Results 71 to 80 of about 218,677 (332)

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Knowledge about head and neck cancer among adolescents

Brazilian Journal of Otorhinolaryngology
Objective: To assess knowledge about head and neck cancer among adolescents from private schools, aged between 13 and22 years. Methods: 200 questionnaires were applied among students, about the profile of adolescents and their knowledge about head and ...
Vinicius M. Vasconcellos, Leandro Luongo Matos, Flavio Carneiro Hojaij, Edevaldo Miguel Alves, Beatriz Costa N. Martins, Arthur C. Nava   +5 more
doaj   +1 more source

Clinico-histocytopathological profile of paediatric head and neck malignant neoplasms: a mini-review

, 2018
Head and neck malignant neoplasms are reported to be the tenth most common cancer globally. They are associated with potential morbidity and mortality because of their tendency to interfere with vital functions of life such as breathing, swallowing ...
Kahinga, A.A., Swai, H, Abraham, Z.S., Massawe, E.R.   +3 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Silent intruders: Hematolymphoid neoplasms revealed in the jaws: a series of three cases

Indian Journal of Pathology and Microbiology
The head and neck regions, rich in lymph nodes, are common initial sites for nodal and extranodal hematolymphoid neoplasms, particularly B-cell neoplasms. Lymphomas, including Hodgkin’s and non-Hodgkin’s types, range from indolent to aggressive and often
Trupti Jain, Sudeep Kumar, Shivangni Rajoria, R Keerthika, Akhilesh Chandra, Rahul Agarwal   +5 more
doaj   +1 more source

Neuroendocrine neoplasms of the larynx: An overview [PDF]

, 2009
Neuroendocrine neoplasms of the larynx are rare but are the most common nonsquamous tumors of this organ. In the past, there has been considerable confusion about the nature and classification of these neoplasms, but the current consensus is that there ...
Rinaldo, Alessandra, Alfio Ferlito, Carol R. Bradford, Ferlito, Alfio, Bradford, Carol R., Silver, Carl E., Alessandra Rinaldo, Carl E. Silver   +7 more
core   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

[Diagnostic and predictive molecular pathology of head and neck neoplasms].

, 2018
As a result of some seminal observations as well as a consequence of increasing use of modern and innovative molecular diagnostic technologies, a variety of new genetic aberrations have been discovered in head and neck neoplasms of different anatomic ...
Agaimy, A;Weichert, W;Haller, F;Hartmann, A
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Quality of life of patients treated surgically for head and neck cancer

, 1992
The quality of survival of 48 patients treated surgically for head and neck cancer was assessed using a problem-orientated self-administered questionnaire. The questionnaire was based on the European Organization for Research into the Treatment of Cancer
Howard, DJ, McCarthy, M, Jones, E, Lund, VJ, Greenberg, MP   +4 more
core