Results 91 to 100 of about 218,677 (332)

Prótese fonatória: uma nova opção para reabilitação vocal de pacientes laringectomizados. [PDF]

, 2000
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Departamento de Clínica Cirúrgica, Curso de Medicina, Florianópolis ...
Gerente, Marcos Miroski
core  

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Anterior Cervical Cystic Lymphangioma in an Adult Patient

Acta Médica Portuguesa
N/a.
Bárbara Neto Castro, Daniel Martins , David Afonso João , Susana Graça, Manuel Oliveira   +4 more
doaj   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Epidemiologic study of oral and paraoral malignancies in one cancer referral center in Isfahan in a 5-year period

مجله دانشکده دندانپزشکی اصفهان, 2013
Introduction: Prevalence of malignancies is different in different communities and different at different times and locations in a community. Epidemiological studies can help recognize high-risk groups. The aim of this study was to evaluate the frequency
Atousa Aminzadeh, Ahmad Motaghi, Ebrahim Mohammadi   +2 more
doaj  

Five-Year Survival and Associated Factors in Patients with Head and Neck Cancer in the Brazilian Amazon

Revista Brasileira de Cancerologia
Introduction: Head and neck cancer accounts for approximately 660,000 new cases annually worldwide and is increasing due to the consequences of interactions among environmental, socioeconomic and genetic factors, making it a multifactorial dysfunction ...
Lorena Cristine Soares Epaminondas, Maikon da Silva e Silva, Myara Cristiny Monteiro Cardoso, Leonardo Breno do Nascimento de Aviz, Maria Conceição Nascimento Pinheiro, Vânia Cristina Campelo Barroso Carneiro, Laura Maria Tomazi Neves, Saul Rassy Carneiro   +7 more
doaj   +1 more source

Ossifying fibromyxoid tumor of the oral cavity: rare case report and long-term follow-up

Autopsy and Case Reports, 2021
Ossifying fibromyxoid tumor (OFMT) is a rare mesenchymal soft tissue benign neoplasm with an uncertain line of differentiation, which arises most frequently in extremities.
Maria Eduarda Pérez-de-Oliveira, Thayná Melo de Lima Morais, Márcio Ajudarte Lopes, Oslei Paes de Almeida, Willie F. P. van Heerden, Pablo Agustin Vargas   +5 more
doaj  

Global research trends in immunotherapy for head and neck neoplasms: A scientometric study. [PDF]

Heliyon, 2023
Jiang Z, Wu C, Zhao Y, Zhan Q, Wang K, Li Y.   +5 more
europepmc   +1 more source

Prognostic factors in carcinoma of the external auditory canal

, 1997
Background: Carcinomas of the external auditory canal are rare neoplasms (
L. P. Kowalski, Testa, Jose Ricardo Gurgel [UNIFESP], Kowalski, Luiz Paulo [UNIFESP], J. R. G. Testa, Fukuda, Yotaka [UNIFESP], Y. Fukuda   +5 more
core   +1 more source