Results 121 to 130 of about 218,677 (332)

GLS1 Orchestrates Exosome‐Mediated Tumor‐Endothelial Communication to Facilitate Angiogenesis

Advanced Science, EarlyView.
This study reveals a previously unappreciated, non‐metabolic function of GLS1 in the control of tumor angiogenesis via exosome‐mediated CAV1‐TNC signaling, indicating that therapeutic targeting of GLS1 may offer a dual benefit by simultaneously suppressing tumor metabolic activity and angiogenic processes in head and neck cancer. ABSTRACT Glutaminase 1
Jianqiang Yang, Zhenzhen Fu, Fanghui Chen, Soumya Vijaya Kumar, Fan Yang, Yaochao Zheng, Yunqi Li, Yao Yao, Nabil F. Saba, Yong Teng   +9 more
wiley   +1 more source

Head and neck neoplasms.

Canadian family physician Medecin de famille canadien, 2013
Tumours of the head and neck show a wide spectrum of natural behaviour ranging from the most benign to the extremely lethal. Investigative techniques are of limited usefulness. History and physical examination are the foundations for diagnosis, though ultimate proof rests on surgical biopsy. The author of this article discusses the more common head and
openaire   +1 more source

Avaliação do tratamento cirúrgico do carcinoma de osso temporal. [PDF]

, 2008
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina.
Pacheco, Maria Rosa Barbosa
core  

Clinical Practice Guideline: Evaluation of the Neck Mass in Adults

, 2017
Objective Neck masses are common in adults, but often the underlying etiology is not easily identifiable. While infections cause most of the neck masses in children, most persistent neck masses in adults are neoplasms.
Sandra A. Finestone, Pynnonen, Melissa A, Finestone, Sandra A, M. Boyd Gillespie, Richard M. Rosenfeld, Itzhak Brook, Roman, Benjamin, Corrigan, Maureen D, Benjamin Roman, Stern, Wendy B, Youngerman, Jay S, Chick, Davoren Ann, Griffith, Christopher C, Tunkel, David E, Melissa A. Pynnonen, Christopher C. Griffith, Levine, Corinna, Jason C. Fowler, Jay S. Youngerman, Mehta, Vikas, Salama, Andrew, Scharpf, Joseph, Laura Bontempo, Gillespie, M Boyd, Zeb Henson, Deborah R. Shatzkes, Andrew Salama, Rosenfeld, Richard M, Joseph Scharpf, Davoren Ann Chick, Maria Colandrea, Corinna Levine, Bontempo, Laura, David E. Tunkel, Fowler, Jason C, Vikas Mehta, Shatzkes, Deborah R, Brook, Itzhak, Colandrea, Maria, Wendy B. Stern, Maureen D. Corrigan, Henson, Zeb   +41 more
core   +1 more source

Rewiring NADH Metabolism Through NQO1‐Mediated Redox Cycling for Targeted Follicular Lymphoma Therapy

Advanced Science, EarlyView.
ABSTRACT Follicular lymphoma (FL) remains an incurable B‐cell malignancy with high relapse rates, and conventional therapies are often limited by significant toxicity, highlighting the need for novel treatments. We identified that FL exhibits markedly low expression of NAD(P)H: quinone oxidoreductase 1 (NQO1), a key enzyme required for activating ...
Jinxing Zhang, Ziqi Wang, Ye Weng, Yulin Fu, Yuelong Jiang, Beilin Zhuang, Wenzi Zeng, Xiangchun Zhang, Bing Xu, Jie Zha, Hongjun Zhuang   +10 more
wiley   +1 more source

Surgical errors and risks - the head and neck cancer patient

, 2013
Head and neck surgery is one of the basic principles of head and neck cancer therapy. Surgical errors and malpractice can have fatal consequences for the treated patients.
Harréus, U
core   +1 more source

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Fine‐needle aspiration cytology in head and neck diagnosis

Clinical Case Reports, 2019
Key Clinical Message The proper performing of the fine‐needle aspiration cytology of head and neck neoplasms leads to an accurate preoperative diagnosis by an inexpensive and relatively simple technique.
Angela Tempesta, Luisa Limongelli, Saverio Capodiferro, Eugenio Maiorano, Gianfranco Favia   +4 more
doaj   +1 more source

Pediatric Head and Neck Pathology

, 2016
This unique reference provides a comprehensive guide to pediatric head and neck pathology in patients up to the age of 21. Chapters take a clinicopathologic approach, offering insight into the pathobiology, diagnosis and treatment of both common and rare
Sherif Said, Said, Sherif, Robert E. Marx, Robert O. Greer, Marx, Robert E, Prok, Lori D, Greer, Robert O, Lori D. Prok   +7 more
core   +1 more source

Noninvasive Characterization of Tumor Heterogeneity in HNSCC: From Clinical Utility to Biological Correlates

Advanced Science, EarlyView.
This study establishes a CT‐based radiomics framework to quantify intratumoral heterogeneity (ITH) in HNSCC. Using unsupervised clustering, tumor ROIs and VOIs are analyzed to calculate 2D/3D ITH scores. The score shows strong predictive value for prognosis and immunotherapy response, and is associated with tumor metabolism and immune microenvironment,
Xinwei Chen, Rui Liu, Yuan Zhou, Yin Xiao, Chengmin Feng, Lin Chen, Yanshi Li, Mengna Wang, Zhaobo Cheng, Yuxi Luo, Long Liu, Lijing Niu, Yue Xiang, Juan Peng, Guohua Hu, Min Pan   +15 more
wiley   +1 more source