Results 61 to 70 of about 218,677 (332)

Scoping review of head and neck neoplasms presenting with obstructive sleep apnoea: the importance of flexible nasendoscopy [PDF]

, 2020
Background Obstructive sleep apnoea (OSA) can be caused by neoplasms involving the upper aerodigestive tract. Currently, many of these patients have this diagnosis missed, as most adults diagnosed with OSA do not undergo adequate head and neck ...
Flatman, Samuel, Felipe Cardemil, Hayward, Nathan J., Cardemil Morales, Felipe, Nathan J. Hayward, Moore, Phillip, Phillip Moore, Samuel Flatman   +7 more
core   +1 more source

GPR124 Alleviates Blood–Brain Barrier Disruption by Enhancing Microvascular Endothelial Function after Traumatic Brain Injury

Advanced Science, EarlyView.
Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang, Lin Cai, Qiuyuan Gong, Yang Yang, Yuqing Liang, Xinyu Niu, Lai Wei, Ze Liu, Shengju Wu, Yinghui Men, Yaohui Tang, Jun Ding, Hengli Tian, Hao Chen   +13 more
wiley   +1 more source

Chromosome 22q a frequent site of allele loss in head and neck carcinoma

, 2000
Background. Loss of heterozygosity (LOH) correlates with inactivated tumor suppressor genes. LOH at chromosome arm 22q has been found in a variety of human neoplasms, suggesting that this region contains a tumor suppressor gene(s) other than NF2 ...
Kowalski, Luiz P., Rogatto, Silvia Regina [UNESP], Bergamo, N. A., Reis, Patricia P. [UNESP], Rogatto, Silvia R. [UNESP], Zielenska, M., Squire, Jeremy A., Poli-Frederico, R. C., Bergamo, Nadia A. [UNESP], Reis, P. P., Zielenska, Maria, Poli-Frederico, Regina C. [UNESP], Kowalski, L. P., Squire, J. A., Rogatto, Silvia Regina   +14 more
core   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Development and Validation of a Pathomics Model Using Machine Learning to Predict Expression and Prognosis in Head and Neck Cancer [PDF]

Clinical and Experimental Otorhinolaryngology
Objectives. The necessity to develop a method for prognostication and to identify novel biomarkers for personalized medicine in patients with head and neck squamous cell carcinoma (HNSCC) cannot be overstated.
Weihua Wang, Suyu Ruan, Yuhang Xie, Shengjian Fang, Junxian Yang, Xueyan Li, Yu Zhang   +6 more
doaj   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Surgical Management of a Multicentric Head-and-Neck Glomus Tumor: A Rare Case of Right Glomus Jugulare with Bilateral Carotid Body Tumors

Indian Journal of Vascular and Endovascular Surgery
Glomus tumors, also known as paragangliomas or chemodectomas, are usually slow–growing, benign, highly vascular tumors of neuroendocrine origin. Glomus tumors (paragangliomas) represent 0.6% of neoplasms of the head and neck and 0.03% of all neoplasms ...
Devender Singh, Manusrut Manusrut, Praveena Madavan, Shalini Aryala   +3 more
doaj   +1 more source

Use of free microvascular flaps in the management of the head and neck defects [PDF]

Vojnosanitetski Pregled, 2006
Background/aim: In the field of contemporary head and neck reconstructive surgery, free vascularized tissue transfer is becoming a gold standard. The aim of this study was to review our clinical results and experience, with use of free microvascular ...
Nikolić Živorad, Jeremić Jelena, Milosavljević Radoje   +2 more
doaj   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Nuchal Fibroma: An Uncommon Neck Mass

Bengal Journal of Otolaryngology and Head Neck Surgery, 2018
Introduction Nuchal fibroma or collagenosis nuchae is a rare benign tumour. It is a slow growing neoplasia of unknown etiogenesis, asymptomatic and of variegated histology. They are more common in males but our case was a female patient.
Soumyajit Das, Subhasish Mukherjee, Barun Sharma, Subash Tamang   +3 more
doaj