Results 71 to 80 of about 556,406 (311)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Factors associated with delay in diagnosis of oral cancers

Cancer Treatment and Research Communications
Background: Oral cancer is one of the ten most common malignancies in the world and approximately 90 % of cases are OSCC. Despite the progress in available treatment modalities, the mortality of patients with OSCC has remained steadily high during the ...
Deepa Swaminathan, Nebu Abraham George, Shaji Thomas, Elizabeth Mathew Iype   +3 more
doaj   +1 more source

Skip metastasis in papillary thyroid carcinoma is difficult to predict in clinical practice

BMC Cancer, 2017
Background Cervical lymph node metastases are very common in papillary thyroid cancer (PTC), and typically spread in a predictable stepwise fashion in clinical practice. However, lateral lymph node metastasis (LLNM) without central lymph node metastasis (
Xilin Nie, Zhou Tan, Minghua Ge
doaj   +1 more source

Lembo miofasciale di vasto laterale nella ricostruzione della lingua [PDF]

Acta Otorhinolaryngologica Italica, 2016
Nell'ultimo decennio il lembo antero-laterale di coscia (ALT) è diventato il lembo libero più utilizzato nella ricostruzione della lingua, dal momento che esso è caratterizzato da bassa morbidità a livello del sito donatore e da migliori risultati ...
R. Pellini, A. De Virgilio, G. Mercante, B. Pichi, V. Manciocco, P. Marchesi, F. Ferreli, G. Spriano   +7 more
doaj   +1 more source

Oral and maxillofacial rehabilitation of head and neck cancer patients [PDF]

, 2009
The general aim of this paper was to gain insight into the effects of maxillofacial rehabilitation in head and neck cancer patients using implantretained prostheses regarding treatment planning, implant survival, treatment outcome and quality of life. In
Kocev, Pavle, Milosev, Vladimir, Miloseva, Lence   +2 more
core  

AHNAK and inflammatory markers predict poor survival in laryngeal carcinoma. [PDF]

, 2012
AHNAK/Desmoyokin is a giant protein which has been recently linked to reorganization of the actin cytoskeleton, cellular migration and invasion. Here, we investigated the role of AHNAK in the pathophysiology of larynx carcinoma-one of the major subtypes ...
Bankfalvi, Agnes, Brandau, Sven, Dumitru, Claudia A., Gu, Xiang, Lang, Stephan, Zeidler, Reinhard   +5 more
core   +2 more sources

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Improving therapeutic ratio In head and neck cancer with adjuvant and cisplatin-based treatments [PDF]

, 2013
Advanced head and neck cancers are difficult to manage despite the large treatment arsenal currently available. The multidisciplinary effort to increase disease-free survival and diminish normal tissue toxicity was rewarded with better locoregional ...
Marcu, L.
core   +3 more sources

Neuroinflammation in GAD65 Antibody‐Associated Epilepsy Measured Using [18F]DPA‐714 PET/MRI

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The timing for initiating immunotherapy in patients with glutamic acid decarboxylase 65 (GAD65) antibody‐associated epilepsy is a challenge. We used the translocator protein radioligand [18F]DPA‐714 and PET to evaluate brain microglial activation.
Jingjing Chen, Yuying Zhang, Heyu Zhang, Jinming Zhang, Ningning Wang, Xintong Guo, Yicong Liu, Yue Liu, Xiangsong Zhang, Ziyi Chen, Guanzhong Ni   +10 more
wiley   +1 more source

RAD51C – a new human cancer susceptibility gene for sporadic squamous cell carcinoma of the head and neck (HNSCC) [PDF]

, 2014
INTRODUCTION: Head and neck squamous cell carcinomas (HNSSCs) are one of the leading causes of cancer-associated death worldwide. Although certain behavioral risk factors are well recognized as tumor promoting, there is very little known about the ...
Baldus, Stephan E., Balz, Vera, Freund, Marcel, Hanenberg, Helmut, Pakropa, Petra, Scheckenbach, Kathrin, Schipper, Jörg, Schäfer, Karl-Ludwig, Sproll, Christoph, Wagenmann, Martin   +9 more
core   +1 more source