Results 91 to 100 of about 229,667 (331)

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Head and Neck Lymphomas in HIV Patients: a Clinical Perspective

International Archives of Otorhinolaryngology, 2017
Introduction Because of the many HIV-related malignancies, the diagnosis and treatment of lymphoma in patients infected with human immunodeficiency virus are challenging.
Natsuki Oishi, José Vicente Bagán, Karla Javier, Enrique Zapater   +3 more
doaj   +1 more source

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Anterior Cervical Cystic Lymphangioma in an Adult Patient

Acta Médica Portuguesa
N/a.
Bárbara Neto Castro, Daniel Martins , David Afonso João , Susana Graça, Manuel Oliveira   +4 more
doaj   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

Epidemiologic study of oral and paraoral malignancies in one cancer referral center in Isfahan in a 5-year period

مجله دانشکده دندانپزشکی اصفهان, 2013
Introduction: Prevalence of malignancies is different in different communities and different at different times and locations in a community. Epidemiological studies can help recognize high-risk groups. The aim of this study was to evaluate the frequency
Atousa Aminzadeh, Ahmad Motaghi, Ebrahim Mohammadi   +2 more
doaj  

Five-Year Survival and Associated Factors in Patients with Head and Neck Cancer in the Brazilian Amazon

Revista Brasileira de Cancerologia
Introduction: Head and neck cancer accounts for approximately 660,000 new cases annually worldwide and is increasing due to the consequences of interactions among environmental, socioeconomic and genetic factors, making it a multifactorial dysfunction ...
Lorena Cristine Soares Epaminondas, Maikon da Silva e Silva, Myara Cristiny Monteiro Cardoso, Leonardo Breno do Nascimento de Aviz, Maria Conceição Nascimento Pinheiro, Vânia Cristina Campelo Barroso Carneiro, Laura Maria Tomazi Neves, Saul Rassy Carneiro   +7 more
doaj   +1 more source

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Overview of the 2022 WHO Classification of Head and Neck Neuroendocrine Neoplasms

Head and Neck Pathology, 2022
Ö. Mete, B. Wenig
semanticscholar   +1 more source

Acetylsalicylic acid suppression of the PI3K pathway as a novel medical therapy for head and neck lymphatic malformations

, 2021
OBJECTIVES: Head and neck lymphatic malformations (HNLM) are caused by gain-of-function somatic mutations in PIK3CA. Acetylsalicylic acid (ASA/aspirin) is thought to limit growth in PIK3CA-mutated neoplasms through PI3K pathway suppression.
Zenner, Kaitlyn, Ganti, Sheila, Mitchell, Ryan M., Dobyns, William, Bly, Randall A., Whitlock, Kathryn B., Pham, Minh-Hang M., Bennett, James T., Dahl, John P., Jensen, Dana M., Cheng, Chi Vicky, Perkins, Jonathan A., Bonilla-Velez, Juliana, Kathryn B. Whitlock, Kaitlyn Zenner, James T. Bennett, Chi Vicky Cheng, John P. Dahl, Ryan M. Mitchell, Jonathan A. Perkins, Juliana Bonilla-Velez, Sheila Ganti, Dana M. Jensen, Minh-Hang M. Pham, Randall A. Bly, William Dobyns   +25 more
core   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source