Results 81 to 90 of about 315,615 (312)

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Retropharyngeal Lymph Node Metastases in Head and Neck Malignancies

, 2010
Item does not contain fulltextRetropharyngeal lymph node (RPLN) metastasis of primary head and neck cancer often receives less consideration than lymph node metastasis in the neck. With improvements in imaging techniques and reports of surgical pathology,
Shaha, Ashok R., Medina, JE, Robbins, KT, Woolgar, J.A., Bree, R. de, H. Hakan Coskun, Remco de Bree, Ferlito, Alfio, Robbins, K. Thomas, Takes, Robert P., Alessandra Rinaldo, Rinaldo, Alessandra, Juan P. Rodrigo, Rinaldo, A, Strojan, Primoz, Rodrigo, Juan P., Suarez, Carlos, Takes, R.P., Shaha, AR, Ferlito, A., Robbins, K.T., Alfio Ferlito, Woolgar, Julia A., Julia A. Woolgar, de Bree, Remco, Jesus E. Medina, Robert P. Takes, Silver, Carl E., Coskun, H.H., Strojan, P., Carlos Suárez, K. Thomas Robbins, de Bree, R., Medina, J.E., Ashok R. Shaha, Suarez, C., Silver, C.E., Shaha, A.R., Ferlito, A, Primož Strojan, Rodrigo, J.P., Medina, Jesus E., Rinaldo, A., Carl E. Silver   +43 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Weight loss in head and neck cancer patients little noticed in general practice

, 2010
INTRODUCTION: In head and neck cancer patients, weight loss increases morbidity and mortality, and decreases treatment tolerance and quality of life. Early nutritional intervention has beneficial effects on these factors.
Weel, C., van, Merkx, M.A.W., Rasmussen-Conrad, E., Berg, M.G.A., van den, Wayenburg, C.A.M., van, Staveren, W.A., van, Binsbergen, J.J., van   +6 more
core  

Pituitary tumor-transforming gene expression is a prognostic marker for tumor recurrence in squamous cell carcinoma of the head and neck

, 2006
Background The proto-oncogene pituitary tumor-transforming gene (PTTG) has been shown to be abundantly overexpressed in a large variety of neoplasms likely promoting neo-vascularization and tumor invasiveness.
Solbach, Christine, Peters Silke, Eckerdt, Frank, Peters, Silke, Knecht, Rainald, Roller, Marc, Roller Marc, Eckerdt Frank, Solbach Christine, Knecht Rainald   +9 more
core   +1 more source

An Update of the Appropriate Treatment Strategies in Anaplastic Thyroid Cancer: A Population-Based Study of 735 Patients

International Journal of Endocrinology, 2019
Background. Anaplastic thyroid cancer (ATC) responds poorly to conventional therapies and requires a multidisciplinary approach to manage. The aim of the current study is to explore whether aggressive treatment is beneficial, especially the appropriate ...
Nai-si Huang, Xiao Shi, Bo-wen Lei, Wen-jun Wei, Zhong-wu Lu, Peng-cheng Yu, Yu Wang, Qing-hai Ji, Yu-long Wang   +8 more
doaj   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Are the demographics for squamous cell cancer in the head and neck changing in the United Kingdom?

, 2007
Head and neck squamous cell carcinoma is well known to be more common in men than women. Smoking and alcohol are the key risk factors causing such malignancies and there are several publications which have suggested that the prevalence of these diseases ...
Sackert, AA, Howard, DJ, Lund, VJ, Hassan, MA   +3 more
core  

Targeted treatment of head and neck (Pre)cancer: Preclinical target identification and development of novel therapeutic applications

, 2021
Head and neck squamous cell carcinomas (HNSCC) develop in the mucosal lining of the upper-aerodigestive tract. In carcinogen-induced HNSCC, tumors emerge from premalignant mucosal changes characterized by tumor-associated genetic alterations, also coined
van Harten, Anne M., Anne M. van Harten, Brakenhoff, Ruud H., van Harten, Anne, Ruud H. Brakenhoff   +4 more
core   +1 more source

Identification and molecular typing of disulfidptosis-related biomarkers in anaplastic thyroid carcinoma

Cell Death Discovery
Increasing evidence suggests that disulfidptosis plays a crucial role in tumorigenesis and progression. This study aimed to identify biomarkers closely associated with disulfidptosis in anaplastic thyroid carcinoma (ATC).
Weidong Teng, Yawen Guo, Lingling Ding, Aoni Zhou, Yehao Guo, Jiantong He, Lirong zhang, Haolan Yu, Zekai Tao, Jiafeng Wang, Jiajie Xu, Zhuo Tan, Liehao Jiang   +12 more
doaj   +1 more source