. Tsue, Yan, Flora, Moore, Michael G., Michael G. Moore, Fakhary, Carole, Amanda Hollinger, John Ready, Cherie‐Ann O. Nathan, Nathan, Cherie-Ann O., Flora Yan, Danielle Yearout, Mary Ann Caputo, Carole Fakhry, Terry A. Day, Leonardis, Chris, Erika Rauscher, Yearout, Danielle, Day, Terry A., Hollinger, Amanda, Fakhry, Carole, Chris Leonardis   +24 more
core   +1 more source

Optimal perioperative care in major head and neck cancer surgery with free flap reconstruction [PDF]

, 2017
Importance: Head and neck cancers often require complex, labor-intensive surgeries, especially when free flap reconstruction is required. Enhanced recovery is important in this patient population but evidence-based protocols on perioperative care for ...
Findlay, Merran,, Harris, Jeffrey,, Shea-Budgell, Melissa A, Zygun, David, Shea-Budgell, M.A., Simon, C, Simon, Christian,, Shea-Budgell, Melissa A.,, Findlay, M., Simon, C., Huber, Gerhard F.,, Zygun, D, Huber, G.F., Harris, Jeffrey, Dort, J.C., Huber, Gerhard F, Ljungqvist, O., Farwell, DG, Farwell, D. Gregory,, Kerr, Paul, Uppington, Jeffrey, Uppington, J., Ljungqvist, O,, Zygun, David,, Farwell, D.G., Dort, Joseph C.,, Harris, J., Kerr, P, Uppington, Jeffrey,, Huber, GF, Farwell, D Gregory, Shea-Budgell, MA, Kerr, Paul,, Findlay, Merran, Uppington, J, Simon, Christian, Zygun, D., Dort, JC, Dort, Joseph C, Kerr, P., Ljungqvist, Olle, Findlay, M, Ljungqvist, Olle,   +42 more
core   +1 more source

Evaluating the manubrium sterni as a site for bone implantation: a 3D radiological feasibility study

European Radiology Experimental
Background To increase the number of patients who can speak hands-free after total laryngectomy, we aim to assess the viability of the manubrium sterni bone (MSB) for bone implantation.
Max Johannes Dullaart, Maarten Jan Antony van Alphen, Annelieke Boudina Schoen, Margje Bertine Buitenhuis, Loes Margaretha Marie Braun, Menno Krap, Michiel Wilhelmus Maria van den Brekel, Luc Hendricus Elizabeth Karssemakers, Richard Dirven   +8 more
doaj   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Molecular Characterization of ‘p53 Family Network’ in Human Head and Neck Cancer and Anti-EGFR Therapy

, 2008
Understanding of p53 family protein (p53, p63 and p73) networks in head and neck squamous cell carcinoma (HNSCC), can positively influence in cancer screening, diagnosis, treatment and prevention.
Sebastian, Sinto
core  

Plasma circulating tumor DNA as a potential tool for disease monitoring in head and neck cancer

, 2019
Recommendations for perioperative therapy in head and neck cancer are not explicit and recurrence occurs frequently. Circulating tumor DNA is an emerging cancer biomarker, but has not been extensively explored for detection of recurrence in head and neck
Anders Ståhlberg, Saunders, Stefanie, Tony E. Godfrey, Irina Kalatskaya, Krzyzanowski, Paul M, Anand Devaiah, Paul M. Krzyzanowski, Stefanie Saunders, Ståhlberg, Anders,, Devaiah, Anand, Filges, Stefan,, Jalisi, Scharukh, Stein, Lincoln D, Sridhar, Praveen, Godfrey, Tony E, Egyud, Matthew, Jiao, Wei, Lincoln D. Stein, Stefan Filges, Scharukh Jalisi, Matthew Egyud, Yamada, Emiko, Praveen Sridhar, Emiko Yamada, Wei Jiao, Kalatskaya, Irina   +25 more
core   +1 more source

Nasopharyngeal cancer risk assessment by country or region worldwide from 1990 to 2019

BMC Public Health
Background Nasopharyngeal carcinoma (NPC) is 22nd most common cancer that occurs all over the world, but the prevalence rate can exhibit significant geographical differences.
Xian Wei, Biaoyou Chen, Zihao Wang, Peng Zhao, Xuwei Duan   +4 more
doaj   +1 more source