Results 81 to 90 of about 216,489 (301)

CD177 Deficiency Defines a Stable Subtype of Human Neutrophil Granulocytes with Tumor Promoting Activity

Advanced Science, EarlyView.
Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung, Alexander Beer, Susmita Ghosh, Ekaterina Pylaeva, Belal Alshaar, Tobias Tertel, Nils Bastian Leimkühler, Thomas Schroeder, Janine Gronewold, Nina Hagemann, Ayan Mohamud Yusuf, Benedikt Frank, Yiqiao Zhang, Dennis Nagel, Kim Schloeßer, Laura Karsch, Emily Hedtfeld, Sabrina Lohmann, Kathrin Blank, Andreas Kraus, Max Krumbein, Nastassia Kabankova, Hongxiao Wang, Almke Bader, Mathis Richter, Fengjun Zhang, Raphael Chevre, Bernd Giebel, Stephan Lang, Anika Grüneboom, Daniela Maier‐Begandt, Anja Hasenberg, Oliver Soehnlein, Hans Christian Reinhardt, Sven Heiles, Jianxu Chen, Jadwiga Jablonska, Albert Sickmann, Dirk M. Hermann, Matthias Gunzer   +39 more
wiley   +1 more source

[Diagnostic and predictive molecular pathology of head and neck neoplasms].

, 2018
As a result of some seminal observations as well as a consequence of increasing use of modern and innovative molecular diagnostic technologies, a variety of new genetic aberrations have been discovered in head and neck neoplasms of different anatomic ...
Agaimy, A;Weichert, W;Haller, F;Hartmann, A
core   +1 more source

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, EarlyView.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Head and Neck Paragangliomas; Genetics, Heredity and Clinical Characteristics [PDF]

, 2012
Paragangliomas are rare neoplasms that occur predominantly in the head and neck region. They originate from the neural crest derived cells within paraganglions, and are closely related to the pheochromocytomas of the adrenal medulla. In contrast to other
Hensen, E.F.
core  

Head and neck pathology

, 2017
This chapter discusses head and neck pathology and covers benign oral cavity diseases, oral/oropharyngeal carcinoma, benign sinonasal diseases, sinonasal malignancies, nasopharyngeal diseases, benign laryngeal diseases, laryngeal carcinoma, odontogenic ...
James Carton
core   +1 more source

Hürthle cell neoplasms of the thyroid: Pathologic outcomes and ultrasonographic analysis

, 2020
Background: Fine-needle aspiration (FNA) of thyroid nodules suspicious for Hürthle cell neoplasms (HCN) have uncertain rate of malignancy. We aim to characterize rate and predictors of malignancy at our institution and compare these findings with ...
Henna D. Murthy, Michael W. Sim, Murthy, Henna D., Cyrus C. Rabbani, Sim, Michael W., Rabbani, Cyrus C., Timothy J. Shin, Shin, Timothy J., Katie Traylor, Traylor, Katie   +9 more
core   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source

Lipoblastomatosis of the retropharyngeal space: pathogenesis, presentation, and management, with a focus on head-neck lipoblastoma(toses)

B-ENT, 2016
Lipoblastomatosis of the retropharyngeal space: pathogenesis, presentation, and management, with a focus on head-neck lipoblastoma(toses). Objective: Lipoblastoma(toses) are benign neoplasms of embryonic white fat in a state of arrested maturation, and ...
M. Dutta, S. Kundu, S. Roy, S. Mukhopadhyay   +3 more
doaj   +2 more sources

Primary childhood head and neck neoplasms: An 8 -year histopathological review in a teaching hospital

Sahel Medical Journal, 2010
Background: Although infectious diseases remain the leading cause of death among children in our environment, neoplastic diseases have emerged as important cause of childhood morbidity and mortality.
Alex P Igbe, WHson O Akhiwu
doaj