Results 81 to 90 of about 209,032 (303)

Nuchal Fibroma: An Uncommon Neck Mass

Bengal Journal of Otolaryngology and Head Neck Surgery, 2018
Introduction Nuchal fibroma or collagenosis nuchae is a rare benign tumour. It is a slow growing neoplasia of unknown etiogenesis, asymptomatic and of variegated histology. They are more common in males but our case was a female patient.
Soumyajit Das, Subhasish Mukherjee, Barun Sharma, Subash Tamang   +3 more
doaj  

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Knowledge about head and neck cancer among adolescents

Brazilian Journal of Otorhinolaryngology
Objective: To assess knowledge about head and neck cancer among adolescents from private schools, aged between 13 and22 years. Methods: 200 questionnaires were applied among students, about the profile of adolescents and their knowledge about head and ...
Vinicius M. Vasconcellos, Leandro Luongo Matos, Flavio Carneiro Hojaij, Edevaldo Miguel Alves, Beatriz Costa N. Martins, Arthur C. Nava   +5 more
doaj   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Silent intruders: Hematolymphoid neoplasms revealed in the jaws: a series of three cases

Indian Journal of Pathology and Microbiology
The head and neck regions, rich in lymph nodes, are common initial sites for nodal and extranodal hematolymphoid neoplasms, particularly B-cell neoplasms. Lymphomas, including Hodgkin’s and non-Hodgkin’s types, range from indolent to aggressive and often
Trupti Jain, Sudeep Kumar, Shivangni Rajoria, R Keerthika, Akhilesh Chandra, Rahul Agarwal   +5 more
doaj   +1 more source

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Neuroendocrine neoplasms of the larynx: An overview [PDF]

, 2009
Neuroendocrine neoplasms of the larynx are rare but are the most common nonsquamous tumors of this organ. In the past, there has been considerable confusion about the nature and classification of these neoplasms, but the current consensus is that there ...
Rinaldo, Alessandra, Alfio Ferlito, Carol R. Bradford, Ferlito, Alfio, Bradford, Carol R., Silver, Carl E., Alessandra Rinaldo, Carl E. Silver   +7 more
core   +1 more source

Noninvasive Characterization of Tumor Heterogeneity in HNSCC: From Clinical Utility to Biological Correlates

Advanced Science, EarlyView.
This study establishes a CT‐based radiomics framework to quantify intratumoral heterogeneity (ITH) in HNSCC. Using unsupervised clustering, tumor ROIs and VOIs are analyzed to calculate 2D/3D ITH scores. The score shows strong predictive value for prognosis and immunotherapy response, and is associated with tumor metabolism and immune microenvironment,
Xinwei Chen, Rui Liu, Yuan Zhou, Yin Xiao, Chengmin Feng, Lin Chen, Yanshi Li, Mengna Wang, Zhaobo Cheng, Yuxi Luo, Long Liu, Lijing Niu, Yue Xiang, Juan Peng, Guohua Hu, Min Pan   +15 more
wiley   +1 more source

Clinical Practice Guideline: Evaluation of the Neck Mass in Adults [PDF]

, 2017
Objective Neck masses are common in adults, but often the underlying etiology is not easily identifiable. While infections cause most of the neck masses in children, most persistent neck masses in adults are neoplasms.
Sandra A. Finestone, Pynnonen, Melissa A, Finestone, Sandra A, M. Boyd Gillespie, Richard M. Rosenfeld, Itzhak Brook, Roman, Benjamin, Corrigan, Maureen D, Benjamin Roman, Stern, Wendy B, Youngerman, Jay S, Chick, Davoren Ann, Griffith, Christopher C, Tunkel, David E, Melissa A. Pynnonen, Christopher C. Griffith, Levine, Corinna, Jason C. Fowler, Jay S. Youngerman, Mehta, Vikas, Salama, Andrew, Scharpf, Joseph, Laura Bontempo, Gillespie, M Boyd, Zeb Henson, Deborah R. Shatzkes, Andrew Salama, Rosenfeld, Richard M, Joseph Scharpf, Davoren Ann Chick, Maria Colandrea, Corinna Levine, Bontempo, Laura, David E. Tunkel, Fowler, Jason C, Vikas Mehta, Shatzkes, Deborah R, Brook, Itzhak, Colandrea, Maria, Wendy B. Stern, Maureen D. Corrigan, Henson, Zeb   +41 more
core   +1 more source

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source