Results 131 to 140 of about 216,489 (301)

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

Pediatric Head and Neck Pathology

, 2016
This unique reference provides a comprehensive guide to pediatric head and neck pathology in patients up to the age of 21. Chapters take a clinicopathologic approach, offering insight into the pathobiology, diagnosis and treatment of both common and rare
Sherif Said, Said, Sherif, Robert E. Marx, Robert O. Greer, Marx, Robert E, Prok, Lori D, Greer, Robert O, Lori D. Prok   +7 more
core   +1 more source

Paediatric cancers of the head and neck: An umbrella review

Journal of Pediatric Surgery Open
Background: Paediatric head and neck cancer relates to malignancies of the sinuses, nasal cavity, oral cavity, pharynx or larynx in children. The objective of this umbrella review was to collate the existing literature regarding prevalence, diagnosis and
John Beji Daniel, Emilija Jensen, Brianna Poirier, Richard Logan, Shridhar Krishnan, Sneha Sethi   +5 more
doaj   +1 more source

Clinical Practice Guideline: Evaluation of the Neck Mass in Adults

, 2017
Objective Neck masses are common in adults, but often the underlying etiology is not easily identifiable. While infections cause most of the neck masses in children, most persistent neck masses in adults are neoplasms.
Sandra A. Finestone, Pynnonen, Melissa A, Finestone, Sandra A, M. Boyd Gillespie, Richard M. Rosenfeld, Itzhak Brook, Roman, Benjamin, Corrigan, Maureen D, Benjamin Roman, Stern, Wendy B, Youngerman, Jay S, Chick, Davoren Ann, Griffith, Christopher C, Tunkel, David E, Melissa A. Pynnonen, Christopher C. Griffith, Levine, Corinna, Jason C. Fowler, Jay S. Youngerman, Mehta, Vikas, Salama, Andrew, Scharpf, Joseph, Laura Bontempo, Gillespie, M Boyd, Zeb Henson, Deborah R. Shatzkes, Andrew Salama, Rosenfeld, Richard M, Joseph Scharpf, Davoren Ann Chick, Maria Colandrea, Corinna Levine, Bontempo, Laura, David E. Tunkel, Fowler, Jason C, Vikas Mehta, Shatzkes, Deborah R, Brook, Itzhak, Colandrea, Maria, Wendy B. Stern, Maureen D. Corrigan, Henson, Zeb   +41 more
core   +1 more source

Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation

Advanced Science, EarlyView.
Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu, Jialu Kang, Qi Ye, Zixi Wang, Lei Li, Yuzeshi Lei, Leihong Ye, Tianjie Liu, Bin Wang, Tao Liu, Shan Xu, Ke Wang, Yong Zhang, Jian Ma, Lei Li   +14 more
wiley   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Avaliação do tratamento cirúrgico do carcinoma de osso temporal. [PDF]

, 2008
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina.
Pacheco, Maria Rosa Barbosa
core  

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Advanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang   +16 more
wiley   +1 more source

Expresión de mucinas y moléculas relacionadas en los carcinomas mucoepidermoides de glándulas salivales: implicaciones diagnósticas y pronósticas [PDF]

, 2011
[spa] El carcinoma mucoepidermoide, es el tumor maligno más frecuente de glándulas salivales (GS). Tanto su expresión de mucinas, MUC1 y MUC4, como el número de copias del gen EGFR (receptor del Factor de Crecimiento Epidérmico) y la expresión de pERK1/2
Luján, Blanca Noemí
core   +1 more source

Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma

Advanced Science, EarlyView.
SOX2 upregulates KAT7 in glioma stem cells, where KAT7 deposits H3K14 acetylation at the RAC2 promoter to activate RAC2 transcription. RAC2‐GTP subsequently promotes PAK1/2/3 phosphorylation, increasing tricarboxylic acid cycle flux and mitochondrial respiration to support glioblastoma malignancy.
Jilong Liu, Yanfei Sun, Yuehua Zhu, Guangjing Mu, Jiazheng Wang, Liangliang Wang, Feihu Zhao, Zhimin Zhao, Jian Wang, Ying He, Zheng Jiang, Xingang Li, Mingzhi Han, Bin Huang   +13 more
wiley   +1 more source