Results 121 to 130 of about 209,032 (303)

Molecular Pathology of Skin Neoplasms of the Head and Neck

open access: yesArchives of Pathology and Laboratory Medicine, 2014
Context.— Skin neoplasms include the most common malignancies affecting humans. Many show an ultraviolet (UV)–induced pathogenesis and often affect the head and neck region. Objective.— To review literature on cutaneous neoplasms that ...
Stefan, Kraft, Scott R, Granter
openaire   +2 more sources

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

open access: yesAdvanced Science, EarlyView.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei   +18 more
wiley   +1 more source

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

open access: yesAdvanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu   +10 more
wiley   +1 more source

Head and neck cancer mortality by gender, region and ethnicity: a population-based study in BrazilResearch in context

open access: yesThe Lancet Regional Health. Americas
Summary: Background: Brazil exhibits the highest mortality rates for oral cavity (OCC), oropharyngeal (OPC), and laryngeal (LC) cancers in South-America.
Matheus de Abreu   +2 more
doaj   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

open access: yesAdvanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu   +20 more
wiley   +1 more source

Updates on Immunohistochemical and Molecular Markers in Selected Head and Neck Diagnostic Problems [PDF]

open access: yes, 2017
Context.— The head and neck regions have complex anatomic structures. They are not exempted from the rare occurrences of highly unusual, diagnostically challenging malignant neoplasms and mimickers.
Qihui (Jim) Zhai   +2 more
core   +1 more source

Evaluation of prognostic factors of head and neck squamous cell carcinomas in Iranian patients: A narrative review [PDF]

open access: yesJournal of Oral Health and Oral Epidemiology
BackgroundHead and neck squamous cell carcinoma (HNSCC) represents the largest proportion of head and neck cancers (HNCs). Despite new treatment modalities, the 5-year survival rate has not improved much.
Mahdieh Rajabi-Moghaddam   +1 more
doaj  

Trend Analysis of Head and Neck Neoplasms between 2012-2018 in Patients Residing in Al-Madinah, Saudi Arabia: A Retrospective Study. [PDF]

open access: yesEur J Dent, 2021
Alsharif MT   +8 more
europepmc   +1 more source

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