Results 51 to 60 of about 229,667 (331)

Lateral Arm Microvascular Flap in Head and Neck Reconstruction

, 1997
OBJECTIVES: To report our results of a study of 28 patients who underwent sequential reconstructions of the head and neck using the lateral arm flap. To discuss the situations where we have found the procedure useful, report the complication rates, and ...
Lu, Fang-Ling, Burkey, Brian, Armstrong, William, Civantos, Francisco J   +3 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Dermoscopic and clinical features of head and neck melanoma [PDF]

Anais Brasileiros de Dermatologia, 2015
BACKGROUND:The dermoscopic criteria of extrafacial melanomas are well-known.OBJECTIVE:To determine the frequency of dermatoscopic findings in head and neck melanomas (HNM) and to assess the distinguishing dermoscopic criteria of facial and extrafacial ...
Fatma Pelin Cengiz, Abdurrahman Bugra Cengiz, Nazan Emiroglu, Ela Comert, Rainer Hofmann Wellenhof   +4 more
doaj   +1 more source

Artificial Intelligence in Head and Neck Cancer: Towards Precision Medicine [PDF]

Head and neck cancer (HNC) encompasses malignant neoplasms originating from the soft tissues of the nasal cavity, paranasal sinuses, oral cavity, pharynx, larynx, skin, and thyroid [...
Adam Bess, Hornung, Logan, Sagar Kansara, Contrera, Kevin, Guillaume Spielmann, Bess, Ada, Logan Hornung, Barham, William, Mukhopadhyay, Supratik, Hagen, Jacob, Devraj Basu, Kevin Contrera, William Barham, Spielmann, Guillaume, Sandulache, Vlad, Supratik Mukhopadhyay, Vlad Sandulache, Jacob Hagen, Kansara, Sagar, Bess, Adam, Basu, Devraj   +20 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Updates on Immunohistochemical and Molecular Markers in Selected Head and Neck Diagnostic Problems

, 2017
Context.— The head and neck regions have complex anatomic structures. They are not exempted from the rare occurrences of highly unusual, diagnostically challenging malignant neoplasms and mimickers.
Qihui (Jim) Zhai, Chun-Hui Yi, Beverly Y. Wang   +2 more
core   +1 more source

Histopathology of head and neck

, 2020
Biopsies from ‘head and neck’ region which include ‘oral cavity’ and ‘oropharynx’ with a plethora of ‘proliferative squamous lesions’, sinonasal and nasopharyngeal lesions and above all a larger variety of ‘odontogenic cysts’ and ‘odontogenic neoplasms ...
Arshad, Sidra, Pervez, Shahid, Ud Din, Nasir, Sidra Arshad, Shahid Pervez, Nasir Ud Din   +5 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Prognostic factors in carcinoma of the external auditory canal

, 1997
Background: Carcinomas of the external auditory canal are rare neoplasms (
L. P. Kowalski, Testa, Jose Ricardo Gurgel [UNIFESP], Kowalski, Luiz Paulo [UNIFESP], J. R. G. Testa, Fukuda, Yotaka [UNIFESP], Y. Fukuda   +5 more
core   +1 more source