Results 101 to 110 of about 209,032 (303)

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

Advanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao, Bin Gu, Hui Zhao, Kun Tan, Qin Zhao, Zhengjun Shang   +5 more
wiley   +1 more source

Current update on the diagnosis and management of head and neck hard tissue sarcomas [PDF]

, 2017
Head and neck hard tissue sarcomas form a rare group of mesenchymal-derived tumours that comprise less than 1% of all head and neck neoplasms. Hard tissue sarcomas account for 20% of head and neck sarcomas and they form a heterogeneous group with a ...
Felipe Paiva Fonseca, Peter A. Brennan, Ricardo S. Gomez, Ben Tudor-Green, Ricardo Santiago Gomez, Peter Brennan   +5 more
core   +1 more source

Head and Neck Lymphomas in HIV Patients: a Clinical Perspective

International Archives of Otorhinolaryngology, 2017
Introduction Because of the many HIV-related malignancies, the diagnosis and treatment of lymphoma in patients infected with human immunodeficiency virus are challenging.
Natsuki Oishi, José Vicente Bagán, Karla Javier, Enrique Zapater   +3 more
doaj   +1 more source

HLA‐DR+ Schwann Cells Generate the Protumor Cancer‐Neuron‐Immune Niche in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Hijacked and educated by HNSCC cells, HLA‐DR+ Schwann cells lost their normal neural‐related functions but acquired immunoregulatory phenotypes to promote CD4+ T cells transform into Tregs. HLA‐DR+ Schwann cells induced a macrophage subpopulation, Il1β.
Xiaoyan Meng, Zhonglong Liu, Shijian Zhang, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +7 more
wiley   +1 more source

Epidemiologic study of oral and paraoral malignancies in one cancer referral center in Isfahan in a 5-year period

مجله دانشکده دندانپزشکی اصفهان, 2013
Introduction: Prevalence of malignancies is different in different communities and different at different times and locations in a community. Epidemiological studies can help recognize high-risk groups. The aim of this study was to evaluate the frequency
Atousa Aminzadeh, Ahmad Motaghi, Ebrahim Mohammadi   +2 more
doaj  

Global research trends in immunotherapy for head and neck neoplasms: A scientometric study. [PDF]

Heliyon, 2023
Jiang Z, Wu C, Zhao Y, Zhan Q, Wang K, Li Y.   +5 more
europepmc   +1 more source

Stiffness‐Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG‐TNS4 Signaling

Advanced Science, EarlyView.
Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu, Jian Wan, Xue Zhang, Jiashuai Yan, Xi Chen, Xiaoqi Guan, Qianqian Ren, Tao Yang, Di Wu, Qingsong Guo, Yibing Guo, Yuhua Lu   +11 more
wiley   +1 more source

Head and Neck Paragangliomas; Genetics, Heredity and Clinical Characteristics [PDF]

, 2012
Paragangliomas are rare neoplasms that occur predominantly in the head and neck region. They originate from the neural crest derived cells within paraganglions, and are closely related to the pheochromocytomas of the adrenal medulla. In contrast to other
Hensen, E.F.
core   +1 more source

Anterior Cervical Cystic Lymphangioma in an Adult Patient

Acta Médica Portuguesa
N/a.
Bárbara Neto Castro, Daniel Martins , David Afonso João , Susana Graça, Manuel Oliveira   +4 more
doaj   +1 more source

Ossifying fibromyxoid tumor of the oral cavity: rare case report and long-term follow-up

Autopsy and Case Reports, 2021
Ossifying fibromyxoid tumor (OFMT) is a rare mesenchymal soft tissue benign neoplasm with an uncertain line of differentiation, which arises most frequently in extremities.
Maria Eduarda Pérez-de-Oliveira, Thayná Melo de Lima Morais, Márcio Ajudarte Lopes, Oslei Paes de Almeida, Willie F. P. van Heerden, Pablo Agustin Vargas   +5 more
doaj