Results 41 to 50 of about 216,489 (301)

Evaluation of Routine Ear, Nose, and Throat Screening in Heart Transplant Candidates: A Retrospective Cohort Study [PDF]

, 2023
Background: Patients with end-stage heart failure refractory to medication can be treated with a heart transplant (HTx). These patients are subjected to a preoperative screening procedure according to International Society for Heart and Lung ...
Roest, Stefan, Nagtegaal, Andries P., Datema, Frank R., Vroonhof, Lidewij L., Manintveld, Olivier C.   +4 more
core   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Clinico-histocytopathological profile of paediatric head and neck malignant neoplasms: a mini-review [PDF]

, 2018
Head and neck malignant neoplasms are reported to be the tenth most common cancer globally. They are associated with potential morbidity and mortality because of their tendency to interfere with vital functions of life such as breathing, swallowing ...
Kahinga, A.A., Swai, H, Abraham, Z.S., Massawe, E.R.   +3 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

SMARCB1 (INI‐1) and NUT immunoexpression in a large series of head and neck carcinomas in a Brazilian reference center

, 2020
Background: SMARCB1 (INI-1)-deficient carcinomas and NUT carcinomas are aggressive neoplasms, often affecting the sinonasal region. Not uncommonly, their diagnoses are made retrospectively. Methods: Through SMARCB1 (INI-1) and NUT immunomarkers, 643 head
Almeida, Luciana Y. [UNESP], Evânio V. Silva, Silva, Evânio V. [UNESP], Alfredo Ribeiro‐Silva, Luciana Y. Almeida, Tulio M. Ferrisse, Vanzolin, Bárbara F., Heitor A. Silveira, León, Jorge E., Neves-Silva, Rodrigo, Jorge E. León, Silveira, Heitor A. [UNESP], Colturato, Carla B. N., Andressa Duarte, Ribeiro-Silva, Alfredo, Rodrigo Neves‐Silva, Andreia Bufalino, Duarte, Andressa, Ferrisse, Tulio M. [UNESP], Carla B. N. Colturato, Bárbara F. Vanzolin, Bufalino, Andreia [UNESP]   +21 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Quality of life of patients treated surgically for head and neck cancer [PDF]

, 1992
The quality of survival of 48 patients treated surgically for head and neck cancer was assessed using a problem-orientated self-administered questionnaire. The questionnaire was based on the European Organization for Research into the Treatment of Cancer
Howard, DJ, McCarthy, M, Jones, E, Lund, VJ, Greenberg, MP   +4 more
core  

[Grading of head and neck neoplasms].

, 2016
Tumors of the head and neck form a heterogeneous group of benign and malignant neoplasms with significant differences in biological behavior and therapeutic strategies.
Agaimy, A;Weichert, W
core   +1 more source

Radioimmunodetection and radioimmunotherapy of head and neck cancer. [PDF]

, 2004
Radiolabeled monoclonal antibodies (MAbs) can add a dimension to diagnostic imaging and staging of metastatic head and neck cancer, as well as in eradication of this disease.
Börjesson, Pontus K.E., Kairemo, K.J., Van Dongen, Guus A.M.S., Borjesson, P.K.E., Leemans, C. René, Postema, EJ, Bree, R. de, Kairemo, KJ, Postema, E.J., Postema, Ernst J., Leemans, C.R., Dongen, G.A.M.S. van, Borjesson, P.K., De Bree, Remco, Roos, Jan C., Kairemo, Kalevi J.A., Roos, J.C.   +16 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source