Results 81 to 90 of about 552,283 (212)

mTOR inhibitor use in head and neck squamous cell carcinoma: A meta‐analysis on survival, tumor response, and toxicity

Laryngoscope Investigative Otolaryngology, 2020
Background Head and neck squamous cell carcinoma (HNSCC) has been rising in incidence primarily related to HPV‐associated oropharyngeal cancers. Novel molecular therapeutics are evolving with the mTOR pathway as a new target.
Jaimin Patel, Shaun A. Nguyen, Besim Ogretmen, Jorge S. Gutkind, Cherie‐Ann Nathan, Terry Day   +5 more
doaj   +1 more source

Stage T4B head and neck cancer survival outcome comparisons based on treatment modality: is surgery a viable treatment option? [PDF]

, 2016
IMPORTANCE: Advanced stage head and neck cancers are often deemed unresectable due to the aggressive nature of the cancer. In evaluating survival patterns of patients with stage IVb tumors, it is valuable to determine whether patients who undergo ...
Kidwai, Neiha
core   +1 more source

Are the demographics for squamous cell cancer in the head and neck changing in the United Kingdom? [PDF]

, 2007
Head and neck squamous cell carcinoma is well known to be more common in men than women. Smoking and alcohol are the key risk factors causing such malignancies and there are several publications which have suggested that the prevalence of these diseases ...
Hassan, MA, Howard, DJ, Lund, VJ, Sackert, AA   +3 more
core  

Updated Clinical Considerations for Dental Implant Therapy in Irradiated Head and Neck Cancer Patients [PDF]

, 2013
An increasing number of reports indicate successful use of dental implants (DI) during oral rehabilitation for head and neck cancer patients undergoing tumor surgery and radiation therapy.
Chan, Hsun‐liang, MacEachern, Mark, Oh, Tae‐ju, Tanaka, Takako Imai, Tindle, David Ira   +4 more
core   +1 more source

Oncologic outcome of marginal mandibulectomy in squamous cell carcinoma of the lower gingiva

BMC Cancer, 2019
Background There is a large amount of controversy about the best management of the mandible in oral squamous cell carcinoma (SCC), mainly owing to the inability to acquire accurate bone invasion status.
Wei Du, Qigen Fang, Yao Wu, Junfu Wu, Xu Zhang   +4 more
doaj   +1 more source

Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource:head and neck 5000 [PDF]

, 2014
BACKGROUND: Head and neck cancer is an important cause of ill health. Survival appears to be improving but the reasons for this are unclear. They could include evolving aetiology, modifications in care, improvements in treatment or changes in lifestyle ...
Abdelkader, Maged, Ahmed, Imtiaz, Allmark, Christine, Anari, Shahram, Andrade, Gerard, Baldwin, Andrew, Balfour, Alistair, Barnes, Debi, Beaumont-Jewell, Dawn, Benson, Richard, Berry, Sandeep, Bisase, Brian, Brammer, Caroline, Carr, Ruth, Casasola, Richard, Christian, Judith, Coatesworth, Andrew, Cogill, Geoffrey, Cole, Naomi, Conway, David, Dallas, Nicola, Davies, Joe, Doyle, Margret, Dyker, Karen, Dyson, P, England, James, Evans, Andrew, Evans, Mererid, Fisher, Sheila, Foran, Bernie, Forster, Martin, Fresco, Lydia, Gahir, Daljit, Gollins, Simon, Goodchild, Kate, Gunasekaran, Sinnappa P, Hall, Charles, Hamid, Abdel, Hari, Churunal, Hollingworth, Will, Homer, Jarrod, Hurley, Katrina, Hwang, David, Hyde, Nicholas, Jankowska, Petra, Jeffreys, Mona, Kim, Dae, King, Emma, Lamont, Alan, Leary, Sam, Lees, Laura, Lester, Jim, Lester, Shane, Loo, H W, Lowe, Rachel, Mano, Joseph, McAllister, Ken, McCaul, James, Mehanna, Hisham, Moss, Laura, Moule, Russell, Ness, Andrew Robert, Nutting, Chris, Nutting, Christopher, O'Hara, James, Palaniappan, Nachi, Paleri, Vinidh, Penfold, Chris, Persson, Martin, Peters, Tim J, Pring, Miranda, Repanos, Costas, Richards, Stuart, Ring, Susan, Rogers, Simon, Roques, Tom, Rowell, Nick, Roy, Amy, Scrase, Christopher, Sen, Mehmet, Sheehan, Tom, Simcock, Richard, Siva, Muthu, Stewart, Simon, Tatla, Taran, Thiruchelvam, J K, Thomas, Steve, Tierney, Paul, Toms, Stu, Tyler, Jayne, Wagstaff, Lynda, Waldron, John, Waylen, Andrea, Wight, Richard, Winter, Stuart, Wood, Christine, Wood, Katie, Worthington, Helen   +97 more
core   +5 more sources

5-Aza-2′-deoxycytidin (Decitabine) increases cancer-testis antigen expression in head and neck squamous cell carcinoma and modifies immune checkpoint expression, especially in CD39-positive CD8 and CD4 T cells

Neoplasia: An International Journal for Oncology Research
Failure of immunotherapy in head and neck squamous cell carcinoma (HNSCC) patients represents an unmet need to augment leverage of adaptive immunity. Immunogenic cancer-testis antigen (CTA) expression as well as lymphocyte differentiation and function ...
Adrian Fehn, Adrian von Witzleben, Ayla Grages, Tsima Abou Kors, Jasmin Ezić, Annika C. Betzler, Cornelia Brunner, Patrick J. Schuler, Marie-Nicole Theodoraki, Thomas K. Hoffmann, Simon Laban   +10 more
doaj   +1 more source

CBCT-to-CT synthesis with a single neural network for head-and-neck, lung and breast cancer adaptive radiotherapy

, 2019
Purpose: CBCT-based adaptive radiotherapy requires daily images for accurate dose calculations. This study investigates the feasibility of applying a single convolutional network to facilitate CBCT-to-CT synthesis for head-and-neck, lung, and breast ...
Berg, Cornelis AT van den, Houweling, Anette C, Kotte, Alexis NTJ, Maspero, Matteo, Savenije, Mark HF, van Heijst, Tristan CF, Verhoeff, Joost JC   +6 more
core   +1 more source

Medial sural artery perforator free flap for small- to medium-sized defects in head and neck reconstruction: a suitable replacement for radial forearm free flap

Maxillofacial Plastic and Reconstructive Surgery
Background and objectives To compare clinical outcomes and donor site morbidity between medial sural artery perforator (MSAP) flap and radial forearm free (RFF) flap for soft tissue reconstruction of head and neck.
Yulian Zhang, Keran Pan, Jian Wu, Xi Tang   +3 more
doaj   +1 more source

Anti-EGFR therapy: strategies in head and neck squamous cell carcinoma. [PDF]

, 2016
Epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor that activates downstream signaling pathways, including the Ras-MEK-Erk and PI3K-AKT pathways, leading to cell proliferation, resistance to apoptosis, angiogenesis and the ability to ...
Carvalho, Ana-Carolina de, Oliveira-Silva, Renato J., Reis, R. M., Viana, Luciano de Souza   +3 more
core   +1 more source