Results 91 to 100 of about 216,489 (301)

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, EarlyView.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source

Rapid In Vitro Pathological Diagnosis of Glioma Using Dual‐Color Quantum Dot Probes for Precise Intraoperative Resection

Advanced Science, EarlyView.
Glioma resection surgery is challenging because of the infiltrative growth of the tumor into nearby tissue and the different surgical requirements for gliomas with different mutation types. To improve the precision and effectiveness of glioma resection, this study developed a new imaging probe that enables the tumor boundary and mutation status to be ...
Dongdong Wu, Chenxuan Yang, Yuanbin Wu, Minghang Liu, Yizhi Zhang, Yuang Cai, Yibo Zhang, Jimei Chi, Hengchao Ma, Ding Zhang, Chenqing Liu, Meng Su, Guochen Sun   +12 more
wiley   +1 more source

Tobacco and Alcohol Use and Clinical Staging of Head and Neck Tumors

Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 2022
Objective: To determine the relationship between tobacco and alcohol consumption and staging of head and neck cancer in patients treated at a referral hospital for cancer treatment.
Cátia Maria Guanaes Silva, Danilo Barral de Araújo, Gabriela Botelho Martins, Elisângela de Jesus Campos, Roberto Paulo Correia de Araújo   +4 more
doaj  

PDGFRα+/Integrin α2+ Fibroblasts Orchestrate Tumor Budding in Oral Squamous Cell Carcinoma via Mechano‐Metabolic Symbiosis: E‐Cadherin/Integrin α2β1 Adhesion and Mitochondrial Transfer

Advanced Science, EarlyView.
PDGFA/PDGFRα signaling recruits CAFs to OSCC nests, and CAF‐OSCC contact drives tumor budding invasion. Mechanistically, heterotypic adhesion via E‐cadherin/integrin α2β1 activates YAP signaling in OSCC cells, inducing EMT. Concurrently, CAFs transfer mitochondria through TNTs, supplying ATP to fuel invasion.
Yufang Liu, Jiao Li, Juan Liu, Qi Dong, Haoyang Zhang, Yanjin Wang, Huibing Li, Ye Guan, Lei Cao, Manqing Zhang, Fangning Guo, Xue Liu, Zhen Yang, Mengmeng Lu, Hui Liu, Laiping Zhong, Tong Ji, Tingjiao Liu   +17 more
wiley   +1 more source

Head and Neck Lymphomas in HIV Patients: a Clinical Perspective

International Archives of Otorhinolaryngology, 2017
Introduction Because of the many HIV-related malignancies, the diagnosis and treatment of lymphoma in patients infected with human immunodeficiency virus are challenging.
Natsuki Oishi, José Vicente Bagán, Karla Javier, Enrique Zapater   +3 more
doaj   +1 more source

EpCAM+ Extracellular Vesicle PD‐L1 Dynamics as a Predictive Biomarker of Immune Checkpoint Blockade Response

Advanced Science, EarlyView.
A highly sensitive SERS‐based platform measures PD‐L1 expression on EpCAM+ circulating EVs from cancer patients undergoing immunotherapy. Monitoring dynamic changes after treatment reveals that reduced EpCAM+ EV PD‐L1 levels associate with improved long‐term clinical outcomes, establishing a non‐invasive approach for tracking immune checkpoint ...
Byeonggeol Mun, Jinyoung Kim, Chang Gon Kim, Seokhyeong Go, Mina Han, Yujin Ouck, Soojin Jang, Seong Uk Son, Gamin Kim, Wonrak Son, Eunjung Kim, Min Hee Hong, Ja Hyun Yeo, Eun‐Kyung Lim, Hye Ryun Kim, Seungjoo Haam   +15 more
wiley   +1 more source

Epidemiologic study of oral and paraoral malignancies in one cancer referral center in Isfahan in a 5-year period

مجله دانشکده دندانپزشکی اصفهان, 2013
Introduction: Prevalence of malignancies is different in different communities and different at different times and locations in a community. Epidemiological studies can help recognize high-risk groups. The aim of this study was to evaluate the frequency
Atousa Aminzadeh, Ahmad Motaghi, Ebrahim Mohammadi   +2 more
doaj  

Anterior Cervical Cystic Lymphangioma in an Adult Patient

Acta Médica Portuguesa
N/a.
Bárbara Neto Castro, Daniel Martins , David Afonso João , Susana Graça, Manuel Oliveira   +4 more
doaj   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Five-Year Survival and Associated Factors in Patients with Head and Neck Cancer in the Brazilian Amazon

Revista Brasileira de Cancerologia
Introduction: Head and neck cancer accounts for approximately 660,000 new cases annually worldwide and is increasing due to the consequences of interactions among environmental, socioeconomic and genetic factors, making it a multifactorial dysfunction ...
Lorena Cristine Soares Epaminondas, Maikon da Silva e Silva, Myara Cristiny Monteiro Cardoso, Leonardo Breno do Nascimento de Aviz, Maria Conceição Nascimento Pinheiro, Vânia Cristina Campelo Barroso Carneiro, Laura Maria Tomazi Neves, Saul Rassy Carneiro   +7 more
doaj   +1 more source