Results 91 to 100 of about 206,195 (300)

The prognostic role of VEGF in head and neck squamous cell carcinoma [PDF]

, 2017
Emerging from potentially malignant disorders that in most cases will never become cancerous, head and neck squamous cell carcinoma (HNSCC) is a cancer that is extremely difficult to diagnose early.
Mathew, Rohit Thomas
core  

The immunohistochemical expression of leptin in lymph node metastasis from laryngeal squamous cell carcinoma (SCC) [PDF]

, 2020
Introduction: Leptin is a proteohormone produced predominantly by white adipocytes and primarily known for its key role in the control of food intake and sense of satiety.
D'Alessi S, Ferrara S, Florena AM, Galletti B, Galletti F, Gargano R, Greco G, Verro .   +7 more
core   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Violacein, an indole-derived purple-colored natural pigment produced by Janthinobacterium lividum, inhibits the growth of head and neck carcinoma cell lines both in vitro and in vivo [PDF]

, 2015
Violacein (VIO; 3-[1,2-dihydro-5-(5-hydroxy-1H-indol-3-yl)-2-oxo-3H-pyrrol-3-ylidene]-1,3-dihydro-2H-indol-2-one), an indole-derived purple-colored pigment, produced by a limited number of Gram-negative bacteria species, including Chromobacterium ...
Bei, Roberto, Benvenuto, Monica, DI STEFANO, Enrica, Fantini, Massimo, LA REGINA, Giuseppe, Manzari, Vittorio, Masuelli, Laura, Mattei, Maurizio, Mattera, Rosanna, Modesti, Andrea, Pantanella, Fabrizio, Schippa, Serena, Silvestri, Romano   +12 more
core   +1 more source

Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion

Advanced Science, EarlyView.
FUT8‐mediated core fucosylation of CD47 at N111 blocks SMURF1 binding and reduces CD47 ubiquitination and degradation. Blocking N111 glycosylation reduces CD47 expression and promotes macrophage phagocytosis of tumor cells. Furthermore, ablating CD47 core fucosylation boosts CD103+ dendritic cells (DCs) infiltration, increases natural killer (NK) cell ...
Yuting Cao, Siyuan Chai, Mingyang Li, Xiaoming Chen, Jiating Hu, Bingyi Lin, Liming Wu, Wen Yi, Qiang Zhu   +8 more
wiley   +1 more source

Fluorodeoxyglucose positron emission tomography–computed tomography missed tibial metastasis in head and neck cancer: a case report and review of literature

Journal of Medical Case Reports
Introduction Head and neck squamous cell carcinoma is the seventh most common type of cancer in the world. Metastases occur in up to 40% of cases, and bones are the second most frequent site.
Hamidreza Movahedi, Lena Nazemi, Saina Ghadiany, Alireza Movahedi, Farzad Dehghani Mahmoudabadi, Mohammadhossein Aghazadeh, Seyed Esmaeil Mousavi, Shaghayegh Khodabakhshian   +7 more
doaj   +1 more source

Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression

Advanced Science, EarlyView.
This study demonstrates meningeal lymphatic impairment associated with lung adenocarcinoma brain metastasis progression in both human patients and mouse models, establishes clinically applicable non‐invasive imaging biomarkers for quantitative analyzing mLV structure and function, and reveals mLVs as robust prognostic indicators and promising potential
Yuan Zhang, Shucheng Jin, Penghui Guo, Yuying Yin, Yichun Hua, Xiaosheng Ding, Zhe Zhang, Shuo Chen, Xu Han, Baowang Li, Yan Liu, Xiaoyan Li, Deling Li, Jing Jing, Wei Shi, Wang Jia   +15 more
wiley   +1 more source

Are the demographics for squamous cell cancer in the head and neck changing in the United Kingdom? [PDF]

, 2007
Head and neck squamous cell carcinoma is well known to be more common in men than women. Smoking and alcohol are the key risk factors causing such malignancies and there are several publications which have suggested that the prevalence of these diseases ...
Hassan, MA, Howard, DJ, Lund, VJ, Sackert, AA   +3 more
core  

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source